Development of radiation dose reduction techniques for cadmium zinc telluride detectors in molecular breast imaging

O’Connor, Michael K.; Hruska, Carrie B.; Weinmann, Amanda; Manduca, Armando; Rhodes, Deborah J.

doi:10.1117/12.864649

Cited by 5 publications

(9 citation statements)

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“…At our institution, a recent work on dose reduction methods for MBI has indicated that the administered dose of Tc-99m sestamibi can be reduced to 148 MBq with no degradation in image quality and that it may be possible to achieve further reductions to 74 MBq. 26 At these dose levels, Table VII shows that in women with dense breast tissue, MBI can achieve an acceptable benefit/risk ratio to warrant further evaluation in this population. Dedicated molecular imaging technologies for the breast are still in their infancy and we believe that future refinements to these technologies will enable them to be performed with significantly lower doses than what have been used to date.…”

Section: Discussionmentioning

confidence: 98%

“…Likewise, in MBI, a recent work has shown a variety of improvements that permit the administered dose to be reduced to 150 MBq. 26 We believe that molecular imaging technologies will yield a significant improvement in sensitivity relative to mammography, and with enhancements to the technology, may play an important role as adjunct screening techniques in the future.…”

Section: Discussionmentioning

confidence: 99%

“…We have recently implemented a number of hardware and software enhancements to MBI technology, which has resulted in a reduction in the required dose of Tc-99m sestamibi to 296 MBq. 26 Initial results indicate that the required dose of Tc-99m sestamibi can be further reduced to 74-148 MBq ͑Ref. 26͒ and we have recently commenced clinical studies evaluating this low-dose strategy.…”

Section: ͑15͒mentioning

confidence: 99%

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Comparison of radiation exposure and associated radiation‐induced cancer risks from mammography and molecular imaging of the breasta)

O’Connor

Rhodes

et al. 2010

Medical Physics

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Purpose: Recent studies have raised concerns about exposure to low-dose ionizing radiation from medical imaging procedures. Little has been published regarding the relative exposure and risks associated with breast imaging techniques such as breast specific gamma imaging ͑BSGI͒, molecular breast imaging ͑MBI͒, or positron emission mammography ͑PEM͒. The purpose of this article was to estimate and compare the risks of radiation-induced cancer from mammography and techniques such as PEM, BSGI, and MBI in a screening environment. Methods: The authors used a common scheme for all estimates of cancer incidence and mortality based on the excess absolute risk model from the BEIR VII report. The lifetime attributable risk model was used to estimate the lifetime risk of radiation-induced breast cancer incidence and mortality. All estimates of cancer incidence and mortality were based on a population of 100 000 females followed from birth to age 80 and adjusted for the fraction that survives to various ages between 0 and 80. Assuming annual screening from ages 40 to 80 and from ages 50 to 80, the cumulative cancer incidence and mortality attributed to digital mammography, screen-film mammography, MBI, BSGI, and PEM was calculated. The corresponding cancer incidence and mortality from natural background radiation was calculated as a useful reference. Assuming a 15%-32% reduction in mortality from screening, the benefit/risk ratio for the different imaging modalities was evaluated. Results: Using conventional doses of 925 MBq Tc-99m sestamibi for MBI and BSGI and 370 MBq F-18 FDG for PEM, the cumulative cancer incidence and mortality were found to be 15-30 times higher than digital mammography. The benefit/risk ratio for annual digital mammography was Ͼ50: 1 for both the 40-80 and 50-80 screening groups, but dropped to 3:1 for the 40-49 age group. If the primary use of MBI, BSGI, and PEM is in women with dense breast tissue, then the administered doses need to be in the range 75-150 MBq for Tc-99m sestamibi and 35 MBq-70 MBq for F-18 FDG in order to obtain benefit/risk ratios comparable to those of mammography in these age groups. These dose ranges should be achievable with enhancements to current technology while maintaining a reasonable examination time. Conclusions:The results of the dose estimates in this study clearly indicate that if molecular imaging techniques are to be of value in screening for breast cancer, then the administered doses need to be substantially reduced to better match the effective doses of mammography.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: ͑15͒mentioning

confidence: 99%

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Comparison of radiation exposure and associated radiation‐induced cancer risks from mammography and molecular imaging of the breasta)

O’Connor

Rhodes

et al. 2010

Medical Physics

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“…In an effort to lower the dose to the patient, methods are being developed to increase sensitivity while maintaining resolution and tumour contrast so as to reduce injected radioactivity without the loss of image quality (O’Connor et al 2010). For this reason, the metrics for performance used in this and other similar studies have been relative sensitivity, tumour contrast, and SNR (Garibaldi et al 2006, Judy et al 2010, Hruska and O’Connor 2006, Hruska and O’Connor 2008).…”

Section: Discussionmentioning

confidence: 99%

Simulation study comparing high-purity germanium and cadmium zinc telluride detectors for breast imaging

Campbell¹,

Peterson²

2014

Phys. Med. Biol.

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We conducted simulations to compare the potential imaging performance for breast cancer detection with High-Purity Germanium (HPGe) and Cadmium Zinc Telluride (CZT) systems with 1% and 3.8% energy resolution at 140 keV, respectively. Using the Monte Carlo N-Particle (MCNP5) simulation package, we modelled both 5 mm-thick CZT and 10 mm-thick HPGe detectors with the same parallel-hole collimator for the imaging of a breast/torso phantom. Simulated energy spectra were generated, and planar images were created for various energy windows around the 140-keV photopeak. Relative sensitivity and scatter and the torso fractions were calculated along with tumour contrast and signal-to-noise ratios (SNR). Simulations showed that utilizing a ±1.25% energy window with an HPGe system better suppressed torso background and small-angle scattered photons than a comparable CZT system using a −5%/+10% energy window. Both systems provided statistically similar contrast and SNR, with HPGe providing higher relative sensitivity. Lowering the counts of HPGe images to match CZT count density still yielded equivalent contrast between HPGe and CZT. Thus, an HPGe system may provide equivalent breast imaging capability at lower injected radioactivity levels when acquiring for equal imaging time.

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“…Second, Tc-99m sestamibi doses for cardiac studies are typically more than 4-5 times greater than those currently used for MBI, 27 allowing the total MBI study to be completed in 15-20 minutes, without extension of the cardiac study examination time or extending the patient's time in the laboratory. Third, the relative uptake of Tc-99m sestamibi in organs is dependent on both regional blood flow and mitochondrial activity.…”

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confidence: 99%

Evaluation of Molecular Breast Imaging in Women Undergoing Myocardial Perfusion Imaging with Tc-99m Sestamibi

Hruska

Rhodes

Collins

et al. 2012

Journal of Women's Health

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Development of radiation dose reduction techniques for cadmium zinc telluride detectors in molecular breast imaging

Cited by 5 publications

References 0 publications

Comparison of radiation exposure and associated radiation‐induced cancer risks from mammography and molecular imaging of the breasta)

Comparison of radiation exposure and associated radiation‐induced cancer risks from mammography and molecular imaging of the breasta)

Simulation study comparing high-purity germanium and cadmium zinc telluride detectors for breast imaging

Evaluation of Molecular Breast Imaging in Women Undergoing Myocardial Perfusion Imaging with Tc-99m Sestamibi

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