Development of Pyridothiophene Compounds for PET Imaging of α‐Synuclein
Anna Pees,
Junchao Tong,
Saritha Birudaraju
et al.
Abstract:Aggregated α‐synuclein (α‐syn) protein is a pathological hallmark of Parkinson’s disease (PD) and Lewy body dementia (LBD). Development of positron emission tomography (PET) radiotracers to image α‐syn aggregates has been a longstanding goal. We the pyridothiophene scaffold for α‐syn PET radiotracers, where 47 derivatives of a potent pyridothiophene (asyn‐44; Kd = 1.85 nM) were synthesized and screened against [3H]asyn‐44 in competitive binding assays using post‐mortem PD brain homogenates. Equilibrium inhibi… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.