Development of Protein–Polymer Conjugate Nanoparticles for Modulation of Dendritic Cell Phenotype and Antigen-Specific CD4 T Cell Responses
Brianna L. Scotland,
Andrea L. Cottingham,
Jackline Joy M. Lasola
et al.
Abstract:Polymeric nanoparticles (NPs) composed of poly(lactic-co-glycolic acid) (PLGA) have found success in modulating
antigen (Ag)-specific
T cell responses for the treatment multiple immunological diseases.
Common methods by which Ags are associated with NPs are through encapsulation
and surface conjugation; however, these methods suffer from several
limitations including uncontrolled Ag loading, burst release, and
potential immune recognition. To overcome these limitations and study
the relationship between NP de… Show more
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