Development of polysaccharide-based mucoadhesive ophthalmic lubricating vehicles: The effect of different polymers on physicochemical properties and functionality

Račić, Andjelka; Čalija, Bojan; Milić, Jela; Milašinović, Nikola; Krajišnik, Danina

doi:10.1016/j.jddst.2018.10.034

Cited by 30 publications

(19 citation statements)

References 30 publications

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“…The optimal viscosity of ophthalmic solutions is recommended to be in the range of 15-50 mPa•s. 13) Contemporarily, viscosity should not exceed 30 mPa•s to avoid patient discomfort. 14) Figure 2 shows the viscosity of PVA-B-AmB and PVA-B at each gel ratio.…”

Section: Resultsmentioning

confidence: 99%

A Novel Amphotericin B Hydrogel Composed of Poly(Vinyl Alcohol)/Borate Complex for Ophthalmic Formulation

Banshoya

Shirakawa

Hieda

et al. 2023

CHEMICAL & PHARMACEUTICAL BULLETIN

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In this study, we developed a water-soluble complex-hydrogel viscosity-controlled formulation of amphotericin B (AmB). AmB is insoluble in water, but borax makes it soluble by forming a complex with AmB. Borax also forms complexes with poly(vinyl alcohol) (PVA) to produce viscous hydrogels. Furthermore, boric acid interacts with mucin expressed in corneal epithelial cells. Accordingly, by utilizing these properties of borax simultaneously, we prepared a water-soluble AmB complex-hydrogel with poly(vinyl alcohol)/ borate (PVA-B-AmB), which is suitable for eye drops. PVA-B-AmB was easily prepared by simply mixing aqueous AmB solution dissolved in borax, PVA solution, and water. The 11 B-NMR results suggested that PVA-B-AmB existed by bonding PVA and AmB via boronic acid. PVA-B-AmB (gel ratio 0.55) has a viscosity of 18.3 0.5 mPa•s and is suitable for ophthalmic formulations. This formulation exhibited sustained release of AmB of approximately 45% at 24 h. It was also shown that this formulation interacts with mucin. These results suggest that PVA-B-AmB can be used as a water-soluble AmB preparation suitable for ophthalmic use.

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Section: Resultsmentioning

confidence: 99%

A Novel Amphotericin B Hydrogel Composed of Poly(Vinyl Alcohol)/Borate Complex for Ophthalmic Formulation

Banshoya

Shirakawa

Hieda

et al. 2023

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…However, it is necessary to Martínez-Neira, A. G., & Litardo-Velásquez, C. A. (2022) (Mohammed et al, 2013;Ali et al, 2019;Račić et al, 2019).…”

Section: Methods Observes the Dangerousnessmentioning

confidence: 99%

Evaluation of mechanical risks in the labor activities of washing and lubricating vehicles

Martínez-Neira

Litardo-Velásquez²

2022

irjeis

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This research is based on occupational risk factors to Those to which workers are exposed in vehicle washers and lubricators, risk components that correspond to a current problem where working conditions and various risk factors related to work in this type of activity are identified. The same that can generate accidents or occupational diseases. Likewise, the need to take actions aimed at the prevention of this type of risk was seen, whose main objective was to identify, evaluate and propose a prevention plan, research that was carried out on two jobs, using the methodology of: Willian T Fine. Where we proceeded with the direct observation of the jobs, taking photographs and filming, which allowed the application of the method. The results showed high levels of risk in both activities, both washing and lubricating vehicles. This research instructs how primary actions can be carried out aimed at the prevention of occupational risks.

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“…Using a lubricant as API, the final system was characterized by mucoadhesiveness, improved rheology, and good physicochemical properties. Moreover, the preparation was simple and stable for more than one month [ 68 ].…”

Section: Excipients Used In Ocular Formulations For Modified Drug Deliverymentioning

confidence: 99%

Recent Advances in the Excipients Used for Modified Ocular Drug Delivery

et al. 2021

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In ocular drug delivery, maintaining an efficient concentration of the drug in the target area for a sufficient period of time is a challenging task. There is a pressing need for the development of effective strategies for drug delivery to the eye using recent advances in material sciences and novel approaches to drug delivery. This review summarizes the important aspects of ocular drug delivery and the factors affecting drug absorption in the eye including encapsulating excipients (chitosan, hyaluronic acid, poloxamer, PLGA, PVCL-PVA-PEG, cetalkonium chloride, and gelatin) for modified drug delivery.

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Development of polysaccharide-based mucoadhesive ophthalmic lubricating vehicles: The effect of different polymers on physicochemical properties and functionality

Cited by 30 publications

References 30 publications

A Novel Amphotericin B Hydrogel Composed of Poly(Vinyl Alcohol)/Borate Complex for Ophthalmic Formulation

A Novel Amphotericin B Hydrogel Composed of Poly(Vinyl Alcohol)/Borate Complex for Ophthalmic Formulation

Evaluation of mechanical risks in the labor activities of washing and lubricating vehicles

Recent Advances in the Excipients Used for Modified Ocular Drug Delivery

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