Development of polypyrrole/collagen/nano-strontium substituted bioactive glass composite for boost sciatic nerve rejuvenation
            <i>in vivo</i>

Lin, Bo; Dun, Guoqing; Jin, Dongzhu; Du, Yaowu

doi:10.1080/21691401.2019.1638794

Cited by 12 publications

(3 citation statements)

References 42 publications

(43 reference statements)

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“…In addition, the mixing of BGs into conductive biopolymers enhanced the neural cell performances at the damaged sites. To prove this, Lin et al [ 173 ]. recently developed collagen-polypyrrole copolymers containing Sr-added nanoBGs by electrospinning and assessed their in vivo performance in nerve cell regeneration.…”

Section: Application Possibilities Of Bioactive Glassesmentioning

confidence: 99%

Advanced Bioactive Glasses: The Newest Achievements and Breakthroughs in the Area

et al. 2023

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Bioactive glasses (BGs) are especially useful materials in soft and bone tissue engineering and even in dentistry. They can be the solution to many medical problems, and they have a huge role in the healing processes of bone fractures. Interestingly, they can also promote skin regeneration and wound healing. Bioactive glasses are able to attach to the bone tissues and form an apatite layer which further initiates the biomineralization process. The formed intermediate apatite layer makes a connection between the hard tissue and the bioactive glass material which results in faster healing without any complications or side effects. This review paper summarizes the most recent advancement in the preparation of diverse types of BGs, such as silicate-, borate- and phosphate-based bioactive glasses. We discuss their physical, chemical, and mechanical properties detailing how they affect their biological performances. In order to get a deeper insight into the state-of-the-art in this area, we also consider their medical applications, such as bone regeneration, wound care, and dental/bone implant coatings.

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Section: Application Possibilities Of Bioactive Glassesmentioning

confidence: 99%

Advanced Bioactive Glasses: The Newest Achievements and Breakthroughs in the Area

et al. 2023

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“…More recently, electrospun films made of polypyrrole/collagen polymers and strontium-substituted nano-sized BGs (PPY/Coll/n-Sr@BG) were evaluated for the promotion of sciatic nerve rejuvenation in vivo [68]. These constructs demonstrated a native-mimicking morphology, better porosity, and higher specific surface area than customary nerve channels, thus allowing appropriate transportation of nerve development factor and glucose, as well as hindering the section of lymphatic tissue and fibroblasts.…”

Section: Silicate-based Bgs In Peripheral Nerve Regenerationmentioning

confidence: 99%

Bioactive Glasses and Glass/Polymer Composites for Neuroregeneration: Should We Be Hopeful?

et al. 2020

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Bioactive glasses (BGs) have been identified as highly versatile materials in tissue engineering applications; apart from being used for bone repair for many years, they have recently shown promise for the regeneration of peripheral nerves as well. They can be formulated in different shapes and forms (micro-/nanoparticles, micro-/nanofibers, and tubes), thus potentially meeting the diverse requirements for neuroregeneration. Mechanical and biological improvements in three-dimensional (3D) polymeric scaffolds could be easily provided by adding BGs to their composition. Various types of silicate, borate, and phosphate BGs have been examined for use in neuroregeneration. In general, BGs show good compatibility with the nervous system compartments both in vitro and in vivo. Functionalization and surface modification plus doping with therapeutic ions make BGs even more effective in peripheral nerve regeneration. Moreover, the combination of BGs with conductive polymers is suggested to improve neural cell functions at injured sites. Taking advantage of BGs combined with novel technologies in tissue engineering, like 3D printing, can open new horizons in reconstructive approaches for the nervous system. Although there are great potential opportunities in BG-based therapies for peripheral nerve regeneration, more research should still be performed to carefully assess the pros and cons of BGs in neuroregeneration strategies.

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“…[ 3 ] Strontium has been proven in animal models to improve nerve regeneration, making it a possible treatment for nerve damage (Lin et al , 2019). [ 4 ]…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Antidiabetic Activity and Cytotoxic Effect of Strontium Nanoparticles Synthesized Using Mimosa Pudica

Vallinayaki,

Shanmugam

2024

Journal of Pharmacy and Bioallied Sciences

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Nanotechnology is emerging as a promising approach in the development of novel therapeutic strategies. Nanoparticles, due to their unique physicochemical properties and small size, have the potential to improve the delivery of therapeutic agents, enhance their bioavailability, and increase their efficacy. Among various types of nanoparticles, strontium nanoparticles have gained attention due to their potential antidiabetic activity and cytotoxic effects against cancer cells. Mimosa pudica, also known as “Sensitive Plant” or “Touch-Me-Not,” is a medicinal plant known for its diverse pharmacological activities, including antidiabetic and anticancer properties. Recent research has focused on the synthesis of strontium nanoparticles by using Mimosa pudica as a green and sustainable approach. These nanoparticles have shown promising results in terms of their antidiabetic activity and cytotoxic effects against cancer cells. Thus, in this study, the antidiabetic effect was studied using the alpha-amylase inhibitor assay, and the cytotoxic effect was studied using the brine shrimp lethality assay. In these assays, increasing concentration of Mimosa pudica-mediated strontium nanoparticles exhibited increasing antidiabetic and cytotoxic effects, which was similar to the standard used, which is acarbose. Hence, this can be used as a novel antidiabetic and cytotoxic agent in the future.

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Development of polypyrrole/collagen/nano-strontium substituted bioactive glass composite for boost sciatic nerve rejuvenation in vivo

Cited by 12 publications

References 42 publications

Advanced Bioactive Glasses: The Newest Achievements and Breakthroughs in the Area

Advanced Bioactive Glasses: The Newest Achievements and Breakthroughs in the Area

Bioactive Glasses and Glass/Polymer Composites for Neuroregeneration: Should We Be Hopeful?

Evaluation of Antidiabetic Activity and Cytotoxic Effect of Strontium Nanoparticles Synthesized Using Mimosa Pudica

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