Development of polymeric colloidal nanocarrier based on maltodextrin

Abstract

The development of nanocarriers has been the focus of many studies designed to produce novel drug delivery systems. Thus, this study describes the development and characterization of a novel delivery system denominated as polymeric colloidal nanocarriers (PCN) made up of a maltodextrin core dispersed in a continuous phase of silicone. The developed PCN were prepared following two main consecutive steps: generation of a water-in-oil nanoemulsion using a high pressure homogenizer followed by extraction of the water present in the internal phase to obtain the maltodextrin PCN dispersed in an anhydrous nanosuspension. The obtained dispersion was analyzed by dynamic turbidimetry, dynamic light scattering and scanning electron microscopy (SEM) to respectively register results related to the physical stability, the average diameter and the morphological aspect. Based on the results of the characterizations, it was possible to evidence that the use of a surfactant concentration equal or higher than solid contents improves the nanosuspension physical stability and diminishes the PCN particle size.