Development of Play Behavior in Neonatally Undernourished Rats

Loranca, Angélica; Torrero, Carmen; Salas, Manuel

doi:10.1016/s0031-9384(98)00235-2

Cited by 27 publications

(12 citation statements)

References 44 publications

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“…In the present experiment decreased body weight was observed in pups coming from the nests of restrictedly fed mothers, which is in agreement with the data reported by other authors (Babický and Nováková, 1986;Campbell and Bedi, 1989;Almeida et al, 1992;Boxwell et al, 1995;Loranca et al, 1999). e observed growth stunting was more pronounced in animals restrictedly fed during 30 days post partum (SWR group) than in both groups with a shorter period of food restriction.…”

Section: Discussionsupporting

confidence: 93%

Effect of early nutritional experience on the feeding behaviour of adult female rats

Šefčíková¹,

Mózeš²

2002

Vet. Med. - Czech

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In the present paper the effect of postnatal undernutrition on feeding behaviour has been evaluated in mature female Wistar rats subjected to food restriction a) during the suckling period, i. e. up to day 15 (SR), b) during the weaning period from day 15 to 30 (WR), c) throughout 30 days post partum (SWR) and d) during adulthood, i. e. from day 60-75 of life (AR). In comparison with the ad libitum fed controls (C), the lactating mothers and the pups of the food-restricted groups were allowed free access to food for only two hours daily. In experimental groups this restriction was then changed to an ad libitum regime. On day 90 food intake was evaluated daily in five 20 min lasting sessions after 23 h of fasting in group-housed and single-housed rats exposed to their home as well as to their experimental environment. e significantly decreased body weight found on day 30 and 90 in females coming from litters of restrictedly fed mothers, as compared with those fed ad libitum, showed that these animals were considerably undernourished. Appetitive motivation increased in those groups of females that had been exposed to a restricted feeding regime during their infant period but remained unaffected in females restrictedly fed during their adult age. In comparison with the ad libitum fed controls and AR groups, significantly increased mean food intake was observed in all postnatally underfed groups (P < 0.001). e greatest inclination to hyperphagia and qualitative changes in feeding behaviour were observed in SWR females whose feeding regime was restricted for the longest time, i. e. during the suckling and the weaning period, as compared to groups with shorter food restriction. ese animals showed hyperphagia even in the new environment regardless whether the whole group or only one female was tested. Our results reveal a) a determinant influence of the feeding regime of the animals at early age (41%) while environmental and social factors represent only about 17% and 4%, respectively and that b) changes in feeding habits in adult female rats may significantly depend on the length of postnatal undernutrition.

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Section: Discussionsupporting

confidence: 93%

Effect of early nutritional experience on the feeding behaviour of adult female rats

Šefčíková¹,

Mózeš²

2002

Vet. Med. - Czech

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“…Consistent with our findings, it has been reported that offspring with fewer littermates often receive more milk and thus experience increased postnatal growth and faster physiological development (Teicher and Kenny, 1978; Loranca et al, 1999; Bautista et al, 2010; Rödel et al, 2008), whereas pups raised in larger litters develop more slowly as a consequence of lower breast milk intake (Spencer and Tilbrook, 2009; Bautista et al, 2010; Hou et al, 2011). Early postnatal overnourishment can lead to persistent weight gain and respective changes in the regulation of hormones such as leptin and insulin (Davidowa and Plagemann, 2000).…”

Section: Discussionsupporting

confidence: 92%

Early life overnutrition induced by litter size manipulation decreases social play behavior in adolescent male rats

Carvalho¹,

Ferri

Sousa

et al. 2016

Intl J of Devlp Neuroscience

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Several studies have investigated the effects of artificial litter size adjustment on offspring development. Social play behavior is important for neurobehavioral development and is impaired in several developmental psychiatric disorders. This study therefore investigated the effect of litter size on play behavior in adolescent rats. On postnatal day (PND) 2, litters were adjusted to a small litter (SL) size of 3 pups per dam or normal litter (NL) size of 12 pups per dam. Maternal behaviors scored daily during the first week of lactation (PND2-8) revealed that arched nursing and pup licking behaviors were increased in dams with SLs versus those with NLs. SL offspring exhibited accelerated weight gain and advanced development of physical landmarks and reflexes, possibly due to overnutrition. Social isolation lasting 3.5h prior to social play behavioral testing produced a higher frequency and duration of pouncing, pinning, sniffing, and grooming in both male and female offspring. However, male SL offspring exhibited a lower frequency of pouncing and pinning when compared with male NL offspring, while no litter size-dependent differences were observed in social behaviors unrelated to play (sniffing and grooming). These findings identify a possible sexually dimorphic influence of litter size in the development of social behavior. Given that social behaviors such as play behavior are vital for normal cognitive and social development, these findings have important implications for developmental and neuropsychiatric research.

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“…Rationing the amount of food available to mother cats also increases the amount of object play exhibited by these kittens (Bateson, Mendl, & Feaver, 1990). Neonatal undernourishment in rat pups also has been reported to increase playfulness when assessed during the juvenile period (Ikemoto & Panksepp, 1992;Loranca, Torrero, & Salas, 1999). Higher levels of playfulness in juvenile rats also can result from prenatal exposure to morphine (Hol, Niesink, Van Ree, & Spruijt, 1996).…”

mentioning

confidence: 99%

Effects of neonatal handling and maternal separation on rough‐and‐tumble play in the rat

Arnold

Siviy

2002

Developmental Psychobiology

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The extent to which brief daily handling and longer periods of separation from the mother during the first 2 weeks of life can affect play behavior in juvenile rats was assessed. Rat pups were separated from the mother for either 15 min daily (handling) or for 3 hr daily (maternal separation), and play was observed as juveniles. Overall levels of playfulness were not affected by either manipulation, although certain aspects of playful responsiveness were affected in males, but not females. In particular, the pattern of responsiveness to playful contacts was feminized in both handled and separated male rats. Activity in a novel open field at 15 days of age was increased in both males and females from the separated group, but not in the handled animals, as were the number of rears exhibited during the play bouts. These data suggest that early rearing experiences can have subtle gender-dependent effects on some aspects of play in juvenile rats and that the underlying mechanism(s) responsible for these effects may differ from those associated with other effects reported for handling and maternal separation.

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Development of Play Behavior in Neonatally Undernourished Rats

Cited by 27 publications

References 44 publications

Effect of early nutritional experience on the feeding behaviour of adult female rats

Effect of early nutritional experience on the feeding behaviour of adult female rats

Early life overnutrition induced by litter size manipulation decreases social play behavior in adolescent male rats

Effects of neonatal handling and maternal separation on rough‐and‐tumble play in the rat

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