Development of piglet gut microbiota at the time of weaning influences development of postweaning diarrhea – A field study

Karasova, Daniela; Crhánová, Magdaléna; Babák, Vladimír; Jerabek, Martin; Brzobohatý, Luboš; Matesova, Zuzana; Rychlı́k, Ivan

doi:10.1016/j.rvsc.2020.12.022

Cited by 52 publications

(60 citation statements)

References 23 publications

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“…Interestingly, F. prausnitzii has also been reported to be more relatively abundant at 60 days of age in pigs weaned at 21, 28, and 42 d vs. 14 d 15 and in healthy pigs vs. those with postweaning diarrhea 26 . Butyricicoccus porcorum has been associated with higher feed efficiency as have Treponema porcinum and Treponema succinifaciens which were also more relatively abundant in weaned pigs here 27 .…”

Section: Discussionmentioning

confidence: 99%

Weaning age and its effect on the development of the swine gut microbiome and resistome

Holman

Gzyl

Mou

et al. 2021

Preprint

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Piglets are often weaned between 19 and 22 d of age in North America although in some swine operations this may occur at 14 d or less. Piglets are abruptly separated from their sow at weaning and are quickly transitioned from sow's milk to a plant-based diet. The effect of weaning age on the long-term development of the pig gut microbiome is largely unknown. In this study, pigs were weaned at either 14, 21, or 28 d of age and fecal samples collected 21 times from d 4 (neonatal) through to marketing at d 140. The fecal microbiome was characterized using 16S rRNA gene and shotgun metagenomic sequencing. The fecal microbiome of all piglets shifted significantly three to seven days post-weaning with an increase in microbial diversity. Several Prevotella spp. increased in relative abundance immediately after weaning as did butyrate-producing species such as Butyricicoccus porcorum, Faecalibacterium prausnitzii, and Megasphaera elsdenii. Within 7 days of weaning, the gut microbiome of pigs weaned at 21 and 28 days of age resembled that of pigs weaned at 14 d. Resistance genes to most antimicrobial classes decreased in relative abundance post-weaning with the exception of those conferring resistance to tetracyclines and macrolides-lincosamides-streptogramin B. The relative abundance of microbial carbohydrate-active enzymes (CAZymes) changed significantly in the post-weaning period with an enrichment of CAZymes involved in degradation of plant-derived polysaccharides. These results demonstrate that pigs tend to have a more similar microbiome as they age and that weaning age has only a temporary effect on the gut microbiome.

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Section: Discussionmentioning

confidence: 99%

Weaning age and its effect on the development of the swine gut microbiome and resistome

Holman

Gzyl

Mou

et al. 2021

Preprint

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“…Interestingly, F . prausnitzii has also been reported to be more relatively abundant at 60 days of age in pigs weaned at 21, 28, and 42 days versus 14 days ( 15 ) and in healthy pigs versus those with postweaning diarrhea ( 26 ). Butyricicoccus porcorum has been associated with higher feed efficiency, as have Treponema porcinum and Treponema succinifaciens , which were also more relatively abundant in weaned pigs here ( 27 ).…”

Section: Discussionmentioning

confidence: 99%

Weaning Age and Its Effect on the Development of the Swine Gut Microbiome and Resistome

et al. 2021

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“…hyointestinalis,and C. fetus are capable to cause irritation in the intestinal tract of calves and induce diarrhea (Firehammer and Myers, 1981;Diker et al, 1990). Previous studies reported that Negativicutes, Veillonella, and Fusobacterium were more abundant in diarrheic piglets compared to healthy weaned piglets (Huang et al, 2019;Karasova et al, 2021). In human studies, Tyzzerella contribute to neuroinflammation and its increase is associated with diarrhea (Nakajima et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

The Gut Microbiota of Newborn Calves and Influence of Potential Probiotics on Reducing Diarrheic Disease by Inhibition of Pathogen Colonization

et al. 2021

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Calf diarrhea is one of the most concerning challenges facing both the dairy and beef cattle industry. Maintaining healthy gut microbiota is essential for preventing gastrointestinal disorders. Here, we observed significantly less bacterial richness in the abnormal feces with watery or hemorrhagic morphology compared to the normal solid feces. The normal solid feces showed high relative abundances of Osllospiraceae, Christensenellaceae, Barnesiella, and Lactobacillus, while the abnormal feces contained more bacterial taxa of Negativicutes, Tyzzerella, Parasutterella, Veillonella, Fusobacterium, and Campylobacter. Healthy calves had extensive bacterial-bacterial correlations, with negative correlation between Lactobacillus and potential diarrheagenic Escherichia coli-Shigella, but not in the abnormal feces. We isolated Lactobacillus species (L. reuteri, L. johnsonii, L. amylovorus, and L. animalis), with L. reuteri being the most abundant, from the healthy gut microbiota. Isolated Lactobacillus strains inhibited pathogenic strains including E. coli K88 and Salmonella Typhimurium. These findings indicate the importance of a diverse gut microbiota in newborn calf’s health and provide multiple potential probiotics that suppress pathogen colonization in the gastrointestinal tract to prevent calf diarrhea.

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Development of piglet gut microbiota at the time of weaning influences development of postweaning diarrhea – A field study

Cited by 52 publications

References 23 publications

Weaning age and its effect on the development of the swine gut microbiome and resistome

Weaning age and its effect on the development of the swine gut microbiome and resistome

Weaning Age and Its Effect on the Development of the Swine Gut Microbiome and Resistome

The Gut Microbiota of Newborn Calves and Influence of Potential Probiotics on Reducing Diarrheic Disease by Inhibition of Pathogen Colonization

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