Development of Phyto‐Antidotes Against Adverse Chemical Agents

Lysiuk, Roman; Oliynyk, Petro; Antonyak, Halyna; Voronenko, D. V.

doi:10.1002/9781119650034.ch12

Cited by 3 publications

(1 citation statement)

References 59 publications

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“…Antioxidants/Polyphenolics Antioxidant-containing foods may offer promising therapeutic benefits in autism. 53 Studies have suggested that supplementation with antioxidants (such as polyphenolics, flavonoids) ameliorates symptoms of autism, 54,55 but the evidence is not sufficient to recommend an antioxidant-based therapeutic practice for autism.…”

Section: Dietary Interventions In Autismmentioning

confidence: 99%

Dietary interventions for autism spectrum disorder: An updated systematic review of human studies

et al. 2022

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Autism is a complex spectrum of disorders (ASD) with genetic, epigenetic, autoimmune, oxidative stress, and environmental aetiologies. Treatment of ASD using dietary approaches is a promising strategy, especially owing to its safety and availability. Our study critically analysed the roles and efficacy of antioxidants, probiotics, prebiotics, camel milk and vitamin D. This systematic review provides an updated synopsis of human studies that investigated therapeutic benefits of these dietary interventions in autism. A total of 943 papers were identified out of which 21 articles were included in the systematic review. The selected studies investigated the impact of 5 different dietary supplementations in ASD symptoms and behaviours. These agents include; antioxidants/polyphenolic compounds, probiotics, prebiotics, camel milk and vitamin D. From the results of the present review, antioxidants/polyphenolic compounds decreased the levels of inflammatory cytokines and improved behavioural symptoms. Probiotics improved behavioural and GI symptoms as well as restored gut microbiota equilibrium. Prebiotics decreased levels of inflammatory cytokines, improved behavioural and GI symptoms and improved gut microbiota. Vitamin D improved behavioural symptoms and offered protective effects against neurotoxicity. Camel milk reduced inflammatory responses and oxidative stress. Given the chronic nature as well as early onset of ASD, dietary supplements become useful to complement nutritional deficiencies in children with ASD. Key benefits of these agents stem from their ability to target multiple physiological areas via the gut brain-axis while they are devoid of potential harmful or aggravating effects on ASD patients. The evidence collated in this review propose that dietary intervention may provide a new platform for the management of autism.

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Section: Dietary Interventions In Autismmentioning

confidence: 99%

Dietary interventions for autism spectrum disorder: An updated systematic review of human studies

et al. 2022

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The Effects of Fisetin and Curcumin on Oxidative Damage Caused by Transition Metals in Neurodegenerative Diseases

Bjørklund,

Oliinyk,

Khavrona

et al. 2024

Mol Neurobiol

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Ellagic Acid: A Review on Its Natural Sources, Chemical Stability, and Therapeutic Potential

Sharifi‐Rad

Quispe

Castillo

et al. 2022

Oxidative Medicine and Cellular Longevity

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163

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Ellagic acid (EA) is a bioactive polyphenolic compound naturally occurring as secondary metabolite in many plant taxa. EA content is considerable in pomegranate (Punica granatum L.) and in wood and bark of some tree species. Structurally, EA is a dilactone of hexahydroxydiphenic acid (HHDP), a dimeric gallic acid derivative, produced mainly by hydrolysis of ellagitannins, a widely distributed group of secondary metabolites. EA is attracting attention due to its antioxidant, anti-inflammatory, antimutagenic, and antiproliferative properties. EA displayed pharmacological effects in various in vitro and in vivo model systems. Furthermore, EA has also been well documented for its antiallergic, antiatherosclerotic, cardioprotective, hepatoprotective, nephroprotective, and neuroprotective properties. This review reports on the health-promoting effects of EA, along with possible mechanisms of its action in maintaining the health status, by summarizing the literature related to the therapeutic potential of this polyphenolic in the treatment of several human diseases.

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Development of Phyto‐Antidotes Against Adverse Chemical Agents

Cited by 3 publications

References 59 publications

Dietary interventions for autism spectrum disorder: An updated systematic review of human studies

Dietary interventions for autism spectrum disorder: An updated systematic review of human studies

The Effects of Fisetin and Curcumin on Oxidative Damage Caused by Transition Metals in Neurodegenerative Diseases

Ellagic Acid: A Review on Its Natural Sources, Chemical Stability, and Therapeutic Potential

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