Development of physical, mechanical, antibacterial and cell growth properties of poly(glycerol sebacate urethane) (PGSU) with helping of curcumin and hydroxyapatite nanoparticles

Abstract

Biocompatible and antimicrobial elastomers with controlled hydrophilicity and degradation rate, as well as appropriate stiffness and elasticity, are interesting for biomedical applications, such as regenerative medicine and tissue engineering.

Preparation and characterization of a new bio nanocomposites based poly(glycerol sebacic‐urethane) containing nano‐clay (Cloisite Na+) and its potential application for tissue engineering

“…PGS pre-polymer and PGSU film was synthesized following our previously published papers 21,39 with some modification. Briefly, the pre-PGS synthesis was started by mixing glycerol and sebacic acid (equimolar) at 130 C under a nitrogen atmosphere for 1 h. The pressure was then reduced, and the reaction was allowed to continue for 24 h to yield a yellow viscose resin.…”

“…Our previous work showed that the addition of hydroxyapatite to the PGSU network could noticeably improve the mechanical performance and hydrophilicity of PGSU scaffolds. 21 Furthermore, the impact of other kinds of nanoparticles such as titanium dioxide (TiO 2 ), 22 multi-walled carbon nanotubes (MWCNTs), 23 nanosilica, 24 halloysite nanotubes, 25 and cellulose nanocrystals (CNCs) 26 on the mechanical and surface properties, biodegradation rate, as well as in-vitro and in-vivo cell metabolic activity have been reported previously. Nevertheless, to the best of our knowledge, the nanocomposites comprising sodium montmorillonite (Cloisite Na + ) and PGSU with TE application has not been reported yet.…”

Conductive poly(ε‐caprolactone)/polylactic acid scaffolds for tissue engineering applications: Synergy effect of zirconium nanoparticles and polypyrrole

“…The water uptake capacity in an aqueous media was investigated by immersing the scaffolds in PBS solution (37°C, 24 h). The swelling ratio was determined according to Equation (2) 29 : where W 0 is the initial weight of scaffolds before swelling and W s is the mass of the swollen scaffolds.…”

“…The weight loss of the samples during the degradation was recorded at predetermined time intervals (5‐day periods). Finally, degradation of each sample was calculated through Equation (3) 29 : where W i is the initial weight of the scaffold, and W d is the weight of the dried sample at each time.…”

“…The weight loss of the samples during the degradation was recorded at predetermined time intervals (5-day periods). Finally, degradation of each sample was calculated through Equation ( 3) 29 :…”