Development of photocrosslinked polyacrylic acid hydrogel as an adhesive for dermatological patches: Involvement of formulation factors in physical properties and pharmacological effects

Onuki, Yoshinori; Nishikawa, Masato; Morishita, Mariko; Takayama, Kozo

doi:10.1016/j.ijpharm.2007.07.021

Cited by 41 publications

(32 citation statements)

References 24 publications

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“…Cross-linked networks of synthetic polymers such as polyethylene oxide (PEO) (Khoylou & Naimian, 2009), polyvinyl pyrollidone (PVP) (Razzak et al, 2001), polylactic acid (PLA) (Palumbo et al, 2006), , polyacrylic acid (PAA) (Onuki et al, 2008), polymethacrylate (PMA) (Yang et al), polyethylene glycol (PEG) (Singh et al), or natural biopolymers (Coviello et al, 2007) such as alginate, chitosan, carrageenan, hyaluronan, and carboxymethyl cellulose (CMC) have been reported. The various preparation techniques adopted are physical crosslinking (Hennink & Nostrum, 2002), chemical cross-linking (Barbucci et al, 2004), grafting polymerisation (Said et al, 2004), and radiation cross-linking (Fei et al, 2000;Liu et al, 2002b).…”

Section: Methods To Produce Hydrogelmentioning

confidence: 99%

Hydrogels: Methods of Preparation, Characterisation and Applications

Gulrez¹,

Al-Assaf²,

Phillips³

2011

Progress in Molecular and Environmental Bioengineering - From Analysis and Modeling to Technology Applications

253

178

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Section: Methods To Produce Hydrogelmentioning

confidence: 99%

Hydrogels: Methods of Preparation, Characterisation and Applications

Gulrez¹,

Al-Assaf²,

Phillips³

2011

Progress in Molecular and Environmental Bioengineering - From Analysis and Modeling to Technology Applications

253

178

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“…Photocrosslinkable PAA-HEMA was synthesized according to a method described previously (7,8). In brief, after the elimination of the inhibitor by filtration, 3.61 g of HEMA was added to 2.00 g of PAA dissolved in purified water, and the mixture was stirred.…”

Section: Synthesis Of Photocrosslinkable Polymersmentioning

confidence: 99%

“…The gel fraction and degree of swelling were measured according to previous reports (7,8). Photocrosslinked PAA hydrogels of 0.5 g (weight of the solid content, W solid ) on a polystyrene disk were equilibrated in 60 ml of purified water for 24 h at room temperature and then weighed after the excess water was carefully removed (W water ).…”

Section: Gel Fraction and Degree Of Swellingmentioning

confidence: 99%

“…Therefore, the value of the gel fraction decreases with a decrease in gel formation. The degree of swelling is affected by numerous factors, such as crosslink density (7), entanglement of the polymer chains (8), and the hydrophilicity of the polymer (8). In general, because a solid hydrogel swells less in water, we can estimate the mechanical strength of the hydrogel from the degree of swelling.…”

Section: Effect Of Preparation Conditions On Formulation Propertiesmentioning

confidence: 99%

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Formulation Optimization of an Indomethacin-Containing Photocrosslinked Polyacrylic Acid Hydrogel as an Anti-inflammatory Patch

Nishikawa

Onuki

Isowa³

et al. 2008

AAPS PharmSciTech

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Abstract. Photocrosslinked polyacrylic acid hydrogel, made from polyacrylic acid (PAA) modified with 2-hydroxyethyl methacrylate (HEMA), is a promising candidate adhesive for dermatological patches. In this study, we investigated the further availability of hydrogel as an adhesive for dermatological patches using a hydrogel containing indomethacin (IDM) as a model anti-inflammatory patch. From an orthogonal experimental study, we clarified the relationships between formulation factors and characteristics of model formulation. Formulations with a lower degree of swelling were prepared by increasing the degree of HEMA modification and the addition of Tween 80. Apparent permeation rate was increased by addition of L-menthol and Tween 80. A tendency for higher HEMA modification to be accompanied by the prolongation of the lag time of IDM was observed. To obtain an applicable antiinflammatory patch, we conducted a formulation optimization study using a novel optimization method, a response-surface method incorporating multivariate spline interpolation (RSM-S). Consequently, a highly functional anti-inflammatory patch in terms of its adhesive properties and bioavailability was successfully obtained. Since a wide range of functions can be fully controlled by manipulating the formulation factors, photocrosslinked polyacrylic acid hydrogel is an attractive candidate adhesive for dermatological patches.

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“…The various crosslinked networks of synthetic polymers such as polyethylene oxide (PEO) (Razzak et al, 2001), polyvinyl pyrrolidone (PVP; Palumbo et al, 2006), polylactic acid (Onuki et al, 2008), polyacrylic acid (PAA; Yang et al, 2009), polymethacrylate (Singh & Vashishth, 2008) polyethylene glycol (PEG; Peppas & Khare, 1993) or natural biopolymers, such as hyaluronic acid, pectin, chondroitin sulfate, alginic acid, carrageenan have been prepared using different techniques like solution polymerization or crosslinking (Fei et al, 2000), irradiation crosslinking (Hennink & Nostrum, 2002;Liu et al, 2002), physical crosslinking (Yoshii & Kume, 2003), suspension polymerization and grafting polymerization (Witchterle & Lim, 1960).…”

Section: Preparation Of Hydrogelsmentioning

confidence: 99%

Stimuli-responsive hydrogels in drug delivery and tissue engineering

Sood¹,

Bhardwaj²,

Mehta³

et al. 2014

Drug Delivery

308

194

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Hydrogels are the three-dimensional network structures obtained from a class of synthetic or natural polymers which can absorb and retain a significant amount of water. Hydrogels are one of the most studied classes of polymer-based controlled drug release. These have attracted considerable attention in biochemical and biomedical fields because of their characteristics, such as swelling in aqueous medium, biocompatibility, pH and temperature sensitivity or sensitivity towards other stimuli, which can be utilized for their controlled zero-order release. The hydrogels are expected to explore new generation of self-regulated delivery system having a wide array of desirable properties. This review highlights the exciting opportunities and challenges in the area of hydrogels. Here, we review different literatures on stimuli-sensitive hydrogels, such as role of temperature, electric potential, pH and ionic strength to control the release of drug from hydrogels.

show abstract

Development of photocrosslinked polyacrylic acid hydrogel as an adhesive for dermatological patches: Involvement of formulation factors in physical properties and pharmacological effects

Cited by 41 publications

References 24 publications

Hydrogels: Methods of Preparation, Characterisation and Applications

Hydrogels: Methods of Preparation, Characterisation and Applications

Formulation Optimization of an Indomethacin-Containing Photocrosslinked Polyacrylic Acid Hydrogel as an Anti-inflammatory Patch

Stimuli-responsive hydrogels in drug delivery and tissue engineering

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