Development of pH-driven zein/tea saponin composite nanoparticles for encapsulation and oral delivery of curcumin

Tremella polysaccharides-coated zein nanoparticles for enhancing stability and bioaccessibility of curcumin

“…Another possibility is that the combination of curcumin with nonpolar patches on the surfaces of peptides hydrolyzed from proteins can also lead to increased gastrointestinal solubility of curcumin. The result is in accordance with the study carried out by Yuan et al (2021) , who demonstrated the bioaccessibility of curcumin in zein NPs coated with tea saponins was 60.83%, which was significantly higher than that of free curcumin (below 15%). However, the release rates of curcumin loaded in zein/sodium alginate and zein/sodium caseinate NPs fabricated by pH-driven method were above 90% ( Li et al (2021) .…”

“…Bioaccessibility was evaluated through an in vitro model of gastrointestinal digestion ( Wei et al, 2019b ). The bioaccessibility of curcumin can be denoted as the percentage of curcumin released into the micellar phase after in vitro gastrointestinal digestion ( Yuan et al, 2021 ; Zou et al, 2021 ). Curcumin, a highly hydrophobic bioactive substance, is usually absorbed only after being dissolved in gastrointestinal fluids.…”

“…The sample was adjusted back to pH 7.5 and gently agitated in a water bath at 37 °C for 2 h. After simulated gastrointestinal digestion, the resulting digestion dispersions were centrifuged at 10000 rpm under 10 °C for 40 min. The supernatant (micelle phase) was carefully extracted for evaluation of curcumin bioaccessibility ( Yuan et al, 2021 ). The absorbance of the supernatant (micelle phase) at 426 nm was ascertained using the UV-2355 spectrophotometer to obtain the concentration of curcumin.…”

Formation and Physical Stability of Zanthoxylum bungeanum Essential Oil Based Nanoemulsions Co-Stabilized with Tea Saponin and Synthetic Surfactant

“…Thus, it could be speculated that there was a synergistic effect in ZBEO nanoemulsion co-stabilized by Tween 40 and TS at certain TS concentrations. Similar results in different types of colloid dispersions have been investigated, where TS decreased droplet size at low content and interfered the droplets formation at high content [24]. With incorporation of TS, it adsorbed in the oil droplets surface, thereby stabilizing the oil droplets; thus, it is difficult to reduce the droplet size [10].…”

“…Long, et al [23] evaluated the ability of TS to form and stabilize nanosuspensions and investigated the feasibility of TS as a cryoprotectant of hesperidin solid nanocrystals. Yuan, et al [24] produced the pH-driven binary composite nanoparticles based on zein and TS without any organic reagents and high-energy equipment. Nevertheless, to the best of our knowledge, the emulsifying property and physical stability of ZBEO based nanoemulsions using TS with synthetic surfactants have not been investigated and discussed.…”