Development of periarticular osteophytes in experimentally induced osteoarthritis in the dog. A study using microradiographic, microangiographic, and fluorescent bone-labelling techniques.

Gilbertson, E M

doi:10.1136/ard.34.1.12

Cited by 150 publications

(44 citation statements)

References 8 publications

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“…It has been suggested that osteophytes result from the abnormal healing response of subchondral trabeculae, or from the blood vessels penetration into the degrading cartilage [66]. It has been also shown that in OA the patient's osteophytes express TGF-β, which induces osteophyte formation in an experimental model [67,68].…”

Section: Adipocytokines In Osteophyte Formationmentioning

confidence: 95%

The role of adipocytokines in the pathogenesis of knee joint osteoarthritis

Richter

Trzeciak

Owecki

et al. 2015

International Orthopaedics (SICOT)

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Osteoarthritis (OA) is one of the most common causes of musculoskeletal disability in the world. Traditionally, it has been thought that obesity contributes to the development and progression of OA by increased mechanical load of the joint structures. Nevertheless, studies have shown that adipose tissue-derived cytokines (adipocytokines) are a possible link between obesity and OA. Furthermore, according to recent findings, not only articular cartilage may be the main target of these cytokines but also the synovial membrane, subchondral bone and infrapatellar fat pad may be encompassed in the process of degradation. This review presents the most recent reports on the contribution of adipocytokines to the knee joint cartilage degradation, osteophyte formation, infrapatellar fat pad alterations and synovitis.

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Section: Adipocytokines In Osteophyte Formationmentioning

confidence: 95%

The role of adipocytokines in the pathogenesis of knee joint osteoarthritis

Richter

Trzeciak

Owecki

et al. 2015

International Orthopaedics (SICOT)

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“…Although dynamic histomorphometry indices in the SCB were not examined in detail, a much reduced amount of fluorochrome labeling (evaluated subjectively) in this compartment compared with the osteophyte bone led these authors to conclude that SCB proliferation of bone did not play a role in the development of osteophytes. Gilbertson reported similar results regarding early osteophyte formation; however, that study also included subjective evaluation of bone labels in dogs up to 48 weeks post operatively, at which time areas of active bone formation still were evident [17]. Subchondral deposition of new bone as well as bone remodeling also was noted, but was reduced compared with the bone of osteophytes and occurred later in the time course of osteophyte development Increased bone turnover activity also was noted in the trabecular bone of the distal end of the femur, beginning approximately three weeks after surgery.…”

Section: Discussionmentioning

confidence: 73%

“…There are relatively few studies that have investigated bone turnover by histomorphometry in periarticular osteophytes, particularly in non-rodent species, with which the present data may be compared; however, several studies have focused on osteophyte development following transection of the cranial cruciate ligament in dogs [16,17]. One of these was a short-term study that reported that osteophyte growth started shortly after surgery and bone formation reached a peak at 30-40 days; however, all dogs that underwent surgery had active bone formation/ growth within the osteophytes at the time of euthanasia (13 to 57 days post-op) [16].…”

Section: Discussionmentioning

confidence: 99%

Effects of long-term estrogen replacement therapy on bone turnover in periarticular tibial osteophytes in surgically postmenopausal cynomolgus monkeys

Olson

Lindgren

Carlson

2008

Bone

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The aims of the present study were to assess the effects of long-term estrogen replacement therapy (ERT) on size and indices of bone turnover in periarticular osteophytes in ovariectomized cynomolgus monkeys and to compare dynamic indices of bone turnover in osteophyte bone with those of subchondral bone (SCB) and epiphyseal/metaphyseal cancellous (EMC) bone. One hundred sixty-five adult female cynomolgus macaques were bilaterally ovariectomized and randomly divided into three age-and weight-matched treatment groups for a 36-month treatment period. Group 1 (OVX control) received no treatment, Group 2 (SPE) received soy phytoestrogens, and Group 3 (ERT) received conjugated equine estrogens in the diet; all monkeys were labeled with calcein before necropsy. A midcoronal, plastic-embedded section of the right proximal tibia from 20 randomly selected animals per treatment group was examined histologically. Forty-nine of the sections (OVX control, n=16; SPE, n=16; ERT, n=17) contained lateral abaxial osteophytes, and static and dynamic histomorphometry measurements were taken from osteophyte bone, SCB from the lateral tibial plateau, and EMC bone. Data were analyzed using the ANOVA and Kruskal-Wallis test, correlation and regression methods, and the Friedman and Wilcoxon signed rank test. There was no significant effect of long-term ERT on osteophyte area or on any static or dynamic histomorphometry parameters. The bone volume, trabecular number, and trabecular thickness in osteophyte bone were considerably higher than in EMC bone; whereas, trabecular separation was considerably lower in osteophyte bone. In all three treatment groups, BS/BV was significantly lower in osteophyte bone vs. EMC bone and significantly higher in osteophyte bone vs. lateral SCB. We conclude that osteophyte area and static and dynamic histomorphometry parameters within periarticular tibial osteophytes in ovariectomized cynomolgus monkeys are not significantly influenced by long-term ERT, but that site differences in static and dynamic bone histomorphometry parameters exist, particularly between EMC and osteophyte bone.

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“…Osteophytes, which represent fibrocartilaginous and skeletal outgrowths, may appear before cartilage damage or JSN becomes apparent 15 , as suggested previously by Kellgren and Lawrence in their grade 2 classification of OA, where there is a definite osteophyte - which defines the disease radiographically- but no definite JSN on radiographs 1 . Further, a strong association between the degree of cartilage damage and the size of osteophytes was previously demonstrated 2 , which supports the basis of the Kellgren and Lawrence grading scheme 1 , i.e.…”

Section: Discussionmentioning

confidence: 77%

Is the atrophic phenotype of tibiofemoral osteoarthritis associated with faster progression of disease? The MOST study

Crema

Felson

Guermazi

et al. 2017

Osteoarthritis and Cartilage

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Objective To assess the associations of atrophic tibiofemoral osteoarthritis (OA) with progression of radiographic joint space narrowing (JSN) and magnetic resonance imaging (MRI)-defined progression of cartilage damage. Design Participants of the Multicenter Osteoarthritis (MOST) Study with available radiographic and MRI assessments at baseline and 30 months were included. The atrophic OA phenotype was defined as OARSI grades 1 or 2 for JSN and grade 0 for osteophytes. Based on MRI, atrophic OA was defined as tibiofemoral cartilage damage grades ≥ 3 in at least 2 of 10 subregions with absent or tiny osteophytes in all tibiofemoral subregions. Progression of JSN and cartilage loss on MRI, was defined as 1) no, 2) slow, and 3) fast progression. Co-variance and logistic regression with generalized estimated equations were performed to assess the association of atrophic knee OA with any progression, compared to non-atrophic OA knees. Results A total of 476 knees from 432 participants were included. There were 50 (10.5%) knees with atrophic OA using the radiographic definition, and 16 (3.4%) knees with atrophic OA using MRI definition. Non-atrophic OA knees more commonly exhibited fast progression of JSN and cartilage damage. Logistic regression showed that the atrophic phenotype of knee OA was associated with a decreased likelihood of progression of JSN and cartilage loss. Conclusion In this sample, the atrophic phenotype of knee OA was associated with a decreased likelihood of progression of JSN and cartilage loss compared to the non-atrophic knee OA phenotype.

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Development of periarticular osteophytes in experimentally induced osteoarthritis in the dog. A study using microradiographic, microangiographic, and fluorescent bone-labelling techniques.

Cited by 150 publications

References 8 publications

The role of adipocytokines in the pathogenesis of knee joint osteoarthritis

The role of adipocytokines in the pathogenesis of knee joint osteoarthritis

Effects of long-term estrogen replacement therapy on bone turnover in periarticular tibial osteophytes in surgically postmenopausal cynomolgus monkeys

Is the atrophic phenotype of tibiofemoral osteoarthritis associated with faster progression of disease? The MOST study

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