Development of oral cancer tissue-mimicking phantom based on polyvinyl chloride plastisol and graphite for terahertz frequencies

Zhang, Tianmiao; Nazarov, Ravshanjon; Попов, А. П.; Demchenko, Petr; Bykov, Alexander; Grigorev, Roman; Kuzikova, Anna V.; Soboleva, V. Yu.; Zykov, Dmitry; Meglinski, Igor; Khodzitskiy, M.

doi:10.1117/1.jbo.25.12.123002

Cited by 11 publications

(6 citation statements)

References 27 publications

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“…Due to the challenges associated with obtaining human tissue for THz imaging experimental studies, a couple of studies have explored the development of tissue models, also known as phantoms. The THz imaging of phantoms have been investigated in cancer detection studies including [109], [135], [136], [137], [138], and [139].…”

Section: ) Thz Imaging Of Phantomsmentioning

confidence: 99%

Terahertz Imaging and Sensing for Healthcare: Current Status and Future Perspectives

Gezimati

Singh

2023

IEEE Access

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There is a keen interest in the exploration of new generation emitters and detectors due to advancements in innovation of new materials and device processing technologies which have opened up new frontiers in the Terahertz (THz) spectrum. Therefore, it is necessary to review the developments in THz technology for healthcare applications, their impact, implications and prospects for ongoing research and development. This paper provides a broad overview of the current status and prospects of application of THz imaging and sensing for the healthcare domain. We present current knowledge, identify existing challenges for wide scale clinical adoption of THz systems and prospective opinions to facilitate research and development towards optimized and miniaturized THz systems and biosensors that provide real operational convenience through emerging trends. Firstly, we provide an overview of the THz imaging and sensing techniques that exploit properties of THz generation and detection with emphasis on terahertz time domain spectroscopy (THz-TDS) and THz Metamaterials. The mechanisms of tissue image contrast and the application of THz imaging and sensing for biomedical applications in particular, the cancer detection application is reported. Secondly, an outlook toward the advancements in THz technology in the interface of healthcare 4.0 and its enabling technologies is explored for next generation smart and connected healthcare systems. Third, we identify the merits and existing challenges in THz cancer imaging and sensing and suggest prospective opinions to pave way to ongoing and future research. Further, we discuss the recent advances in THz imaging development and the contribution of near-field techniques based on plasmonic, and resonance based metasurfaces, waveguides etc. for breaking the diffraction limit towards development of THz systems that are convenient for point of care. We bring researchers a roadmap for future research scope.

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Section: ) Thz Imaging Of Phantomsmentioning

confidence: 99%

Terahertz Imaging and Sensing for Healthcare: Current Status and Future Perspectives

Gezimati

Singh

2023

IEEE Access

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“…A common strategy relies on the fabrication of tissue-mimicking materials known as phantoms. Typically, they consist of a bulk material with embedded scattering particles and absorbers or refractive structures that allow tuning the retina-mimicking material properties including optical, texture, elasticity, or blood flow properties [ 22 – 30 ]. To simulate three-dimensional heterogeneities commonly seen in retina tissue, various phantoms have been reported made of micrometer-sized layers, e.g., based on silicone or polymers like polydimethylsiloxane (PDMS) [ 28 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

Durable 3D murine ex vivo retina glaucoma models for optical coherence tomography

Barroso,

Ketelhut,

Nettels-Hackert

et al. 2023

Biomed. Opt. Express

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Durable and standardized phantoms with optical properties similar to native healthy and disease-like biological tissues are essential tools for the development, performance testing, calibration and comparison of label-free high-resolution optical coherence tomography (HR-OCT) systems. Available phantoms are based on artificial materials and reflect thus only partially ocular properties. To address this limitation, we have performed investigations on the establishment of durable tissue phantoms from ex vivo mouse retina for enhanced reproduction of in vivo structure and complexity. In a proof-of-concept study, we explored the establishment of durable 3D models from dissected mouse eyes that reproduce the properties of normal retina structures and tissue with glaucoma-like layer thickness alterations. We explored different sectioning and preparation procedures for embedding normal and N-methyl-D-aspartate (NMDA)-treated mouse retina in transparent gel matrices and epoxy resins, to generate durable three-dimensional tissue models. Sample quality and reproducibility were quantified by thickness determination of the generated layered structures utilizing computer-assisted segmentation of OCT B-scans that were acquired with a commercial HR-OCT system at a central wavelength of 905 nm and analyzed with custom build software. Our results show that the generated 3D models feature thin biological layers close to current OCT resolution limits and glaucoma-like tissue alterations that are suitable for reliable HR-OCT performance characterization. The comparison of data from resin-embedded tissue with native murine retina in gels demonstrates that by utilization of appropriate preparation protocols, highly stable samples with layered structures equivalent to native tissues can be fabricated. The experimental data demonstrate our concept as a promising approach toward the fabrication of durable biological 3D models suitable for high-resolution OCT system performance characterization supporting the development of optimized instruments for ophthalmology applications.

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“…Current research works are mainly based on freshly excised oral tissue, and they have rarely been explored based on organotypic models [26] [27]. Tianmiao et .al [27] proposed an oral cancer phantom without water content by applying graphite powders into a polyvinyl chloride plastisol matrix to study the THz optical properties.…”

Section: Introductionmentioning

confidence: 99%

Terahertz Characterization of Ordinary and Aggressive Types of Oral Squamous Cell Carcinoma as a Function of Cancer Stage and Treatment Efficiency

Nourinovin,

Rahman,

Philpott

et al. 2023

IEEE Trans. Instrum. Meas.

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Oral squamous cell carcinoma (OSCC) has asymptomatic characteristics that make it challenging to identify in the early stages and lead to metastatic effects. Terahertz (THz) spectroscopy and imaging are recognized as a novel technique for early cancer detection due to the non-ionizing nature and the significant THz wave absorption by water's hydrogen bonds and the higher hydration of tumours. Despite this potential, there is a lack of research on the THz characterisation of oral cancer with various essential biological conditions. THz characterisation based on frozen, freshly excised tissue restricts parametric studies on important components and diverse biological situations. Therefore, we cultivated the three-dimensional (3D), organotypic model of the OSCC, to investigate the THz spectroscopy of the tumour at various phases and the effects of the anticancer drug AG1478 on its THz spectra. Moreover, we have compared the characterisation of OSCC with two levels of aggressiveness and we contrasted how well the medication worked on these two types of cell lines. The measurements were performed at the frequency range of 0.4 to 1.6 THz, and with increasing malignancy of the samples, we observed higher refractive index, absorption coefficient, and complex permittivity than normal tissue. The results demonstrates that whereas AG1478 shifts the THz spectra in the direction of the normal tissue, it has no effect on aggressive OSCC (AOSCC) under the same circumstances. These findings may contribute to techniques that diagnose and detect tumours at the early stage.

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Development of oral cancer tissue-mimicking phantom based on polyvinyl chloride plastisol and graphite for terahertz frequencies

Cited by 11 publications

References 27 publications

Terahertz Imaging and Sensing for Healthcare: Current Status and Future Perspectives

Terahertz Imaging and Sensing for Healthcare: Current Status and Future Perspectives

Durable 3D murine ex vivo retina glaucoma models for optical coherence tomography

Terahertz Characterization of Ordinary and Aggressive Types of Oral Squamous Cell Carcinoma as a Function of Cancer Stage and Treatment Efficiency

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