“…Unfortunately, first-line anti-TB drugs are not available intravenously in many of the high TB burden countries, including Brazil. Oral administration of TB drugs is not recommended for patients in ICU [ 5 , 12 ], so in the absence of other therapeutic options, the crushing and nasogastric tube administration of fixed-dose combination (FDC) tablets (rifampin, isoniazid, pyrazinamide and ethambutol) is used. Despite the successful use of FDC tablets in outpatients [ 13 ], it limits the opportunity to tailor doses in special cases, including ICU patients, patients with kidney injury, obese patients or those whose recovery is not progressing as expected.…”