Development of olive oil based organogels using sorbitan monopalmitate and sorbitan monostearate: A comparative study

Abstract

The present work deals with preparation of the olive oil (OO) based organogels using sorbitan monostearate (SMS) and sorbitan monopalmitate (SMP) as organogelators for controlled drug delivery applications. Metronidazole (MZ) was used as the model drug. Gels were prepared by solubilizing the organogelators in OO at 60°C under stirring. As the solution was cooled down, the gelator molecules precipitate as an isotropic phase having networked structures, which immobilized OO. Formation of 3D networked structure was confirmed by light, phase contrast, and scanning electron microscopy. Accelerated thermal stability studies demonstrated the thermal stability and thermoreversibility of the organogels. DSC and gel disintegration studies suggested that the SMS based organogels were having higher thermal and physical strength as compared to the SMP based organogels. Viscometric analysis suggested the pseudoplastic flow behavior of the gels. The SMS organogels were more amorphous as compared to the SMP organogels of same composition. Drug release from the organogels followed Fickian diffusion kinetics. The drug loaded gels have shown good antimicrobial property against Escherichia coli and Bacillus subtilis and were found to be highly hemocompatible in nature. On the basis of the preliminary results, the developed organogels can be used as matrices for the topical drug delivery. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013

Development and Characterization of Sorbitan Monostearate and Sesame Oil-Based Organogels for Topical Delivery of Antimicrobials

“…In general, water-devoid organogels require a high gelator concentration to induce gelation. Shah et al found the minimum sorbitan monostearate concentration to be 20% w/w using olive oil as apolar phase (13). Behera et al used 18% w/w of sorbitan monostearate for preparing sunflower oil-based organogels (37).…”

“…Sorbitan monostearatebased organogels have also been developed for pharmaceutical applications (13,14).…”

Synthesis and characterization of novel dual environment-responsive hydrogels of Hydroxyethyl methacrylate and Methyl cellulose

“…FWHM has been reported to be inversely related to the crystallinity of the formulations. [32] The results suggested that the incorporation of MC into the pHEMA matrix resulted in the increased crystallinity of the HM2. A further increase in the MC Table 2.…”

Core–shell-type organogel–alginate hybrid microparticles: A controlled delivery vehicle

“…The organogels were prepared by heat-cool method as per the reported literature [15]. In short, accurately weighed stearic acid and vegetable oil mixture was heated in a water-bath maintained at 70 ºC for 15 min to form a clear homogenous solution.…”

“…Hemocompatibility of the microparticles was evaluated using goat blood as per the ASTM standard protocol described earlier [15,26]. The cytocompatibility of the microparticles was determined against MG63 osteoblast cells.…”