Development of Okra-Based Antidiabetic Nutraceutical Formulation from Abelmoschus esculentus (L.) Moench (Ex-maradi Variety)

Muhammad, Ismaila; Matazu, I K; Yaradua, Ibrahim; Yau, Salahuddeen; Nasir, A.; Bilbis, Suleman; Abbas, Yahya

doi:10.26538/tjnpr/v2i2.5

Cited by 9 publications

(9 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Oxidative stress is one of the hallmarks of diabetes mellitus. Hence, agents that inhibit oxidative reactions could reduce complications caused by diabetes [20]. This study shows that diabetic control rats fed normal diet significantly elevated (p < 0.05) serum SOD activities and MDA levels compared to diabetic rats fed okrabased diet.…”

Section: Discussionmentioning

confidence: 55%

Effect of Abelmoschus esculentus (okra)-based diet on streptozotocin-induced diabetes mellitus in adult Wistar rats

Uadia¹,

Imagbovomwan²,

Oriakhi³

et al. 2020

Trop. J. Pharm Res

View full text Add to dashboard Cite

Purpose: To evaluate the effects of an okra-based diet on streptozotocin-induced diabetes mellitus in adult Wistar rats and its mechanism of action.Methods: Wistar rats (6) were administered streptozotocin (50 mg/kg ip) after an overnight fast. Upon confirmation of diabetes mellitus, the animals were fed ad libitum for 21 days with formulated okrabased test diet in place of normal diet. The rats treated similarly with streptozotocin and fed ad libitum with the normal diet served as diabetic control while rats fed on normal diet and not treated with streptozotocin served as the negative control. Thereafter, the rats were sacrificed, fasting bloodcollected and analysed for glucose concentration and biochemical parameters. Pancreas was also excised for histopathological studies.Results: There was a significant increase in body weight, HDL-cholesterol (p< 0.05) but significant decrease in blood glucose (p < 0.05), serum total cholesterol, triglyceride, LDL-cholesterol and VLDLcholesterol concentrations in the okra-fed diabetic treated rats when compared to the diabetic control group. Furthermore, superoxide dismutase activity (SOD) was significantly higher in the diabetic control, and reduced significantly when fed with okra-based diet (p < 0.05). Catalase (CAT) activity was significantly (p < 0.05) decreased in diabetic control and treated group, whereas it was significantly (p < 0.05) increased in normal control rats. There was a significant (p < 0.05) decrease in reduced glutathione levels. The significant (p< 0.05) increase in malondialdehyde in the diabetic group was significantly decrease in the diabetic rats fed with okra-diet. Also serum insulin level was significantly (p < 0.05) increased and serum α amylase activity was significantly (p < 0.05) decrease in the diabetic treated rats. Histology results show that there was damage to the β cells of the pancreas in the diabetic control when compared to normal control, but rats fed okra diet was able to regenerate endocrine β cells.Conclusion: Okra-based diet lowers hyperglycaemia as well as regenerate/repair endocrine β-cells and exocrine tissues of the pancreas damage by streptozotocin Keywords: Abelmoschus esculentus, Diabetes mellitus, anti-diabetic, Insulin, α-amylase, Mechanism

show abstract

Section: Discussionmentioning

confidence: 55%

Effect of Abelmoschus esculentus (okra)-based diet on streptozotocin-induced diabetes mellitus in adult Wistar rats

Uadia¹,

Imagbovomwan²,

Oriakhi³

et al. 2020

Trop. J. Pharm Res

View full text Add to dashboard Cite

show abstract

“…Several efforts are being made to improve the well-known hypoglycemic outcomes of okra fruit by formulating different proportions of seeds and peels of Ex-maradi Okra fruit in the ratio of (10:90, 20:80, 30:70, 40:60, 50:50%, and so on), which is subsequently followed by investigating the antidiabetic and antioxidant efficacy of these formulations in vitro. Recent findings have led to the conclusion that seeds and peels at the ratio of 10:90% are the most efficient in exhibiting substantial in vitro antidiabetic and antioxidant efficacy [ 134 , 135 ]. Subsequently, it was recommended that the nutraceutical formulation of peel and Ex-maradi okra seeds in the ratio (10:90) exhibits substantial hypoglycemic and hypolipidemic activity in alloxan models of diabetes (rodents) and was thus appropriate for further improvements for the formulation of okra-based nutraceutical interventions in diabetes mellitus [ 135 ].…”

Section: Formulation and Development Of Okra-based Nutraceuticalsmentioning

confidence: 99%

Okra (Abelmoschus Esculentus) as a Potential Dietary Medicine with Nutraceutical Importance for Sustainable Health Applications

et al. 2021

View full text Add to dashboard Cite

Recently, there has been a paradigm shift from conventional therapies to relatively safer phytotherapies. This divergence is crucial for the management of various chronic diseases. Okra (Abelmoschus esculentus L.) is a popular vegetable crop with good nutritional significance, along with certain therapeutic values, which makes it a potential candidate in the use of a variety of nutraceuticals. Different parts of the okra fruit (mucilage, seed, and pods) contain certain important bioactive components, which confer its medicinal properties. The phytochemicals of okra have been studied for their potential therapeutic activities on various chronic diseases, such as type-2 diabetes, cardiovascular, and digestive diseases, as well as the antifatigue effect, liver detoxification, antibacterial, and chemo-preventive activities. Moreover, okra mucilage has been widely used in medicinal applications such as a plasma replacement or blood volume expanders. Overall, okra is considered to be an easily available, low-cost vegetable crop with various nutritional values and potential health benefits. Despite several reports about its therapeutic benefits and potential nutraceutical significance, there is a dearth of research on the pharmacokinetics and bioavailability of okra, which has hampered its widespread use in the nutraceutical industry. This review summarizes the available literature on the bioactive composition of okra and its potential nutraceutical significance. It will also provide a platform for further research on the pharmacokinetics and bioavailability of okra for its possible commercial production as a therapeutic agent against various chronic diseases.

show abstract

“…Moreover, the current work of Muhammad et al [104] has developed and tested a potential okra-based antidiabetic nutraceutical formulation from Abelmoschus esculentus (L.) Moench (ex-maradi variety): this formulation consists of a 10:90% (seeds:peel) formulation and has shown a reduction effect the rate of glucose adsorption and diffusion and thus can retard increase in postprandial blood glucose level than the other combinations tested in the study (proportions of the powdered seeds and peels samples 80:20%, 70:30%, 60:40%, 50:50%, and vice versa).…”

Section: An Updated Overview Of Potential Beneficial Effects Assocmentioning

confidence: 99%

Abelmoschus esculentus (L.): Bioactive Components’ Beneficial Properties—Focused on Antidiabetic Role—For Sustainable Health Applications

Durazzo¹,

Lucarini²,

Novellino

et al. 2018

Molecules

View full text Add to dashboard Cite

The main features of the okra, Abelmoschus esculentus (L.), are highlighted. The evaluation of interactions between biologically active compounds and other components of the food matrix can be considered as the first action in the investigation of potential benefits of this annual herb. Moreover, updated examples of current and innovative directions in an integrated and multidisciplinary approach are discussed, with particular attention to chemometrics. Among the main effects attributed to okra, its antidiabetic property is the focus. Finally, the use of okra in different fields will be discussed.

show abstract

Development of Okra-Based Antidiabetic Nutraceutical Formulation from Abelmoschus esculentus (L.) Moench (Ex-maradi Variety)

Cited by 9 publications

References 17 publications

Effect of Abelmoschus esculentus (okra)-based diet on streptozotocin-induced diabetes mellitus in adult Wistar rats

Effect of Abelmoschus esculentus (okra)-based diet on streptozotocin-induced diabetes mellitus in adult Wistar rats

Okra (Abelmoschus Esculentus) as a Potential Dietary Medicine with Nutraceutical Importance for Sustainable Health Applications

Abelmoschus esculentus (L.): Bioactive Components’ Beneficial Properties—Focused on Antidiabetic Role—For Sustainable Health Applications

Contact Info

Product

Resources

About