Development of Octyl Methoxy Cinnamates (OMC)/Silicon Dioxide (SiO2) Nanoparticles by Sol-Gel Emulsion Method

Abstract

Although octyl methoxy cinnamates (OMC) is the most used Ultraviolet B (UVB) filter in sunscreen, it has poor light stability in emulsion system. In this study, OMC/SiO2 nanoparticles were prepared via sol-gel emulsion method. Tetraethoxy silane (TEOS) was used as the silica source to encapsulate OMC. Modification of experimental parameters such as stirring speed of condensation reaction and emulsion condition, pH value of acid-catalyzed, surfactant and different percentage of TEOS and OMC, adding of OMC and surfactant to different phase may affect the particle size, and yield and entrapment efficiency in preparation process of OMC/SiO2 nanoparticles. Concluding all the parameter, we found that when condensation reaction and emulsion conditions are at 1000 rpm, pH 1.5, Span 80/Tween 20, TEOS/OMC ratios 1:1, OMC and surfactants added in oil phase, resulting in smaller particle sizes 476.5 nm, higher yield 95.8%, and higher entrapment efficiency 61.09%. Fourier transform infrared (FTIR) analysis demonstrated that OMC/SiO2 nanoparticles were successfully prepared. In vitro release profile supposed that OMC/SiO2 nanoparticles can delay OMC releasing and had 60.83% decreasing of cumulative amount. Therefore, the OMC/SiO2 nanoparticles have the potential to develop as new sunscreen materials in the use for cosmetics field in the future.

Research progress of keratinocyte‐programmed cell death in UV‐induced Skin photodamage

“…The ultraviolet rays that reach the Earth are mainly divided into long‐wave ultraviolet rays (ultraviolet radiation A, UVA, 320 ~ 400 nm) and medium‐wave ultraviolet rays (ultraviolet radiation B, UVB, 290 ~ 320 nm). UVA accounts for 95% of the ultraviolet radiation that reaches the Earth's surface 1 and leads to skin ageing and wrinkling because of cellular DNA damage by reactive oxygen species (ROS) production 2,3 . UVB is a major cause of skin reddening and sunburn through direct DNA damage 3 .…”

Dealing with Skin and Blood-Brain Barriers: The Unconventional Challenges of Mesoporous Silica Nanoparticles

“…Tolbert et al have designed hybrid organic/inorganic silica particles, encapsulating organic sunscreens in silica NPs, in order to reduce their phototoxicity and degradation [59]. Similarly, the octyl methoxycinnamate, one of the most common UVB filters included in sunscreen formulations, when encapsulated in silica scaffold, improve its photostability [47], corroborating the usefulness of silica nanosystems in the cosmetic field.…”

“…Other agents, such as routin, used in cosmetics for UV protection and for their antioxidant properties, have been incorporated in the MSNs cavities in order to improve their photostability and optimize their biological function [47,52].…”

Anti-UV Microgel Based on Interfacial Polymerization to Decrease Skin Irritation of High Permeability UV Absorber Ethylhexyl Methoxycinnamate

“…The sunscreens containing 4-coumaric acid and EHMC showed better UV-shielding effectiveness in 16 lignin models, with a SPF of 19.37. The improvement was attributed to the interaction between the aromatic rings of the lignin models and EHMC through PD-stacked π–π stacking [ 13 ].…”