Development of novel wound care systems based on nanosilver nanohydrogels of polymethacrylic acid with Aloe vera and curcumin

Anjum, Sadiya; Gupta, Amlan; Sharma, Deepika; Gautam, Deepti; Bhan, Surya; Sharma, Anupama; Kapil, Arti; Gupta, Bhuvanesh

doi:10.1016/j.msec.2016.03.069

Cited by 103 publications

(54 citation statements)

References 28 publications

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“…The entrapped Ag NPs and curcumin molecules proved sustained release, which could be exerted in enormous prolonged therapeutic values. 213 Anjum et al 289 reported a composite hydrogel for wound dressing containing nanosilver along with aloe vera and curcumin. It showed better antimicrobial nature, wound healing and infection control compared with the control group.…”

Section: Synergistic Effective Hydrogels Containing Metal Nanoparticlesmentioning

confidence: 99%

“…It showed better antimicrobial nature, wound healing and infection control compared with the control group. 289 Synergistic effective hydrogels containing metal nanoparticles show great antibacterial ability and large antibacterial spectrum. According to distinct antimicrobial pathways, it is impossible to develop antimicrobial resistance.…”

Section: Synergistic Effective Hydrogels Containing Metal Nanoparticlesmentioning

confidence: 99%

See 1 more Smart Citation

Antimicrobial hydrogels: promising materials for medical application

Yang

Han

Chen

et al. 2018

IJN

290

218

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The rapid emergence of antibiotic resistance in pathogenic microbes is becoming an imminent global public health problem. Local application of antibiotics might be a solution. In local application, materials need to act as the drug delivery system. The drug delivery system should be biodegradable and prolonged antibacterial effect should be provided to satisfy clinical demand. Hydrogel is a promising material for local antibacterial application. Hydrogel refers to a kind of biomaterial synthesized by a water-soluble natural polymer or a synthesized polymer, which turns into gel according to the change in different signals such as temperature, ionic strength, pH, ultraviolet exposure etc. Because of its high hydrophilicity, unique three-dimensional network, fine biocompatibility and cell adhesion, hydrogel is one of the suitable biomaterials for drug delivery in antimicrobial areas. In this review, studies from the past 5 years were reviewed, and several types of antimicrobial hydrogels according to different ingredients, different preparations, different antimicrobial mechanisms, different antimicrobial agents they contained and different applications, were summarized. The hydrogels loaded with metal nanoparticles as a potential method to solve antibiotic resistance were highlighted. Finally, future prospects of development and application of antimicrobial hydrogels are suggested.

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Section: Synergistic Effective Hydrogels Containing Metal Nanoparticlesmentioning

confidence: 99%

Section: Synergistic Effective Hydrogels Containing Metal Nanoparticlesmentioning

confidence: 99%

Antimicrobial hydrogels: promising materials for medical application

Yang

Han

Chen

et al. 2018

IJN

290

218

View full text Add to dashboard Cite

show abstract

“…Therefore, the incorporation of aloe vera into alginate hydrogel films can tailor the water absorption and degradation rate, which are important properties for tissue engineering applications, particularly for wound dressing. Recently Anjum et al [140] have developed a two-step process to fabricate a composite material containing nano-silver hydrogels of poly(methacrylic acid), aloe vera, and curcumin. The composite material was evaluated using in vitro antimicrobial and in vivo animal studies.…”

Section: Aloe Vera Based Gels and Filmsmentioning

confidence: 99%

Aloe Vera for Tissue Engineering Applications

Rahman

Carter

Bhattarai

2017

JFB

144

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Aloe vera, also referred as Aloe barbadensis Miller, is a succulent plant widely used for biomedical, pharmaceutical and cosmetic applications. Aloe vera has been used for thousands of years. However, recent significant advances have been made in the development of aloe vera for tissue engineering applications. Aloe vera has received considerable attention in tissue engineering due to its biodegradability, biocompatibility, and low toxicity properties. Aloe vera has been reported to have many biologically active components. The bioactive components of aloe vera have effective antibacterial, anti-inflammatory, antioxidant, and immune-modulatory effects that promote both tissue regeneration and growth. The aloe vera plant, its bioactive components, extraction and processing, and tissue engineering prospects are reviewed in this article. The use of aloe vera as tissue engineering scaffolds, gels, and films is discussed, with a special focus on electrospun nanofibers.

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“…The antiseptic property of Aloe vera is due to presence of six antiseptic agents namely lupeol, salicylic acid, urea nitrogen, cinnamonic acid, phenols and sulphur. These compounds have inhibitory action on fungi, bacteria and viruses, (Zawahry et al, 1973;Qian et al, 2015;Anjum et al, 2016).…”

Section: Antisepticmentioning

confidence: 99%

Recent update on the medicinal properties and use of Aloe vera in the treatment of various ailments

Mahor¹,

Ali²

2016

Biosci. Biotech. Res. Comm

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Aloe vera (Aloe barbadensis) an herb is widely used in Ayurvedic, Homoeopathic and Allopathic streams for its marvelous medicinal properties. This plant is one of the richest natural sources of health for mammals including human beings. The chemistry of the plant has revealed the presence of more than 200 different biologically active substances, which include antimicrobial, antibacterial, antifungal, antiviral, activities of the nonvolatile constituents of the leaf gel. Aloe species are widely distributed in the African and the eastern European continents, and are spread almost throughout the world. The genus Aloe has more than 400 species but few, such as A. vera, Aloe ferox, and Aloe arborescens, are globally used for trade. Many biological properties associated with Aloe species are contributed by inner gel of the leaves. anti diabetic, anti-infl ammatory, peptic ulcers, antitumor, anticancer Properties, activity effects on the Immune System, adverse reactions, Laxative effects, wound healing, antiseptic, vitamins, minerals, enzymes, amino acids, stress, sugars. It is known to help slow down the appearance of wrinkles and actively repair the damaged skin cells that cause the visible signs of aging. Aloe is a powerful detoxifi er, antiseptic and tonic for the nervous system. Aloe vera gel contains a large range of vitamins even vitamin B12, Vitamin A, contains B-Group vitamins, Vitamin C, Vitamin E and folic acid. Aloe vera gel contains important ingredients including 19 of the 20 amino acids needed by the human body and seven of the eight essential ones that just cannot be made. The plant leaves and inner gel contains numerous help it has potential to cure sunburns and minor cuts, and even skin cancer and acts as also acts as extremely powerful laxative. Various parts of the plant have different effects on the body. The present review is an attempt to highlight the proven research related botanical and pharmacological medicinal properties of Aloe vera.

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Development of novel wound care systems based on nanosilver nanohydrogels of polymethacrylic acid with Aloe vera and curcumin

Cited by 103 publications

References 28 publications

Antimicrobial hydrogels: promising materials for medical application

Antimicrobial hydrogels: promising materials for medical application

Aloe Vera for Tissue Engineering Applications

Recent update on the medicinal properties and use of Aloe vera in the treatment of various ailments

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