Development of novel tools for dissection of central versus peripheral dopamine D2-like receptor signaling in dysglycemia
Alessandro Bonifazi,
Michael Ellenberger,
Zachary J. Farino
et al.
Abstract:Dopamine (DA) D2-like receptors in both the central nervous system (CNS) and the periphery are key modulators of metabolism. Moreover, disruption of D2-like receptor signaling is implicated in dysglycemia. Yet, the respective metabolic contributions of CNS versus peripheral D2-like receptors including D2(D2R) and D3(D3R) receptors remain poorly understood. To address this, we developed new pharmacological tools, D2-like receptor agonists with diminished and delayed blood-brain barrier capability, to selectivel… Show more
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