Development of novel surface coating composed of <scp>MDPB</scp> and <scp>MPC</scp> with dual functionality of antibacterial activity and protein repellency

Thongthai, Pasiree; Kitagawa, Haruaki; Kitagawa, Ranna; Hirose, Nanako; Noree, Susita; Iwasaki, Yasuhiko; Imazato, Satoshi

doi:10.1002/jbm.b.34661

Cited by 23 publications

(45 citation statements)

References 28 publications

(42 reference statements)

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“…They suggested that an MPC polymer coating in the oral cavity may suppress oral bacterial adherence [ 95 ]. Recent research has focused on the combined application of MPC and other antimicrobial agents, such as DMAHDM [ 96 ], S-PRG [ 97 ] and MDPB [ 22 ]. The relevant content will be explained in detail in the multi-functional strategy module below.…”

Section: Current Antimicrobial Strategies Of Resin Compositesmentioning

confidence: 99%

Recent Progress in Antimicrobial Strategies for Resin-Based Restoratives

Sun¹,

Zhang²,

Bai³

et al. 2021

Polymers

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Repairing tooth defects with dental resin composites is currently the most commonly used method due to their tooth-colored esthetics and photocuring properties. However, the higher than desirable failure rate and moderate service life are the biggest challenges the composites currently face. Secondary caries is one of the most common reasons leading to repair failure. Therefore, many attempts have been carried out on the development of a new generation of antimicrobial and therapeutic dental polymer composite materials to inhibit dental caries and prolong the lifespan of restorations. These new antimicrobial materials can inhibit the formation of biofilms, reduce acid production from bacteria and the occurrence of secondary caries. These results are encouraging and open the doors to future clinical studies on the therapeutic value of antimicrobial dental resin-based restoratives. However, antimicrobial resins still face challenges such as biocompatibility, drug resistance and uncontrolled release of antimicrobial agents. In the future, we should focus on the development of more efficient, durable and smart antimicrobial dental resins. This article focuses on the most recent 5 years of research, reviews the current antimicrobial strategies of composite resins, and introduces representative antimicrobial agents and their antimicrobial mechanisms.

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Section: Current Antimicrobial Strategies Of Resin Compositesmentioning

confidence: 99%

Recent Progress in Antimicrobial Strategies for Resin-Based Restoratives

Sun¹,

Zhang²,

Bai³

et al. 2021

Polymers

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“…We believe PEP-PC can be used in dental applications. Thongthai et al [ 71 ] synthesized MPC polymers with 12-methacryloyloxydodecylpyridinium bromide (MDPB) and BMA and coated them on the surface of a resin for controlling bacterial growth in the oral environment ( Figure 5(a,b) ). This coating provided a more hydrophilic surface than that coated by MDPB and reduced the adsorption of BSA and salivary protein.…”

Section: Antibiofouling and Antimicrobial Propertiesmentioning

confidence: 99%

“…Scale bars = 30 μm. Reprinted with permission from [ 71 ]. Copyright (2020) Wiley.…”

Section: Antibiofouling and Antimicrobial Propertiesmentioning

confidence: 99%

Controlled biointerfaces with biomimetic phosphorus-containing polymers

Hiranphinyophat

Iwasaki

2021

Science and Technology of Advanced Materials

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Phosphorus is a ubiquitous and one of the most common elements found in living organisms. Almost all molecules containing phosphorus in our body exist as analogs of phosphate salts or phosphoesters. Their functions are versatile and important, being responsible for forming the genetic code, cell membrane, and mineral components of hard tissue. Several materials inspired from these phosphorus-containing biomolecules have been recently developed. These materials have shown unique properties at the biointerface, such as nonfouling ability, blood compatibility, lubricity, mineralization induction capability, and bone affinity.Several unfavorable events occur at the interface of materials and living organisms because most of these materials have not been designed while taking host responses into account. These unfavorable events are directly linked to reducing functions and shorten the usable periods of medical devices.Biomimetic phosphorus-containing polymers can improve the reliability of materials in biological systems. In addition, phosphorus-containing biomimetic polymers are useful not only for improving the biocompatibility of material surfaces but also for adding new functions due to the flexibility in molecular design.In this review, we describe the recent advances in the control of biointerfacial phenomena with phosphorus-containing polymers. We especially focus on zwitterioninc phosphorylcholine polymers and polyphosphoesters.

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“…It was found that the incorporation of DHMAI in resin can improve antimicrobial effectiveness, while the addition of MPC to DHMAI did not provide a better antimicrobial effectiveness and affected the mechanical properties of composites. Thongthai et al [ 73 ] utilized the MPC polymer possessing the function of protein repellency to address the problem, in which the effectiveness of immobilized bactericide was reduced by salivary protein coverage. Both the MDPB and MPC were able to fabricate a novel copolymer, which served as a surface coating on a methacrylate-based dental resin, but the MDPB/MPC copolymer exhibited a more hydrophilic surface than that provided by MDPB, reducing the adsorption of salivary protein.…”

Section: Antimicrobial Propertiesmentioning

confidence: 99%

Application of Antimicrobial Polymers in the Development of Dental Resin Composite

et al. 2020

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Dental resin composites have been widely used in a variety of direct and indirect dental restorations due to their aesthetic properties compared to amalgams and similar metals. Despite the fact that dental resin composites can contribute similar mechanical properties, they are more likely to have microbial accumulations leading to secondary caries. Therefore, the effective and long-lasting antimicrobial properties of dental resin composites are of great significance to their clinical applications. The approaches of ascribing antimicrobial properties to the resin composites may be divided into two types: The filler-type and the resin-type. In this review, the resin-type approaches were highlighted. Focusing on the antimicrobial polymers used in dental resin composites, their chemical structures, mechanical properties, antimicrobial effectiveness, releasing profile, and biocompatibility were included, and challenges, as well as future perspectives, were also discussed.

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Development of novel surface coating composed of MDPB and MPC with dual functionality of antibacterial activity and protein repellency

Cited by 23 publications

References 28 publications

Recent Progress in Antimicrobial Strategies for Resin-Based Restoratives

Recent Progress in Antimicrobial Strategies for Resin-Based Restoratives

Controlled biointerfaces with biomimetic phosphorus-containing polymers

Application of Antimicrobial Polymers in the Development of Dental Resin Composite

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