Development of novel polyglycerol fatty acid ester-based nanoparticles for the dermal delivery of tocopherol acetate

Uchino, Tomonobu; Fujimori, Shun; Hatta, Ichiro; Miyazaki, Yasunori; Kamiya, Daichi; Fujino, Hiyori; Suzuki, Rie; Kirishita, Yukako; Eda, Takashi; Murashima, Kenji; Kagawa, Yoshiyuki

doi:10.1016/j.ijpharm.2020.120004

Cited by 6 publications

(2 citation statements)

References 35 publications

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“…The obtained concentration in the VED (above 60 µg/g) is enough to expect these effects when the concentration data were referenced against reported data for median effective concentration and median inhibition concentration. [12][13][14][15] The morphology of sSP is shown in Fig. 5.…”

Section: Resultsmentioning

confidence: 99%

Development of an Auraptene-Loaded Transdermal Formulation Using Non-ionic Sugar Ester Surfactants

Flores,

Okada,

Arce Jr.

et al. 2024

CHEMICAL & PHARMACEUTICAL BULLETIN

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Auraptene (Aur) is a naturally occurring monoterpene coumarin ether that exhibits numerous therapeutic properties. Its high lipophilicity and low skin penetration, however, limit its potential application for local and transdermal delivery. Biocompatible non-ionic sugar esters (SEs) possess beneficial properties for the development of transdermal formulations in delivering pharmaceutically challenging molecules such as graphene and Aur. In the present study, we conducted a series of experiments to demonstrate the effect of several previously unstudied SEs on the skin permeation and distribution of Aur by preparing gel-and dispersion-type formulations. Skin permeation and deposition experiments were conducted using a Franz diffusion cell with rat skin as the membrane. The dispersion-type formulations prepared using SEs had higher entrapment efficiency, as well as better skin permeation and retention profiles. The dispersion-type formulation containing sucrose palmitate (sSP) exhibited the highest skin permeation over 8 h. Notably, the enhancement effects on Aur concentration in full-thickness skin after the application of the dispersion-type formulation was higher than those of the control formulation. These results indicated that the prepared formulation has potential for use in the transdermal delivery of Aur in pharmaceutical and cosmetic products.

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Section: Resultsmentioning

confidence: 99%

Development of an Auraptene-Loaded Transdermal Formulation Using Non-ionic Sugar Ester Surfactants

Flores,

Okada,

Arce Jr.

et al. 2024

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…In fact, the presence of hair follicles on the skin models adopted for this experiment is not homogeneous, and this may account for the variation in the obtained experimental evidence [ 21 ]. Due to its low solubility, TOCO has been extensively loaded in lipid-based cosmetic and/or dermatological formulations [ 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ]. According to recent literature, ultrasmall PIT SLNs allow a relevant skin permeation, vs. both skin accumulation from the same SLNs and permeation from control suspension.…”

Section: Discussionmentioning

confidence: 99%

Ultrasmall Solid-Lipid Nanoparticles via the Polysorbate Sorbitan Phase-Inversion Temperature Technique: A Promising Vehicle for Antioxidant Delivery into the Skin

Della Sala,

Borzacchiello,

Dianzani

et al. 2023

Pharmaceutics

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Solid lipid nanoparticles promote skin hydration via stratum corneum occlusion, which prevents water loss by evaporation, and via the reinforcement of the skin’s lipid-film barrier, which occurs through the adhesion of the nanoparticles to the stratum corneum. The efficacy of both phenomena correlates with lower nanoparticle size and the increased skin permeation of loaded compounds. The so-called Polysorbate Sorbitan Phase-Inversion Temperature method has, therefore, been optimized in this experimental work, in order to engineer ultrasmall solid-lipid nanoparticles that were then loaded with α-tocopherol, as the anti-age ingredient for cosmetic application. Ultrasmall solid-lipid nanoparticles have been proven to be able to favor the skin absorption of loaded compounds via the aforementioned mechanisms.

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Evaluation of molecular interaction between intercellular lipid organization in human stratum corneum and terpenes using time-resolved synchrotron X-ray diffraction

Uchino,

Hatta,

Nakajo

et al. 2024

Chemistry and Physics of Lipids

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Development of novel polyglycerol fatty acid ester-based nanoparticles for the dermal delivery of tocopherol acetate

Cited by 6 publications

References 35 publications

Development of an Auraptene-Loaded Transdermal Formulation Using Non-ionic Sugar Ester Surfactants

Development of an Auraptene-Loaded Transdermal Formulation Using Non-ionic Sugar Ester Surfactants

Ultrasmall Solid-Lipid Nanoparticles via the Polysorbate Sorbitan Phase-Inversion Temperature Technique: A Promising Vehicle for Antioxidant Delivery into the Skin

Evaluation of molecular interaction between intercellular lipid organization in human stratum corneum and terpenes using time-resolved synchrotron X-ray diffraction

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