Development of novel linear, block, and branched oligoelectrolytes and functionally targeting nanoparticles

Abstract

The objective of the present study is development of novel surface-active block, comb-like, and branched copolymers with peroxide-containing chains, as well as derived functional luminescent and magnetic nanoparticles. The main experimental approaches are based on tailored synthesis of the oligoperoxide surfactants of desired structures and derived coordinating complexes of transitional and rare earth elements. Oligoperoxide-based synthesis of luminescent, magnetic, and other functional nanocomposites with controlled size distribution, functionality, reactivity, and biocompatibility is described. Developed methods provide combining the formation of polymeric, metal, and metal-oxide nanoparticles with irreversible modification of their surface by functional fragments capable of radical and other reactions, including binding of physiologically active substances. Novel nanoparticles were studied by chemical, colloidal-chemical, and rheological methods, X-ray diffraction technique, luminescent spectroscopy, and transmission and scanning electronic microscopy. The availability of ditertiary peroxide fragments on the nanoparticle surface provides a possibility of radical grafting functional polymer chains. The developed functional nanoparticles have been used for phagocytosis measurement, as well as markers of pathological cells, antimicrobial remedies, and nanocarriers for targeted drug delivery.

Novel Peroxide Containing Pegylated Polyampholytic Block Copolymers

“…At the same time the increase of the MP concentration in the initial monomer system leads to the enhancement of its relative content in block-copolymer molecules (Table 1). Taking into account the mechanisms of the initiation by the system PEG-OH-Ce 4+ [16][17][18][19][20] and the termination of growing radicals via interaction with MP molecules [21] the assumed scheme of di-block copolymer synthesis containing the reactive peroxide fragment is proposed (Fig. 3).…”

Genetic transformation of moss Ceratodon purpureus by means of polycationic carriers of DNA

“…riers of crest like shape are rather effective [11]. It is known that association of DNA into a complex with these carriers and their release do not cause changes in the structure of nucleic acid.…”

“…To transform moss C. purpureus, we used new sur face active polycation carriers of linear mono and diblock structure synthesized at the department of organic chemistry of the Lviv Polytechnic National University [11]. Actually, they are linear oligomers DMAEM with hydrophobic final di tert butyl aryl peroxide fragment, and also obtained diblock copoly mers on its basis.…”

Functional micelles formed by branched polymeric surfactants: Synthesis, characteristics, and application as nanoreactors and carriers

“…Three main approaches for synthesis comb-like copolymers were used [20][21][22][23]: 1) direct grafting side polymeric branches to a backbone via polymer analogous transformation; 2) copolymerization of the macromers with conventional functional monomers; 3) "grafting from" via radical polymerization initiated by the multi-site polymeric initiators containing peroxide or azo-side groups disposed along the backbone.…”