Development of novel carboxymethyl cellulose/k-carrageenan blends as an enteric delivery vehicle for probiotic bacteria

Dafe, Alireza; Etemadi, Hossein; Zarredar, Habib; Mahdavinia, Gholam Reza

doi:10.1016/j.ijbiomac.2017.01.016

Cited by 77 publications

(27 citation statements)

References 41 publications

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“…Furthermore, the gel properties of κ-carrageenan have been improved by mixing it with other coating materials, such as vegetable oils, calcium alginate, as well as several gums (e.g., xanthan, gellan, and locust bean gums). These mixtures were used for the successful microencapsulation of probiotic through emulsification [39,69,70,84,183].…”

Section: Anionic Polysaccharidesmentioning

confidence: 99%

“…A study using CMC and chitosan as coating materials for the microencapsulation of L. acidophilus showed the ability of these materials to improve of probiotic viability during its simulated gastrointestinal transit [32]. In another study, blends of CMC and κ-carrageenan were used as coating materials for the microencapsulation of probiotic L. plantarum, and they showed suitability for the production of microcapsules for oral delivery of viable probiotics [84].…”

Section: Anionic Polysaccharidesmentioning

confidence: 99%

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A Brief Review of Edible Coating Materials for the Microencapsulation of Probiotics

et al. 2020

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The consumption of probiotics has been associated with a wide range of health benefits for consumers. Products containing probiotics need to have effective delivery of the microorganisms for their consumption to translate into benefits to the consumer. In the last few years, the microencapsulation of probiotic microorganisms has gained interest as a method to improve the delivery of probiotics in the host as well as extending the shelf life of probiotic-containing products. The microencapsulation of probiotics presents several aspects to be considered, such as the type of probiotic microorganisms, the methods of encapsulation, and the coating materials. The aim of this review is to present an updated overview of the most recent and common coating materials used for the microencapsulation of probiotics, as well as the involved techniques and the results of research studies, providing a useful knowledge basis to identify challenges, opportunities, and future trends around coating materials involved in the probiotic microencapsulation.

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Section: Anionic Polysaccharidesmentioning

confidence: 99%

Section: Anionic Polysaccharidesmentioning

confidence: 99%

A Brief Review of Edible Coating Materials for the Microencapsulation of Probiotics

et al. 2020

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“…Three different hydrogel formulations were prepared by dissolving the corresponding polymeric mixture in distilled water: 2% [w/v] sodium alginate (Acros Organics); 2% sodium alginate/2% starch (Panreac); and 2% sodium carboxymethyl cellulose (Sigma Aldrich)/1% k-carrageenan (Sigma Aldrich). The choice of these proportions was based on the information obtained from hardening studies carried out with different concentrations of hydrogels and on the results previously reported by other authors [8,24].…”

Section: Bead-forming Proceduresmentioning

confidence: 99%

“…Carboxymethyl cellulose (CMC) is the most widely used cellulose ether, employed in many food applications as a viscosity modifier or thickener. Blends of CMC and k-carrageenan (CMC/k-carr) have been studied for probiotic encapsulation with k-carrageenan as a coating material [8,9].…”

Section: Introductionmentioning

confidence: 99%

Exploring encapsulation strategies as a protective mechanism to avoid amensalism in mixed populations of Pseudomonas taetrolens and Lactobacillus casei

García

Ranieri

Rendueles

et al. 2019

Bioprocess Biosyst Eng

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Pseudomonas taetrolens constitutes an efficient platform for the biosynthesis of lactobionic acid, a potentially prebiotic compound. Unfortunately, an amensalistic interaction has been demonstrated between P. taetrolens and probiotic lactic acid bacteria (LAB), characterised by the competitive exclusion of P. taetrolens, hindering the in situ production of fermented dairy products with synbiotic properties. In the present research, encapsulation was explored as a barrier to the diffusion of the antimicrobial metabolites generated by LAB. Mixed fermentations involving P. taetrolens LMG 2336 and Lactobacillus casei CECT 475 were cultivated, entrapping 2 both microorganisms alternately. Alginate, alginate/starch and carboxymethyl cellulose/k-carrageenan were tested as encapsulating agents. The immobilization of L. casei in 2% alginate/2% starch beads was found to be the best strategy, improving the production of lactobionic acid by 182% with respect to co-cultures with free cells. This study proves the potential of LAB encapsulation for the protection of sensitive strains in mixed food fermentations.

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“…The oil-entrapped beads were spherical, translucent and slightly yellowish. It was found that a minimum of 25% w/w rice bran oil was necessary to impart satisfactory buoyancy to the beads [12][13][14] .…”

Section: Fig 8: Proposed Model Of Emulsion-gelation Process By Whichmentioning

confidence: 99%

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2018

IJPSR

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Floating Drug delivery systems are designed to prolong the gastric residence time after oral administration. Ofloxacin is an antibacterial fluoroquinolone, widely prescribed in gastric and duodenal ulcers. It exhibits pH dependent solubility, more soluble in acidic pH and slightly soluble in neutral or alkaline pH. Precipitation of the drug occurs in the intestine, which adversely affects the absorption in the lower sections of the intestine. So there is a need for systems that reside in the stomach over a relatively long period and release the active compound in a sustained manner. The aim of the present study was to develop a delivery system wherein the retention of Ofloxacin could be achieved for increasing local action in the gastric region against Helicobacter pylori, with the development of rice bran oil entrapped zinc pectinate beads containing Ofloxacin. Various formulations of floating beads of Ofloxacin were developed using polymers like Low Methoxy Pectin alone and in combination with rate controlling polymers such as Gellan Gum, Karaya Gum and Xanthan Gum. The beads were prepared by emulsion gelation method. Rice bran oil was used to impart buoyancy to the beads due to its low density. The beads were spherical in nature and beads formulated with a mixture of Low Methoxy Pectin and Gellan Gum showed the highest drug content and drug entrapment. The buoyancy studies on the beads proved that a minimum of 25% w/w of rice bran oil was required to impart satisfactory buoyancy to the beads.

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Development of novel carboxymethyl cellulose/k-carrageenan blends as an enteric delivery vehicle for probiotic bacteria

Cited by 77 publications

References 41 publications

A Brief Review of Edible Coating Materials for the Microencapsulation of Probiotics

A Brief Review of Edible Coating Materials for the Microencapsulation of Probiotics

Exploring encapsulation strategies as a protective mechanism to avoid amensalism in mixed populations of Pseudomonas taetrolens and Lactobacillus casei

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