Development of novel antimicrobial acrylic denture modified with copper nanoparticles

Correa, S.; Matamala, Loreto; González, Juan Pablo; Fuente, Mónica De la; Miranda, Hugo F.; Olivares, Benjamín E.; Maureira, Miguel; Agüero, Amaru; Gómez, Leyla; Lee, Ximena; Urzúa, Madeleine; Covarrubias, Cristian

doi:10.2186/jpr.jpr_d_22_00227

Cited by 6 publications

(2 citation statements)

References 59 publications

(59 reference statements)

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“…Although PMMA has several benefits, it is not considered an ideal DBM. To enhance the physical and mechanical properties of PMMA, several studies have been performed [ 2 , 145 , 146 , 147 , 148 , 149 ].…”

Section: Classification Of Dbmsmentioning

confidence: 99%

Polymeric Denture Base Materials: A Review

Alqutaibi,

Baik,

Almuzaini

et al. 2023

Polymers

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An ideal denture base must have good physical and mechanical properties, biocompatibility, and esthetic properties. Various polymeric materials have been used to construct denture bases. Polymethyl methacrylate (PMMA) is the most used biomaterial for dentures fabrication due to its favorable properties, which include ease of processing and pigmenting, sufficient mechanical properties, economy, and low toxicity. This article aimed to comprehensively review the current knowledge about denture base materials (DBMs) types, properties, modifications, applications, and construction methods. We searched for articles about denture base materials in PubMed, Scopus, and Embase. Journals covering topics including dental materials, prosthodontics, and restorative dentistry were also combed through. Denture base material variations, types, qualities, applications, and fabrication research published in English were considered. Although PMMA has several benefits and gained popularity as a denture base material, it has certain limitations and cannot be classified as an ideal biomaterial for fabricating dental prostheses. Accordingly, several studies have been performed to enhance the physical and mechanical properties of PMMA by chemical modifications and mechanical reinforcement using fibers, nanofillers, and hybrid materials. This review aimed to update the current knowledge about DBMs’ types, properties, applications, and recent developments. There is a need for specific research to improve their biological properties due to patient and dental staff adverse reactions to possibly harmful substances produced during their manufacturing and use.

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Section: Classification Of Dbmsmentioning

confidence: 99%

Polymeric Denture Base Materials: A Review

Alqutaibi,

Baik,

Almuzaini

et al. 2023

Polymers

View full text Add to dashboard Cite

show abstract

“…та гальмували утворення біоплівки залежно від дози [57]. При цьому на прикладі введення різних концентрацій НЧ CuO в ПММА гарячої полімеризації було показано, що вони цитотоксичні лише при застосуванні у високих концентраціях (50 і 500 мкг/мл) і водночас підвищують міцність зразків пластмаси [58].…”

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Application of Antimicrobial Nanoparticles of Metals and Their Oxides in Improving Dental Prostheses

Lugova,

Dobrobolska,

Dobrovolskyi

et al. 2024

Act. Probl. of the Modern Med.

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Many nanoparticles of metals and their oxides, including silver, titanium, zinc, copper, zirconium, have antimicrobial properties. These nanoparticles are a promising strategy for the treatment and prevention of oral cavity infections and can be used in various fields of dentistry. The purpose of the work is to present a literature review on the application of applying antimicrobial nanoparticle of metals and their oxides in orthopedic dentistry, in particular, in the improvement of materials for the prosthetics of dentition defects. Literature sources were searched in the PubMed database. Articles for the years 2013–2023 were selected for their involvement in orthodontic dentistry and for the availability of microbiological test data. Recent trends indicate a shift towards enhancing the composition of fundamental materials used in dental prostheses. To mitigate infectious complications, a modification of the base plastic by incorporating nanoparticles with antimicrobial properties is proposed. Silver nanoparticles are widely utilized to modify denture materials and, when combined with polymers or applied as a surface coating on biomaterials, exhibit antimicrobial properties against oral pathogens, along with an anti-biofilm effect. Zinc oxide nanoparticles, recognized for their biocompatibility and non-toxic nature, possess significant biocidal properties effective against a broad spectrum of bacteria and fungi. They demonstrate the ability to inhibit biofilm formation by oral cavity microorganisms, not only on acrylic prostheses but also on surfaces like glass, polystyrene, and silicone. Titanium oxide nanoparticles contribute to reducing microorganism adhesion on various prosthetic materials, including acrylic resins, ceramic glass, and stainless steel. Zirconium oxide nanoparticles, distinct from other metal oxide counterparts, do not compromise the aesthetics of dentures. Simultaneously, they enhance density and reduce polymethylmethacrylate porosity, thereby decreasing candida adhesion and proliferation in the samples. Copper oxide nanoparticles exhibit dose-dependent inhibition of C. albicans and Streptococcus spp. growth, along with biofilm formation, and show cytotoxic effects only at high concentrations. Thus, there are metal and metal oxide nanoparticles that can improve the antimicrobial properties of prosthetic materials for orthopedic dentistry and thus ensure the prevention of infectious complications when using dental prostheses, but for their clinical use, the gap between experiment and practice has yet to be bridged.

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Anti-fungal recombinant psoriasin effectively inhibits Candida albicans growth on denture base

Lifshits,

Brohnshtein,

Attias

et al. 2024

Preprint

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Oral candidiasis leading to denture stomatitis is a fungal infection resulting from unregulated growth and adhesion mainly of Candida albicans onto acrylic denture base. Once the biofilm is formed, it is immune resistant and mainstay treatments involve toxic chemical antifungal agents or mechanical cleaning techniques, both offer limited efficacy. Consequently, there is an urgent need for more effective and safer therapeutic approaches. While biological modalities are expanding in general medicine, the exploration of protein-based therapeutics in dental medicine remains limited. This research evaluates the inhibitory effect of recombinantly expressed psoriasin on the growth of Candida albicans on polymethyl methacrylate denture bases. Psoriasin, also known as S100-A7, has shown promise in treating microbial skin infections, and its natural presence in saliva makes it a promising candidate for treating oral microbial infections. Our findings indicate that psoriasin exhibits a strong, dose-dependent inhibition of Candida albicans growth. Further, we incubated a polymethyl methacrylate denture base within the psoriasin solution. Notably, immersing the denture base in the solution completely eradicated fungal growth. Our research utilizes natural antifungal proteins within biomedical devices like denture bases, suggesting psoriasin as a safe alternative to chemical antifungals in dental medicine.

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Development of novel antimicrobial acrylic denture modified with copper nanoparticles

Cited by 6 publications

References 59 publications

Polymeric Denture Base Materials: A Review

Polymeric Denture Base Materials: A Review

Application of Antimicrobial Nanoparticles of Metals and Their Oxides in Improving Dental Prostheses

Anti-fungal recombinant psoriasin effectively inhibits Candida albicans growth on denture base

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