Development of nitrogen-doped hydroxyapatite ceramics

Kaneko, Nao; Suzuki, Yusuke; Umeda, Ryo; Namiki, Ryota; Izawa, Chihiro; Ikeda-Fukazawa, Tomoko; Honda, Michiyo; Takei, Takahiro; Watanabe, Tomoaki; Aizawa, Mamoru

doi:10.1080/21870764.2020.1712799

Cited by 9 publications

(6 citation statements)

References 21 publications

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“…Furthermore, the 3D representation of the 2D optical micrographs characteristic of N and Br co-doped HAp thin films deposited on the glass substrate was in good agreement with the 3D representation of the SEM images showing a smooth surface and lack of irregularities. These results were consistent with previous studies conducted by R.A. Ismail and coworkers [48].…”

Section: Resultssupporting

confidence: 94%

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Nitrogen and Bromide Co-Doped Hydroxyapatite Thin Films with Antimicrobial Properties

et al. 2021

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Hydroxyapatite (Ca10(PO4)6(OH)2, HAp), due to its high biocompatibility, is widely used as biomaterial. Doping with various ions of hydroxyapatite is performed to acquire properties as close as possible to the biological apatite present in bones and teeth. In this research the results of a study performed on thin films of hydroxyapatite co-doped with nitrogen and bromine (NBrHAp) are presented for the first time. The NBrHAp suspension was obtained by performing the adapted co-precipitation method using cetyltrimethylammonium bromide (CTAB). The thin layers of NBrHAp were obtained by spin-coating. The stability of the NBrHAp suspension was examined by ultrasound measurements. The thin layers obtained by the spin-coating method were examined by scanning electron microscopy (SEM), optical microscopy (OM), and metallographic microscopy (MM). The presence of nitrogen and bromine were highlighted by energy-dispersive X-ray spectroscopy (EDS) and X-ray photoelectron spectroscopy (XPS) studies. Fourier transform infrared spectroscopy (FTIR) was used to highlight the chemical status of nitrogen and bromine. In addition, the powder obtained from the NBrHAp suspension was analyzed by XRD. Moreover, the in vitro antimicrobial activity of the NBrHAp suspensions and coatings was investigated using the reference microbial strains Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, and Candida albicans ATCC 10231. The results highlighted the successful obtainment of N and Br co-doped hydroxyapatite suspension for the first time by an adapted co-precipitation method. The obtained suspension was used to produce pure NBrHAp composite thin films with superior morphological properties. The NBrHAp suspensions and coatings exhibited in vitro antimicrobial activity against bacterial and fungal strains and revealed their good antimicrobial activity.

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Section: Resultssupporting

confidence: 94%

“…images showing a smooth surface and lack of irregularities. These results were consistent with previous studies conducted by R.A. Ismail and coworkers [48].…”

Section: Resultssupporting

confidence: 94%

Nitrogen and Bromide Co-Doped Hydroxyapatite Thin Films with Antimicrobial Properties

et al. 2021

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“…Research on carbon nanomaterials-HA nanocomposites is extremely expanding. Carbon nanomaterials include graphene sheets, graphene oxide (GO), carbon nanotubes, graphene nanoribbones, and nanodiamonds along with HA are the main phases of these nanocomposites [3][4][5][6][7]. Among the carbon nanomaterials, graphene has received more attention than others because of its unique properties such as good biocompatibility and excellent mechanical properties.…”

Section: Introductionmentioning

confidence: 99%

Investigating the mechanical behavior of hydroxyapatite-reduced graphene oxide nanocomposite under different loading rates

Nosrati

Sarraf-Mamoory

et al. 2020

Nano Ex.

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In this study, the hydroxyapatite (HA)-reduced graphene oxide (rGO) nanocomposite was investigated for its mechanical properties. The nanocomposite used in this study was made in two stages. The HA-rGO powders were first synthesized by hydrogen gas injected hydrothermal method, and then consolidated by spark plasma sintering. HA-rGO nanocomposite was subjected to Vickers indentation experiments with different loading rates. Various analyzes have been used in this study, including x-rays diffraction, field emission scanning electron microscopy, high-resolution transmission electron microscopy, fast fourier transform, and inverse fast fourier transform. The findings of this study showed that the HA in this nanocomposite was reinforced with rGO sheets coated with HA. As the loading rate increased, the slope of the curves in the elastic region was increased, indicating that the elastic modulus was increased. Also, the contact depth at higher loading rates was increased. Plastic deformation was higher at higher loading rates and the hardness had increased. As the loading rate increased from 300 mN to 1 N, the hardness and elastic modulus increased with more slope than when the loading rate changed from 1 N to 2 N. The presence of rGO sheets had partially controlled the HA brittleness.

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“…The aspiration to use Hap for the treatment of damaged organs or bones has prompted researchers to expand research on this biomaterial [1][2][3][4]. Owing to its very special properties like biocompatibility, bioactivity, osteoconductivity, nontoxicity, bone healing function etc., Hap is being used in the field of biomedical research [5][6][7][8][9][10][11][12][13]. It has also found other notable applications in chromatography, biosensors, gas sensor, catalysts, fuel cells, adsorbents, etc.…”

Section: Introductionmentioning

confidence: 99%

Coupled effect of particle size of the source materials and calcination temperature on the direct synthesis of hydroxyapatite

et al. 2021

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We report the effect of controlled particle size (obtained by using 80, 100, 120, 140 and 200 mesh) of the source materials on the synthesis of a well-known biomaterial, hydroxyapatite (Hap). In addition to this, we have also mapped the consequence of applied temperature (700°C, 800°C and 900°C) on the crystallographic properties and phase composition of the obtained Hap. Nevertheless, although with Hap, in each case, β-tricalcium phosphate (β-TCP) was registered as the secondary phase the ANOVA test revealed that the results of the crystallographic parameters are significantly different for the applied sintering temperature 700°C and 800°C ( p < 0.05), while the data obtained for calcination temperature 800°C are not significantly different from that acquired at 900°C ( p > 0.05). Fourier transform infrared spectrophotometer data ensured that, irrespective of mesh size and calcination temperature, the synthesized Hap samples were of carbonated apatite with B-type substitution. Interestingly, for all cases, the % of carbonate content was below the maximum limit (8%) of the CO 3 2 − ion present in bone tissue hydroxyapatite.

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Development of nitrogen-doped hydroxyapatite ceramics

Cited by 9 publications

References 21 publications

Nitrogen and Bromide Co-Doped Hydroxyapatite Thin Films with Antimicrobial Properties

Nitrogen and Bromide Co-Doped Hydroxyapatite Thin Films with Antimicrobial Properties

Investigating the mechanical behavior of hydroxyapatite-reduced graphene oxide nanocomposite under different loading rates

Coupled effect of particle size of the source materials and calcination temperature on the direct synthesis of hydroxyapatite

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