Development of Nitrofuran Derivative: Composition and Technology of Effervescent Tablets With Solid Dispersions

Elagina, A. O.; Belyatskaya, A. V.; Krasnyuk, I. I.; Степанова, О. И.; Fateeva, T. V.; Smolyarchuk, E. A.; Kozin, Sergey V.; Plakhotnaia, O. N.; Rastopchina, O. V.; Rau, Julietta V.

doi:10.19163/2307-9266-2022-10-1-55-68

Cited by 3 publications

(1 citation statement)

References 32 publications

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“…The major limitation with the use and formulation of effervescent is the inability of excipients to prevent moisture absorption. Hence the formulation scientists are focusing on exploiting different techniques such as a direct compression method (7) . The bubble-or gas-generating reaction of the effervescent couple in the granule is most often the result of the reaction of an acidic agent and an alkaline agent.…”

Section: Introductionmentioning

confidence: 99%

Vitamin C and Cranberry Extract Effervescent Tablet Formulation, Characterization, and Evaluation

Gillani¹,

Khalid

Said³

et al. 2023

IJPIHS

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Background: Effervescent floating tablets are used oral dosage form, to enhance the patient compliance, drug bioavailability and to increase the absorption rate. Cranberry (Vaccinium macrocarpon), widely used as a preventive agent against urinary tract infections, also suggested for Type II diabetes, myalgic encephalomyelitis, scurvy, and as a diuretic pill for being rich in nutrients and anti-oxidant properties. Objectives: The aim of the study is to formulate and evaluate the effervescent tablets of Cranberry and Vitamin C. Methodology: As per defined criteria of US FDA, effervescent tablet as per composition is formulated by citric acid and sodium bicarbonate and intended to dissolve in water before administration. Active substance and excipient compatibility studies were done by UV and FTIR, resulted absence of any interaction. Pre-formulation studies including Bulk density, tapped density, angle of repose, Hausner’s ratio, Carr’s index and water content. Results: Formulations were evaluated for weight variation, thickness, hardness, pH of solution, drug dissolution time, content uniformity as defined specification of U.S.P and BP. Stability and storage condition studies were also monitored with average results of 96% drug assay and dissolution. All the results showed excellent formulation of tablet and flow properties of granules. Conclusion: Further studies required to approach targeted and spontaneous release of active as optimized effervescence maybe helpful in delivery of actives and enhancing patient compliance.

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Section: Introductionmentioning

confidence: 99%

Vitamin C and Cranberry Extract Effervescent Tablet Formulation, Characterization, and Evaluation

Gillani¹,

Khalid

Said³

et al. 2023

IJPIHS

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A review on the role of co-processed excipients in tablet formulations

Burande,

Dhakare,

Dodulkar

et al. 2024

Hybrid Advances

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Development of Composition and Technology of Effervescent Tablets with Biologically Active Complex of Black Chokeberry (<i>Aronia melanocarpa</i> (Michx.) Elliott) Fruits

Pivovarova

Abrosimova

Shebitchenko

et al. 2022

Razrabotka i registraciâ lekarstvennyh sredstv

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Introduction. Actual use of plant raw materials in the production of medicines is caused by a variety of bioactive substance complexes in their composition. These drugs have a wide range of therapeutic effects and in this regard, the properties and compositions of various plant materials are currently being actively studied. Aronia melanocarpa (chokeberry) has been the focus of scientific research for many years to identify various healing properties, and in 2015 its fresh and dried fruits are presented as a plant raw material in the State Pharmacopoeia of the Russian Federation, XIV edition. The variety of biologically active substance complexes of Aronia melanocarpa fruit allows its use in different fields (food and pharmaceutical industries). For this reason, the development of the composition and technology of effervescent tablets containing a complex of biologically active substances and possessing the following advantages: rapid release of active ingredients, high rate of BAS assimilation, usability and pleasant flavor are of interest.Aim. The aim of the present study is to develop the composition and technology of effervescent tablets with a biologically active complex from dried Аronia melanocarpa fruits.Materials and methods. Extracts enriched with anthocyanins were obtained from dried chokeberry fruits. As excipients in the technology of effervescent tablets, sodium carbonate, tartaric acid, lactose monohydrate, povidone (Plasdone™ K-29/32), polyethylene glycol 6000 and aspartame were used. Under laboratory conditions, granules (acidic and basic) were obtained by the method of punching wet masses, where extract (granulate 1) and ethyl alcohol 96 % (granulate 2) were used as a moisturizer. Numerical indicators of medicinal plant raw materials, technological properties of granulate and tableting mass, as well as quality indicators of effervescent tablets were determined according to the methods described in the State Pharmacopoeia of the Russian Federation, XIV edition.Results and discussion. Numerical indicators of dry fruits of Aronia melanocarpa (crushing of raw materials and the content of foreign impurities, total ash in plant raw materials and ash insoluble in hydrochloric acid, content of extractives) were determined, and the good quality of the raw materials used in the subsequent stages of drug development was confirmed. An extract enriched with anthocyanins has been developed. The composition and technology of effervescent tablets with separate granulation of acidic and basic components has been developed. Extract and ethyl alcohol 96 % were used as moisturizers, and aspartame was used to improve taste characteristics. A draft specification for the quality indicators of effervescent tablets based on enriched extraction has been proposed.Conclusion. In the course of the research work, the numerical indicators of medicinal plant raw materials were determined and its quality was confirmed, which enabled its use for further extraction. Extraction conditions were chosen, extracts were obtained. Excipients have been selected, the composition and technology of effervescent tablets based on the extracts of Aronia melanocarpa fruits have been developed, a draft specification for effervescent tablets has been proposed in accordance with the requirements of the State Pharmacopoeia of the Russian Federation, XIV edition.

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Development of Nitrofuran Derivative: Composition and Technology of Effervescent Tablets With Solid Dispersions

Cited by 3 publications

References 32 publications

Vitamin C and Cranberry Extract Effervescent Tablet Formulation, Characterization, and Evaluation

Vitamin C and Cranberry Extract Effervescent Tablet Formulation, Characterization, and Evaluation

A review on the role of co-processed excipients in tablet formulations

Development of Composition and Technology of Effervescent Tablets with Biologically Active Complex of Black Chokeberry (<i>Aronia melanocarpa</i> (Michx.) Elliott) Fruits

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