Development of new Ti50Zr25Nb20Cu5–Ag  high-entropy alloys with excellent antibacterial property, osteo-conductivity and biocompatibility in vitro and in vivo

Yu, Bingxiao; Juma, Talante; Wang, Hao; Bao, Xiaotong; Cao, Xiangyu; Wang, Zhiwen; Wang, Rui; Yang, Xin; Ning, Taiguo; Guang-hua, Liang; Cao, Yongping; Zhang, Tao; Guan, Zhi‐Zhong

doi:10.1016/j.jmst.2022.07.064

Cited by 9 publications

(4 citation statements)

References 48 publications

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“…The histological evaluation of the respective muscle at four weeks indicated that the implant did not induce any toxicity or muscle damage, suggesting the biosafety of this HEA [81]. Likewise, Yu et al's model showed very recently that Ti 50 Zr 25 Nb 20 Cu 2.5 Ag 2.5 HEA exhibits enhanced biocompatibility and higher antibacterial properties than the conventional Ti6Al4V alloy, indicating its suitability for the peri-implant tissue regeneration [77].…”

Section: In Vitro Biological Performance Of Heamentioning

confidence: 79%

“…However, a recent paper by Yu et al reports on the potential of the Ti 50 Zr 25 Nb 20 Cu 2.5 Ag 2.5 HEA to induce osteogenic differentiation of MC3T3-E1 preosteoblasts grown in contact with its surface by studying the gene expression and activity of alkaline phosphatase (ALP) known as an early marker of osteoblast differentiation, as well as mRNA levels of bone morphogenetic protein (BMP)-2 as an osteoinductive factor. This study was comparatively performed on the Ti6Al4V alloy, and the results obtained revealed lower intracellular ALP activity and mRNA expression levels of ALP and BMP-2 than those exhibited by Ti 50 Zr 25 Nb 20 Cu 2.5 Ag 2.5 on the 7th day of culture, suggesting its superior bioactivity [77].…”

Section: In Vitro Biological Performance Of Heamentioning

confidence: 87%

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Technological Aspects and Performance of High Entropy Alloys with Potential Application in Dental Restorations and Reducing Implant Failure

Demetrescu,

Nartita,

Andrei

et al. 2023

Applied Sciences

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Amidst the prevalence of aggressive bacterial infections that can impact both oral and systemic health following various dental and implant procedures, the search for alternative, high-performing and biocompatible materials has become a challenging pursuit. The need for such investigations is increasing owing to the fact that toxicological risks of cobalt–chromium (CoCr) alloys used in dentistry have become a part of the EU’s new Medical Devices Regulations establishing that cobalt metal has been classified as carcinogenic, genotoxic and detrimental to reproduction. Within this context, this review proposes high entropy alloys (HEA) as potential alternatives and presents their characteristics and in vitro biological performance when used as a substrate or coating. Anatomical details of the oral cavity in relationship with prosthodontics and implant dentistry support the paper’s motivation and presentation. The review highlights the innovative manufacturing procedures, microstructure and properties of both the bulk and coatings of BioHEA. It evaluates the performance of BioHEAs based on their complete characterization and assesses their suitability for novel applications in dentistry, serving as the primary objective of this manuscript.

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Section: In Vitro Biological Performance Of Heamentioning

confidence: 79%

Section: In Vitro Biological Performance Of Heamentioning

confidence: 87%

Technological Aspects and Performance of High Entropy Alloys with Potential Application in Dental Restorations and Reducing Implant Failure

Demetrescu,

Nartita,

Andrei

et al. 2023

Applied Sciences

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Section: Silver In Metallic Alloysmentioning

confidence: 99%

“…[180] In comparison to Ti6Al4V, Ti 50 Zr 25 Nb 20 Cu 2.5 Ag 2.5 has demonstrated significant inhibition of the growth and proliferation of S. aureus in a rat joint infection model. [181] Ag-containing titanium alloys have been widely explored. Zhang et al [182] observed that the Ti 2 Ag phase formed when the Ti-Ag alloys are sintered gives the Ti-Ag alloys favorable mechanical properties and corrosion resistance.…”

Section: Silver In Metallic Alloysmentioning

confidence: 99%

Silver‐Containing Biomaterials for Biomedical Hard Tissue Implants

Shao

Zhang

Gong

et al. 2023

Adv Healthcare Materials

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Bacterial infection caused by biomaterials is a very serious problem in the clinical treatment of implants. The emergence of antibiotic resistance has prompted other antibacterial agents to replace traditional antibiotics. Silver is rapidly developing as an antibacterial candidate material to inhibit bone infections due to its significant advantages such as high antibacterial timeliness, high antibacterial efficiency, and less susceptibility to bacterial resistance. However, silver has strong cytotoxicity, which can cause inflammatory reactions and oxidative stress, thereby destroying tissue regeneration, making the application of silver‐containing biomaterials extremely challenging. In this paper, the application of silver in biomaterials is reviewed, focusing on the following three issues: 1) how to ensure the excellent antibacterial properties of silver, and not easy to cause bacterial resistance; 2) how to choose the appropriate method to combine silver with biomaterials; 3) how to make silver‐containing biomaterials in hard tissue implants have further research. Following a brief introduction, the discussion focuses on the application of silver‐containing biomaterials, with an emphasis on the effects of silver on the physicochemical properties, structural properties, and biological properties of biomaterials. Finally, the review concludes with the authors’ perspectives on the challenges and future directions of silver in commercialization and in‐depth research.

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Research progress on antibacterial activity of medical titanium alloy implant materials

et al. 2023

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Development of new Ti50Zr25Nb20Cu5–Ag high-entropy alloys with excellent antibacterial property, osteo-conductivity and biocompatibility in vitro and in vivo

Cited by 9 publications

References 48 publications

Technological Aspects and Performance of High Entropy Alloys with Potential Application in Dental Restorations and Reducing Implant Failure

Technological Aspects and Performance of High Entropy Alloys with Potential Application in Dental Restorations and Reducing Implant Failure

Silver‐Containing Biomaterials for Biomedical Hard Tissue Implants

Research progress on antibacterial activity of medical titanium alloy implant materials

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