Development of New Symptoms Following Medical and Surgical Treatment for Duodenal Ulcer

Browning, J.S.; Houseworth, John H.

doi:10.1097/00006842-195307000-00006

Cited by 41 publications

(9 citation statements)

References 7 publications

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“…Studies utilizing vagotomy have clearly demonstrated the importance of constant bidirectional vagal signaling for appropriate brain function including host behavior. In humans, there have been older reports that ablation of the vagus nerve, a facet of gastrectomy formerly used for the treatment of peptic ulcer, resulted in an increase in the incidence of psychiatric-related disorders (222,1604). Moreover, neurogenic bowel dysfunction is quite common in patients with chronic traumatic complete spinal cord injury (1667).…”

Section: The Vagus Nerve and Beyondmentioning

confidence: 99%

The Microbiota-Gut-Brain Axis

Cryan

O’Riordan

Cowan

et al. 2019

Physiological Reviews

2,815

2,066

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The importance of the gut-brain axis in maintaining homeostasis has long been appreciated. However, the past 15 yr have seen the emergence of the microbiota (the trillions of microorganisms within and on our bodies) as one of the key regulators of gut-brain function and has led to the appreciation of the importance of a distinct microbiota-gut-brain axis. This axis is gaining ever more traction in fields investigating the biological and physiological basis of psychiatric, neurodevelopmental, age-related, and neurodegenerative disorders. The microbiota and the brain communicate with each other via various routes including the immune system, tryptophan metabolism, the vagus nerve and the enteric nervous system, involving microbial metabolites such as short-chain fatty acids, branched chain amino acids, and peptidoglycans. Many factors can influence microbiota composition in early life, including infection, mode of birth delivery, use of antibiotic medications, the nature of nutritional provision, environmental stressors, and host genetics. At the other extreme of life, microbial diversity diminishes with aging. Stress, in particular, can significantly impact the microbiota-gut-brain axis at all stages of life. Much recent work has implicated the gut microbiota in many conditions including autism, anxiety, obesity, schizophrenia, Parkinson’s disease, and Alzheimer’s disease. Animal models have been paramount in linking the regulation of fundamental neural processes, such as neurogenesis and myelination, to microbiome activation of microglia. Moreover, translational human studies are ongoing and will greatly enhance the field. Future studies will focus on understanding the mechanisms underlying the microbiota-gut-brain axis and attempt to elucidate microbial-based intervention and therapeutic strategies for neuropsychiatric disorders.

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Section: The Vagus Nerve and Beyondmentioning

confidence: 99%

The Microbiota-Gut-Brain Axis

Cryan

O’Riordan

Cowan

et al. 2019

Physiological Reviews

2,815

2,066

View full text Add to dashboard Cite

show abstract

“…Another argument against operation in the psychiatrically ill patient admits the possibility of a good physical result while claiming that in psychological terms removal of ulcer symptoms deprives these patients of a means of escape (Browning and Houseworth, 1953). They then no longer have the excuse of their dyspepsia to shield them from upsetting situations and therefore they deterior- Nine patients without and one patient with psychiatric symptoms were not seen at 30-month follow up.…”

Section: Results Of First Studymentioning

confidence: 99%

Peptic ulcer surgery: selection for operation by `earning'

Small¹,

Cay²,

Dugard³

et al. 1969

Gut

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“…A study of the so-called ‘cholinergic anti-inflammatory pathway’ proved that the efferent part of the vagus nerve has protective abilities through the inhibition of proinflammatory cytokines [ 54 ]. Interestingly, patients who undergo vagotomy because of ulcers appear to be more susceptible to neuropsychiatric diseases [ 55 , 56 ]. On the other hand, stimulation of the vagus nerve in mice increased neurogenesis in the hippocampus [ 57 ].…”

Section: Gut–brain Axismentioning

confidence: 99%

Helicobacter pylori Infection and Extragastric Diseases—A Focus on the Central Nervous System

Baj

Forma

Flieger

et al. 2021

Cells

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Helicobacter pylori (H. pylori) is most known to cause a wide spectrum of gastrointestinal impairments; however, an increasing number of studies indicates that H. pylori infection might be involved in numerous extragastric diseases such as neurological, dermatological, hematologic, ocular, cardiovascular, metabolic, hepatobiliary, or even allergic diseases. In this review, we focused on the nervous system and aimed to summarize the findings regarding H. pylori infection and its involvement in the induction/progression of neurological disorders. Neurological impairments induced by H. pylori infection are primarily due to impairments in the gut–brain axis (GBA) and to an altered gut microbiota facilitated by H. pylori colonization. Currently, regarding a potential relationship between Helicobacter infection and neurological disorders, most of the studies are mainly focused on H. pylori.

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Development of New Symptoms Following Medical and Surgical Treatment for Duodenal Ulcer

Cited by 41 publications

References 7 publications

The Microbiota-Gut-Brain Axis

The Microbiota-Gut-Brain Axis

Peptic ulcer surgery: selection for operation by `earning'

Helicobacter pylori Infection and Extragastric Diseases—A Focus on the Central Nervous System

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