Development of new magnetic nanoparticles: Oligochitosan obtained by γ-rays and –coated Fe3O4 nanoparticles

Do, Thao Thi; Nguyen, Thi Hiep; Hoang, Dung Van; Tran, Tuong Vi; Nguyễn, Như Gia; Nguyen, Dai Hai

doi:10.1016/j.apsusc.2017.06.115

Cited by 16 publications

(7 citation statements)

References 27 publications

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“…Chemical preservatives have been used for centuries to maintain freshness, improve visual properties, and prolong the shelf life of food. However, some previous studies reported that chemical additives in food cause a variety of adverse health effects, including cancer in humans [1,2,3,4,5,6]. Phosphoric acid, sodium nitrite, sodium benzoate, propyl gallate, aspartame, monosodium glutamate, butylated hydroxytoluene, potassium nitrite, ammonium sulfate, and titanium dioxide are among food preservatives that might be detrimental to human health [7].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Factors Affecting Antimicrobial Activity of Bacteriocin from Lactobacillus plantarum Microencapsulated in Alginate-Gelatin Capsules and Its Application on Pork Meat as a Bio-Preservative

Bạch

Nguyen

et al. 2019

IJERPH

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Antimicrobial compounds from traditional fermented foods have shown activity against a wide range of pathogen and spoilage microorganisms for several years. In this study, a Lactic acid bacteria (LAB), isolated from Vietnamese traditional fermented yogurt (Lactobacillus plantarum SC01), was encapsulated in alginate-gelatin (ALG-GEL) and the effect of incubation temperature, medium pH and surfactants were assessed. The aims of this research were to evaluate antimicrobial activity of bacteriocin produced by L. plantarum SC01. Another aim the research was to study the quality of pork meat treated with its Bacteriocin in 2 h as a bio-preservative at different storage times (0 h, 12 h, 24 h and 48 h) in room temperature, compared to control (treated with salt 40.0%). The antimicrobial activity of L. plantarum SC01 was identified through the inhibition rate of five indicator organisms, including Escherichia coli, Salmonella sp., Staphylococcus aureus, Listeria monocytogenes, and Bacillus subtilis by co-culture method. The results showed that L. plantarum SC01 microencapsulated in ALG-GEL (2.5% alginate and 6.0% gelatin, w/v) and 3.0% bacteria supplied into modified MRS medium (MRSOPTSC01) produced highly active compound inhibited the growth of indicator organisms at a density of 104–108 CFU/mL. Antibacterial compounds were highly active in a treatment at 80 °C; not to be affected by pH; affected by surfactant as Ethylenediaminetetraacetic acid (EDTA), Sodium dodecyl sulfate (SDS), and Tween. Moreover, LAB obtained from this study show the potent Bacteriocin in its usage as a preservative in food.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Factors Affecting Antimicrobial Activity of Bacteriocin from Lactobacillus plantarum Microencapsulated in Alginate-Gelatin Capsules and Its Application on Pork Meat as a Bio-Preservative

Bạch

Nguyen

et al. 2019

IJERPH

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“…The hydrophilic nature of the shell can also prevent the adsorption of protein on the surface of the delivery system through steric repulsion and then escape the capture of RES and extend their fate in the circulatory system [33,34]. More importantly, we observed that the increase in size of SPION@HP is modest, making their size still in the desired range (6–25 nm) in which a MNP could gain its unique superparamagnetic properties [4,30,31].…”

Section: Resultsmentioning

confidence: 99%

“…Nevertheless, the overall size of these systems was remarkably increased after modification with polymers, which is much larger than the usually reported size range (6–25 nm) for MNPs to have a unique superparamagnetic property [4,8]. Besides, even though coating of polymer can increase the stability of SPIONs, the dramatical decrease in saturation magnetization may occur when using nonmagnetic materials for coating SPIONs [4,30,31]. Therefore, the optimization to develop polymer-coated SPIONs that have suitable size, improved pharmacokinetic profile, controlled release behavior, and preserved magnetic characteristics is necessary.…”

Section: Introductionmentioning

confidence: 99%

Functional Magnetic Core-Shell System-Based Iron Oxide Nanoparticle Coated with Biocompatible Copolymer for Anticancer Drug Delivery

et al. 2019

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Polymer coating has drawn increasing attention as a leading strategy to overcome the drawbacks of superparamagnetic iron oxide nanoparticles (SPIONs) in targeted delivery of anticancer drugs. In this study, SPIONs were modified with heparin-Poloxamer (HP) shell to form a SPION@HP core-shell system for anticancer drug delivery. The obtained formulation was characterized by techniques including transmission electron microscopy (TEM), Fourier transform infrared spectra (FT-IR), vibration sample magnetometer (VSM), proton nuclear magnetic resonance (1H-NMR), and powder X-ray diffraction (XRD). Results showed the successful attachment of HP shell on the surface of SPION core and the inability to cause considerable effects to the crystal structure and unique magnetic nature of SPION. The core-shell system maintains the morphological features of SPIONs and the desired size range. Notably, Doxorubicin (DOX), an anticancer drug, was effectively entrapped into the polymeric shell of SPION@HP, showing a loading efficiency of 66.9 ± 2.7% and controlled release up to 120 h without any initial burst effect. Additionally, MTT assay revealed that DOX-loaded SPION@HP exerted great anticancer effect against HeLa cells and could be safely used. These results pave the way for the application of SPION@HP as an effective targeted delivery system for cancer treatment.

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“…It was reported that DDSs having a size of less than 10 nm will be quickly cleared from the circulatory system due to extravasation and those with the size larger than 200 nm tend to be accumulated in the spleen or taken up rapidly by the mononuclear phagocyte system (MPS). By contrast, nanoparticles that range from 10–200 nm in size can be easily entrapped by endosome during endocytosis, thus facilitating the passive targeting and accumulation of nanoparticles to tumors through EPR effect and reducing toxicity to normal cells [26,42,43,44,45]. Moreover, the conjugation of hydrophilic mPEG on PAMAM G3.0 surface also avoids the action of RES and reduce renal clearance [25,46].…”

Section: Resultsmentioning

confidence: 99%

Partial Surface Modification of Low Generation Polyamidoamine Dendrimers: Gaining Insight into their Potential for Improved Carboplatin Delivery

et al. 2019

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Carboplatin (CAR) is a second generation platinum-based compound emerging as one of the most widely used anticancer drugs to treat a variety of tumors. In an attempt to address its dose-limiting toxicity and fast renal clearance, several delivery systems (DDSs) have been developed for CAR. However, unsuitable size range and low loading capacity may limit their potential applications. In this study, PAMAM G3.0 dendrimer was prepared and partially surface modified with methoxypolyethylene glycol (mPEG) for the delivery of CAR. The CAR/PAMAM G3.0@mPEG was successfully obtained with a desirable size range and high entrapment efficiency, improving the limitations of previous CAR-loaded DDSs. Cytocompatibility of PAMAM G3.0@mPEG was also examined, indicating that the system could be safely used. Notably, an in vitro release test and cell viability assays against HeLa, A549, and MCF7 cell lines indicated that CAR/PAMAM G3.0@mPEG could provide a sustained release of CAR while fully retaining its bioactivity to suppress the proliferation of cancer cells. These obtained results provide insights into the potential of PAMAM G3.0@mPEG dendrimer as an efficient delivery system for the delivery of a drug that has strong side effects and fast renal clearance like CAR, which could be a promising approach for cancer treatment.

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Development of new magnetic nanoparticles: Oligochitosan obtained by γ-rays and –coated Fe3O4 nanoparticles

Cited by 16 publications

References 27 publications

Evaluation of Factors Affecting Antimicrobial Activity of Bacteriocin from Lactobacillus plantarum Microencapsulated in Alginate-Gelatin Capsules and Its Application on Pork Meat as a Bio-Preservative

Evaluation of Factors Affecting Antimicrobial Activity of Bacteriocin from Lactobacillus plantarum Microencapsulated in Alginate-Gelatin Capsules and Its Application on Pork Meat as a Bio-Preservative

Functional Magnetic Core-Shell System-Based Iron Oxide Nanoparticle Coated with Biocompatible Copolymer for Anticancer Drug Delivery

Partial Surface Modification of Low Generation Polyamidoamine Dendrimers: Gaining Insight into their Potential for Improved Carboplatin Delivery

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