Development of new chitosan–cellulose multicore microparticles for controlled drug delivery

Remuñán‐López, Carmen; Lorenzo-Lamosa, M.L; Vila-Jato, J. L.; Alonso, Marı́a José

doi:10.1016/s0939-6411(97)00122-7

Cited by 71 publications

(18 citation statements)

References 19 publications

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“…In this work, the in vitro controlled release properties of the smart hydrogels were studied by using fluorescein isothiocyanate-labeled dextran and BSA (or dextran-FITC and BSA-FITC) as model macromolecular hydrophilic drugs. Dextran and BSA labeled or not labeled with FITC have been widely used as models for macromolecular drugs, such as proteins and peptides, in the studies of in vitro release kinetics of drug delivery systems (22)(23)(24)(25). In comparison with HPC hydrogels, the HPN hydrogels can provide the longterm sustained release of macromolecular drugs at body temperature.…”

Section: Introductionmentioning

confidence: 99%

Comb-Shaped Conjugates Comprising Hydroxypropyl Cellulose Backbones and Low-Molecular-Weight Poly(N-isopropylacryamide) Side Chains for Smart Hydrogels: Synthesis, Characterization, and Biomedical Applications

Zhu

Liu

et al. 2010

Bioconjugate Chem.

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Hydroxypropyl cellulose (HPC) possesses a lower critical solution temperature (LCST) above 40 °C, while the poly(N-isopropylacrylamide) (P(NIPAAm)) exhibits a LCST of about 32 °C. Herein, comb-shaped copolymer conjugates of HPC backbones and low-molecular-weight P(NIPAAm) side chains (HPC-g-P(NIPAAm) or HPN) were prepared via atom transfer radical polymerization (ATRP) from the bromoisobutyryl-functionalized HPC biopolymers. By changing the composition ratio of HPC and P(NIPAAm), the LCSTs of HPNs can be adjusted to be lower than the body temperature. The MTT assay from the HEK293 cell line indicated that HPNs possess reduced cytotoxicity. Some of the hydroxyl groups of HPNs were used as cross-linking sites for the preparation of stable HPN hydrogels. In comparison with the HPC hydrogels, the cross-linked HPN hydrogels possess interconnected pore structures and higher swelling ratios. The in vitro release kinetics of fluorescein isothiocyanate-labeled dextran and BSA (or dextran-FITC and BSA-FITC) as model drugs from the hydrogels showed that the HPN hydrogels are suitable for long-term sustained release of macromolecular drugs at body temperature.

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Section: Introductionmentioning

confidence: 99%

Comb-Shaped Conjugates Comprising Hydroxypropyl Cellulose Backbones and Low-Molecular-Weight Poly(N-isopropylacryamide) Side Chains for Smart Hydrogels: Synthesis, Characterization, and Biomedical Applications

Zhu

Liu

et al. 2010

Bioconjugate Chem.

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“…Whereas, lower concentration of EC would cause loose matrix structure of resulted microcapsules [22,23,33]. Because of its good biocompatibility, non-toxicity, and biodegradability, CS is widely used in pharmaceutical field [34]. Owing to its high molecular weight, CS in HAc solution exhibits considerable viscosity even at low concentration.…”

Section: Ec Microcapsules Prepared With Cs/hac As Outer Aqueous Fluidmentioning

confidence: 99%

Microfluidic preparation of monodisperse ethyl cellulose hollow microcapsules with non-toxic solvent

Liu

Yang

et al. 2009

Journal of Colloid and Interface Science

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“…Examples of PECs for controlling drug release include alginate/CS (3,4), CS/carrageenan (5), CS-cellulose multicore microparticles (6), CS-coated pectin (7), CS/poly(acrylic acid) complexes (8), poly(vinyl alcohol)/sodium alginate blend beads (9), and poly(methacrylic acid-g-ethylene glycol) particles (10).…”

Section: Introductionmentioning

confidence: 99%

Chitosan/Polyethylene Glycol Beads Crosslinked with Tripolyphosphate and Glutaraldehyde for Gastrointestinal Drug Delivery

2010

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Abstract. This study reports on the preparation of chitosan (CS)/polyethylene glycol (PEG) hydrogel beads using sodium diclofenac (DFNa) as a model drug. Following the optimization of the polymer to drug ratio, the chitosan beads were modified by ionic crosslinking with sodium tripolyphosphate (TPP). The CS/PEG/DFNa beads obtained from a (w/w/w) ratio of 1/0.5/0.5 with crosslinking in 10% (w/v) TPP at pH 6.0 for 30 min yielded excellent DFNa encapsulation levels with over 90% loading efficiency. The dissolution profile of DFNa from CS/PEG/DFNa beads demonstrated that this formulation was able to maintain a prolonged drug release for approximately 8 h. Among the formulations tested, the CS/PEG/ DFNa (1/0.5/1 (w/w/w)) beads crosslinked with a combination of TPP (10% (w/v) for 30 min) and glutaraldehyde (GD) (5% (w/v)) were able to provide minimal DFNa release in the gastric and duodenal simulated fluids (pH 1.2 and 6.8, respectively) allowing for a principally gradual drug release over 24 h in the intestinal (jejunum and ileum) simulated fluid (pH 7.4). Thus, overall the CS/PEG beads crosslinked with TPP and GD look to be a promising and novel alternative gastrointestinal drug release system.

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Development of new chitosan–cellulose multicore microparticles for controlled drug delivery

Cited by 71 publications

References 19 publications

Comb-Shaped Conjugates Comprising Hydroxypropyl Cellulose Backbones and Low-Molecular-Weight Poly(N-isopropylacryamide) Side Chains for Smart Hydrogels: Synthesis, Characterization, and Biomedical Applications

Comb-Shaped Conjugates Comprising Hydroxypropyl Cellulose Backbones and Low-Molecular-Weight Poly(N-isopropylacryamide) Side Chains for Smart Hydrogels: Synthesis, Characterization, and Biomedical Applications

Microfluidic preparation of monodisperse ethyl cellulose hollow microcapsules with non-toxic solvent

Chitosan/Polyethylene Glycol Beads Crosslinked with Tripolyphosphate and Glutaraldehyde for Gastrointestinal Drug Delivery

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