Development of new 2-piperidinium-4-styrylcoumarin derivatives with large Stokes shifts as potential fluorescent labels for biomolecules

Eustáquio, Raquel; Ramalho, J. P. Prates; Caldeira, Ana Teresa; Pereira, António

doi:10.1039/d2ra00716a

Cited by 1 publication

(1 citation statement)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, it is widely recognized that the inclusion of such substituents, forming donor-π-bridge-acceptor (D-π-A) structures, can facilitate an efficient intramolecular charge transfer (ICT) process. This, in turn, leads to remarkable and varied photophysical properties in coumarin derivatives [10,[27][28][29][30][31][32][33][34]. Several of these coumarin derivatives have been applied in many important areas such as solar cells, organic light-emitting diodes, and fluorescent probes [26,[35][36][37].…”

Section: Introductionmentioning

confidence: 99%

Rational Design of Cost-Effective 4-Styrylcoumarin Fluorescent Derivatives for Biomolecule Labeling

Eustáquio,

Ramalho,

Caldeira

et al. 2023

Molecules

Self Cite

View full text Add to dashboard Cite

Fluorescent labels are key tools in a wide range of modern scientific applications, such as fluorescence microscopy, flow cytometry, histochemistry, direct and indirect immunochemistry, and fluorescence in situ hybridization (FISH). Small fluorescent labels have important practical advantages as they allow maximizing the fluorescence signal by binding multiple fluorophores to a single biomolecule. At present, the most widely used fluorescent labels available present small Stokes shifts and are too costly to be used in routine applications. In this work we present four new coumarin derivatives, as promising and inexpensive fluorescent labels for biomolecules, obtained through a cost-effective, efficient, and straightforward synthetic strategy. Density functional theory and time-dependent density functional theory calculations of the electronic ground and lowest-lying singlet excited states were carried out in order to gain insights into the observed photophysical properties.

show abstract

Section: Introductionmentioning

confidence: 99%

Rational Design of Cost-Effective 4-Styrylcoumarin Fluorescent Derivatives for Biomolecule Labeling

Eustáquio,

Ramalho,

Caldeira

et al. 2023

Molecules

Self Cite

View full text Add to dashboard Cite

show abstract

Development of new 2-piperidinium-4-styrylcoumarin derivatives with large Stokes shifts as potential fluorescent labels for biomolecules

Abstract: New 2-piperidinium-4-styrylcoumarin derivatives, with large Stokes shifts and high fluorescence quantum yields, as potential fluorescent labels for biomolecules.

Cited by 1 publication

References 39 publications

Rational Design of Cost-Effective 4-Styrylcoumarin Fluorescent Derivatives for Biomolecule Labeling

Rational Design of Cost-Effective 4-Styrylcoumarin Fluorescent Derivatives for Biomolecule Labeling

Contact Info

Product

Resources

About