Development of neuropeptide Y (NPY) immunoreactive neurons in the rat occipital cortex: A combined immunohistochemical‐autoradiographic study

Cavanagh, M.E.; Parnavelas, John G.

doi:10.1002/cne.902970408

Cited by 51 publications

(31 citation statements)

References 40 publications

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“…SOM immunoreactivity in the subplate neurons of the human PFC is observed from 22 postovulatory weeks onward, with maximal density of the positive neurons at 32 postovulatory weeks (Kostović et al, 1991). This difference between developmental patterns of NPY and SOM immunoreactivity does not exist in rat visual cortex (Cavanagh and Parnavelas, 1990). In addition, the location of NPY-ir neurons in the subplate of the human PFC appears to be different from the location in cat visual cortex, where more NPY-ir neurons are in deeper parts of the subplate when it is at its relatively thickest (Chun and Shatz, 1989a).…”

Section: Prenatal and Perinatal Developmentmentioning

confidence: 78%

“…Development of NPY-ir neurons in the human associative PFC has not been studied before. However, data on the cortical development of NPY immunoreactivity exist for rodents (Foster and Schultzberg, 1984;Woodhams et al, 1985;Cavanagh and Parnavelas, 1990) and cats (Wahle and Meyer, 1987;Chun and Shatz, 1989a;Hogan and Berman, 1992). These data indicate an early presence, a protracted increase in density of NPY-ir neurons, and a transient expression of these neurons in the lower cortical layers and subplate, with the cat visual cortex being the exception in one study (Hogan and Berman, 1992).…”

Section: Indexing Terms: Subplate Zone; Cortical Plate; Marginal Zonementioning

confidence: 84%

“…However, it is possible that cell death is the fate of a smaller part of the neuronal population in the subplate, whereas the greater part becomes incorporated into the white matter and layer VI of the adult telencephalon Rakic, 1980, 1990;Meyer et al, 1992). In addition, transient expression of neuroactive substances (see, e.g., Berger et al, 1985;Hohmann et al, 1988;Parnavelas and Cavanagh, 1988;Cavanagh and Parnavelas, 1990;Kostović, 1990b) does not necessarily indicate cell death, because chemical transformation of the developing neuron is another possibility. Afferents targeting cortical neurons may induce this chemical transformation and cause subsequent loss of immunoreactivity.…”

Section: Prenatal and Perinatal Developmentmentioning

confidence: 95%

“…Our data indicate the presence of noticeable individual differences from the ages of about 8-10 years onward, when the adult pattern becomes apparent. The NPY-ir neurons in the white matter are likely to be surviving subplate neurons, but definitive proof can be provided by using the 3 H-thymidine-labelling technique, which is applicable only in experimental animals (Chun and Shatz, 1989b;Cavanagh and Parnavelas, 1990).…”

Section: Postnatal Developmentmentioning

confidence: 99%

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Laminar distribution of neuropeptide Y-immunoreactive neurons in human prefrontal cortex during development

et al. 1997

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Neuropeptide Y (NPY) is present in neurons of the adult human cerebral cortex. In view of the reported roles of NPY in the central nervous system in health and during certain disease conditions, we have studied normal development of NPY immunoreactivity (-ir) in the human prefrontal cortex (PFC), Brodmann areas 9 and 46. Twenty-six specimens ranging from the ages of 14 postovulatory weeks to 34 years exhibited patterns that revealed six periods in the development of the laminar distribution and density of NPY-ir neurons. Changes during prenatal and perinatal periods reflect the onset, development, and resolution of the transient fetal telencephalic compartments, including the subplate zone, in which NPY-ir neurons are especially abundant. Before the age of 1 year, the majority of NPY-ir neurons were found in the subplate zone, whereas, after 1 year, the majority were seen in the cortical layers. This is in contrast with the human visual cortex, where the majority of NPY-ir neurons were still located in the white matter. The density of cortical NPY-ir neurons increased in the fifth developmental period (ages 4-7 years), coinciding with the increase of cortical volume and marked progression of cognitive functions. The adult pattern of a relatively low density of cortical NPY-ir neurons was reached in period 6 (from about 8 years), when individual variation also became apparent. Our data point to a protracted maturation of NPY-ir in the human PFC and to different distribution patterns of NPY-ir neurons in different cortical areas.

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Section: Prenatal and Perinatal Developmentmentioning

confidence: 78%

Section: Indexing Terms: Subplate Zone; Cortical Plate; Marginal Zonementioning

confidence: 84%

Section: Prenatal and Perinatal Developmentmentioning

confidence: 95%

Section: Postnatal Developmentmentioning

confidence: 99%

See 2 more Smart Citations

Laminar distribution of neuropeptide Y-immunoreactive neurons in human prefrontal cortex during development

et al. 1997

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“…Interneuron markers have been partially explored in previous birthdating studies (Cavanagh and Parnavelas, 1988, 1989, 1990Xu et al, 2004;Yozu et al, 2004). A recent study (Xu et al, 2006) highlighted species differences between mouse and rat in the molecular expression profiles of cortical interneurons.…”

Section: Molecular Profiles Of the Fate-mapped Cortical Interneuronsmentioning

confidence: 99%

Physiologically Distinct Temporal Cohorts of Cortical Interneurons Arise from TelencephalicOlig2-Expressing Precursors

et al. 2007

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Inhibitory GABAergic interneurons of the mouse neocortex are a highly heterogeneous population of neurons that originate from the ventral telencephalon and migrate tangentially up into the developing cortical plate. The majority of cortical interneurons arise from a transient embryonic structure known as the medial ganglionic eminence (MGE), but how the remarkable diversity is specified in this region is not known. We have taken a genetic fate mapping strategy to elucidate the temporal origins of cortical interneuron subtypes within the MGE. We used an inducible form of Cre under the regulation of Olig2, a basic helix-loop-helix transcription factor highly expressed in neural progenitors of the MGE. We observe that the physiological subtypes of cortical interneurons are, to a large degree, unique to their time point of generation.

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Morphology of neuropeptide Y-immunoreactive neurons and fibers in human prefrontal cortex during prenatal and postnatal development

Uylings

Delalle

1997

J. Comp. Neurol.

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The subplate and marginal zone are prominent transient zones of the developing cerebral wall and contain a variety of neuropeptide Y-immunoreactive (NPY-ir) cells. This study investigates morphological maturation as well as regression and/or transformation of NPY-ir neurons in the transient compartments and the cortical plate of the human frontal cortex. The most prominent NPY-ir neuronal population is that of NPY-ir subplate neurons. They exhibited features of all subplate neuronal types reported in Golgi-impregnated sections, with the exception of the pyramidal type. The NPY-ir subplate neurons were the largest of all NPY-ir neurons, but their size regressed rather sharply between 1 month after birth and 2 years. In the NPY-ir subplate neurons and in the NPY-ir Cajal-Retzius cells of the marginal zone, signs of degeneration were observed between 36 postovulatory weeks and about 9 months after birth. Only a few subpial granular layer cells were NPY positive, and they exhibited degeneration-like features, such as cytoplasmic vacuolization, as early as 23 postovulatory weeks. However, NPY-ir neurons continued to be present in the adult counterparts of the subplate and marginal zone, i.e., gyral white matter and layer I, respectively. Across cortical layers II-VI, NPY-ir neurons had the hallmarks of all aspinous short-axon types, with the exception of the neurogliaform and the chandelier neuronal types. Some signs of degeneration were also observed among a few cortical NPY-ir neurons around birth. Unlike the NPY-ir subplate neurons, the general development of cortical NPY-ir neurons did not show an obvious decline in neuronal size and was similar to the pattern in Golgi-staining.

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Development of neuropeptide Y (NPY) immunoreactive neurons in the rat occipital cortex: A combined immunohistochemical‐autoradiographic study

Cited by 51 publications

References 40 publications

Laminar distribution of neuropeptide Y-immunoreactive neurons in human prefrontal cortex during development

Laminar distribution of neuropeptide Y-immunoreactive neurons in human prefrontal cortex during development

Physiologically Distinct Temporal Cohorts of Cortical Interneurons Arise from TelencephalicOlig2-Expressing Precursors

Morphology of neuropeptide Y-immunoreactive neurons and fibers in human prefrontal cortex during prenatal and postnatal development

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