Although time-averaged shear wave velocity to the depth of 30 m (V s30) is an important indicator of earthquake site effects, it is difficult to obtain. Several proxies have been used either individually or in combination to infer V s30 values during seismic hazard estimation under limited observational conditions. Sichuan Province is an area highly prone to earthquakes. Complex geological structures and lack of drilling sites mean that it is particularly important to establish a suitable approach for the estimation of V s30 values for site classification. This study compared the application of three proxy-based approaches-geology-based, topographic slope-based, and terrain-based-to the estimation of V s30 values in Sichuan Province. The results revealed that the residual between the measured logV s30 values and the estimations derived from the terrain-based approach was smallest, indicating best predictability. Stability analysis of the three approaches also showed that the terrain-based approach performed best. However, its performance in the plain area was poor, that is, the V s30 values were mostly underestimated. This might indicate that the old strata, hard rock, and alluvial deposits formed by Quaternary glacier sediments were not identified appropriately in the plain area, highlighting the need for localized corrections.