Development of National Research and Clinical Agendas for Patient-Reported Outcomes in IR: Proceedings from a Multidisciplinary Consensus Panel

Kwan, Sharon W.; Charalel, Resmi A.; Stover, Angela M.; Baumhauer, Judith F.; Cella, David; Darien, Gwen; Durack, Jeremy C.; Gerson, Jason; Opelka, Frank G.; Patrick, Donald L.; Salem, Riad; Spies, James B.; Wu, Albert W.; White, Sarah B.

doi:10.1016/j.jvir.2017.08.027

Cited by 11 publications

(5 citation statements)

References 33 publications

(38 reference statements)

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“…The outcome shows an enhanced infiltration of macrophages and T cells into electroporated tumor sites. A similar effect was not observed after cryoablation [ 101 ]. Among urological malignancies, the immunomodulatory effect was investigated and confirmed on murine renal tumors [ 102 ].…”

Section: Irementioning

confidence: 64%

Electroporation-Based Treatments in Urology

Szlasa

Saczko

Kulbacka

2020

Cancers

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The observation that an application of a pulsed electric field (PEF) resulted in an increased permeability of the cell membrane has led to the discovery of the phenomenon called electroporation (EP). Depending on the parameters of the electric current and cell features, electroporation can be either reversible or irreversible. The irreversible electroporation (IRE) found its use in urology as a non-thermal ablative method of prostate and renal cancer. As its mechanism is based on the permeabilization of cell membrane phospholipids, IRE (as well as other treatments based on EP) provides selectivity sparing extracellular proteins and matrix. Reversible EP enables the transfer of genes, drugs, and small exogenous proteins. In clinical practice, reversible EP can locally increase the uptake of cytotoxic drugs such as cisplatin and bleomycin. This approach is known as electrochemotherapy (ECT). Few in vivo and in vitro trials of ECT have been performed on urological cancers. EP provides the possibility of transmission of genes across the cell membrane. As the protocols of gene electrotransfer (GET) over the last few years have improved, EP has become a well-known technique for non-viral cell transfection. GET involves DNA transfection directly to the cancer or the host skin and muscle tissue. Among urological cancers, the GET of several plasmids encoding prostate cancer antigens has been investigated in clinical trials. This review brings into discussion the underlying mechanism of EP and an overview of the latest progress and development perspectives of EP-based treatments in urology.

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Section: Irementioning

confidence: 64%

Electroporation-Based Treatments in Urology

Szlasa

Saczko

Kulbacka

2020

Cancers

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“…It is possible for PROMs to be either disease-specific or general. 20 The EuroQol-5D, a generic QoL questionnaire, measures mobility and self-care and makes comparisons easier. 18,19…”

Section: Discussionmentioning

confidence: 99%

Systematic Review of Use of Patient Reported Outcome in Interventional Radiology

Sugih Laksono

2023

JARMHS

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Introduction: At present, the implementation of patient-reported outcomes in interventional radiology is not widespread. However, they are capable of significantly impacting the manner in which we deliver healthcare. Patient-reported outcomes provide an avenue for evaluating the perceived advantages that patients encounter subsequent to a medical procedure. Furthermore, they facilitate a comparison of these results with those of open procedures that are more invasive, as perceived by the patient. The aim: This study review of use of patient reported outcome in interventional radiology. Methods: For this systematic review, publications that were published from 2012 to 2023 were taken into account during the search process. This was achieved through the utilization of numerous online reference sources, such as Pubmed and SagePub. The decision was made to exclude review articles, previously published works, and incomplete works. Result: We obtained 94 articles from Pubmed and 110 from SagePub. The therapies we extracted were 1 article from Pubmed and 3 articles from SagePub. Conclusion: Quality of life and patient perception must be respected as one of the parameters of successful therapy. Previous research shows that PRO can be used with good validity and reliability as a therapeutic outcome parameter in many cases, including interventional radiology.

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“…For diagnostic imaging, it can be difficult to measure an imaging study's impact on a patient. From the interventional perspective, the limited number of PROMs for conditions that interventional radiologists treat and the heterogeneity of how interventional radiologists practice across the United States and globally make it difficult to standardize PROs collection and analysis [6]. In both groups, issues related to the need for administrative support to assist PROs collection and organization have also limited their use in our field [6].…”

Section: Introductionmentioning

confidence: 99%

“…From the interventional perspective, the limited number of PROMs for conditions that interventional radiologists treat and the heterogeneity of how interventional radiologists practice across the United States and globally make it difficult to standardize PROs collection and analysis [6]. In both groups, issues related to the need for administrative support to assist PROs collection and organization have also limited their use in our field [6]. While significant, these barriers to PROs utilization in radiology can be overcome with formal education and the sharing of experiences (both good and bad) by those experienced in outcomes work.…”

Section: Introductionmentioning

confidence: 99%

“…While significant, these barriers to PROs utilization in radiology can be overcome with formal education and the sharing of experiences (both good and bad) by those experienced in outcomes work. Fortunately, there are many educational resources, including dedicated outcomes seminars, courses, journal articles, and consensus panel recommendations, which can provide information and guidance to radiologists interested in patient outcomes [6][7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

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Imaging-based patient-reported outcomes (PROs) database: How we do it

2020

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Patient-reported outcomes (PROs) provide an essential understanding of the impact a condition or treatment has on a patient, while complementing other, more traditional outcomes information like survival and time to symptom resolution. PROs have become increasingly important in medicine with the push toward patient-centered care. The creation of a PROs database within an institution or practice provides a way to collect, understand, and use this kind of patient feedback to inform quality improvement and develop the evidence base for medical decision-making and on a larger scale could potentially help determine national standards of care and treatment guidelines. This paper provides a first-hand account of our experience setting up an imaging-based PROs database at our institution and is organized into steps the reader can follow for creating a PROs database of their own. Given the limited use of PROs within both diagnostic and interventional radiology, we hope our paper stimulates a new interest among radiologists who may have never considered outcomes work in the past.

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Development of National Research and Clinical Agendas for Patient-Reported Outcomes in IR: Proceedings from a Multidisciplinary Consensus Panel

Cited by 11 publications

References 33 publications

Electroporation-Based Treatments in Urology

Electroporation-Based Treatments in Urology

Systematic Review of Use of Patient Reported Outcome in Interventional Radiology

Imaging-based patient-reported outcomes (PROs) database: How we do it

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