Development of nanofibrous scaffolds for vascular tissue engineering

Zhao, Jin; Qiu, Hui; Chen, Denglong; Zhang, Wenxian; Zhang, Da-chun; Li, Min

doi:10.1016/j.ijbiomac.2013.01.027

Cited by 34 publications

(11 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Additionally, good results have been reported for acellular hybrid vessels of PCL, with PU and collagen or spiders' silk and chitosan, in arterial positions in canines and rats, respectively. 77 , 121 …”

Section: Techniques For Manufacturing a Tevgmentioning

confidence: 99%

The Tissue-Engineered Vascular Graft—Past, Present, and Future

Pashneh‐Tala

MacNeil

Claeyssens

2016

Tissue Engineering Part B: Reviews

622

650

View full text Add to dashboard Cite

Cardiovascular disease is the leading cause of death worldwide, with this trend predicted to continue for the foreseeable future. Common disorders are associated with the stenosis or occlusion of blood vessels. The preferred treatment for the long-term revascularization of occluded vessels is surgery utilizing vascular grafts, such as coronary artery bypass grafting and peripheral artery bypass grafting. Currently, autologous vessels such as the saphenous vein and internal thoracic artery represent the gold standard grafts for small-diameter vessels (<6 mm), outperforming synthetic alternatives. However, these vessels are of limited availability, require invasive harvest, and are often unsuitable for use. To address this, the development of a tissue-engineered vascular graft (TEVG) has been rigorously pursued. This article reviews the current state of the art of TEVGs. The various approaches being explored to generate TEVGs are described, including scaffold-based methods (using synthetic and natural polymers), the use of decellularized natural matrices, and tissue self-assembly processes, with the results of various in vivo studies, including clinical trials, highlighted. A discussion of the key areas for further investigation, including graft cell source, mechanical properties, hemodynamics, integration, and assessment in animal models, is then presented.

show abstract

Section: Techniques For Manufacturing a Tevgmentioning

confidence: 99%

The Tissue-Engineered Vascular Graft—Past, Present, and Future

Pashneh‐Tala

MacNeil

Claeyssens

2016

Tissue Engineering Part B: Reviews

622

650

View full text Add to dashboard Cite

show abstract

“…in vivo experiments with composite TEVGs were performed in the last decade demonstrating the feasibility of the hybrid approach. Murine models have been used to evaluate TEVGs composed of nanofibers of PCL blended with spider silk and chitosan (Zhao et al, 2013 ), and the scaffold showed maintenance of the patency for up to 8 weeks. A more recent experiment involved a decellularized rat aortic vessel in which the lumen was coated with heparin.…”

Section: Tissue Engineeringmentioning

confidence: 99%

Current Strategies for the Manufacture of Small Size Tissue Engineering Vascular Grafts

Carrabba

Madeddu

2018

Front. Bioeng. Biotechnol.

171

144

View full text Add to dashboard Cite

Occlusive arterial disease, including coronary heart disease (CHD) and peripheral arterial disease (PAD), is the main cause of death, with an annual mortality incidence predicted to rise to 23.3 million worldwide by 2030. Current revascularization techniques consist of angioplasty, placement of a stent, or surgical bypass grafting. Autologous vessels, such as the saphenous vein and internal thoracic artery, represent the gold standard grafts for small-diameter vessels. However, they require invasive harvesting and are often unavailable. Synthetic vascular grafts represent an alternative to autologous vessels. These grafts have shown satisfactory long-term results for replacement of large- and medium-diameter arteries, such as the carotid or common femoral artery, but have poor patency rates when applied to small-diameter vessels, such as coronary arteries and arteries below the knee. Considering the limitations of current vascular bypass conduits, a tissue-engineered vascular graft (TEVG) with the ability to grow, remodel, and repair in vivo presents a potential solution for the future of vascular surgery. Here, we review the different methods that research groups have been investigating to create TEVGs in the last decades. We focus on the techniques employed in the manufacturing process of the grafts and categorize the approaches as scaffold-based (synthetic, natural, or hybrid) or self-assembled (cell-sheet, microtissue aggregation and bioprinting). Moreover, we highlight the attempts made so far to translate this new strategy from the bench to the bedside.

show abstract

“…The proliferation of Sprague Dawley Rat Aortic Endothelial Cells (SDRAECs) on pNSR32/PCL/G scaffolds was higher than on pure PCL or even pNSR32/PCL after seven days of culture, providing a higher proliferation index (PI) of 26.8% when compared to that of PCL and pNSR32/PCL (17.8% and 21.5%, respectively) [ 77 ]. Similarly, pNSR32/polycaprolactone (PCL)/chitosan (Cs) blend showed PI of 45.79 ± 0.79% and it could also help the seeded SDRAECs cells to release higher concentration of NO within seven days of culture (40 µm/L for PCL/chitosan blend versus 30 µm/L for pure PCL) [ 78 ].…”

Section: Biological Studies Of Fibrous Small-diameter Blood Vesselmentioning

confidence: 99%

Electrospun Fibrous Scaffolds for Small-Diameter Blood Vessels: A Review

et al. 2018

View full text Add to dashboard Cite

Small-diameter blood vessels (SDBVs) are still a challenging task to prepare due to the occurrence of thrombosis formation, intimal hyperplasia, and aneurysmal dilation. Electrospinning technique, as a promising tissue engineering approach, can fabricate polymer fibrous scaffolds that satisfy requirements on the construction of extracellular matrix (ECM) of native blood vessel and promote the adhesion, proliferation, and growth of cells. In this review, we summarize the polymers that are deployed for the fabrication of SDBVs and classify them into three categories, synthetic polymers, natural polymers, and hybrid polymers. Furthermore, the biomechanical properties and the biological activities of the electrospun SBVs including anti-thrombogenic ability and cell response are discussed. Polymer blends seem to be a strategic way to fabricate SDBVs because it combines both suitable biomechanical properties coming from synthetic polymers and favorable sites to cell attachment coming from natural polymers.

show abstract

Development of nanofibrous scaffolds for vascular tissue engineering

Cited by 34 publications

References 36 publications

The Tissue-Engineered Vascular Graft—Past, Present, and Future

The Tissue-Engineered Vascular Graft—Past, Present, and Future

Current Strategies for the Manufacture of Small Size Tissue Engineering Vascular Grafts

Electrospun Fibrous Scaffolds for Small-Diameter Blood Vessels: A Review

Contact Info

Product

Resources

About