Development of nanocomposite scaffolds based on biomineralization of N,O-carboxymethyl chitosan/fucoidan conjugates for bone tissue engineering

Lu, Hsien Tsung; Lu, Tzu Wei; Chen, Chien Ho; Lu, Kun Ying; Mi, Fwu Long

doi:10.1016/j.ijbiomac.2018.08.179

Cited by 54 publications

(37 citation statements)

References 50 publications

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“…No other degradation products are observed. Such chemical structure will provide appropriate chemical conditions for bone-forming hydroxyapatite crystallization and stimulate its nucleation initiation, since polymeric layers will act as an organic template [40,41]. The incorporation of the aspartic acid also proves the increased intensity of free amino groups in the crosslinked polymer (1574 and 1148 cm −1 ), compared to pure chitosan (1593 and 1149 cm −1 ).…”

Section: Ft-ir Analysismentioning

confidence: 97%

“…The composites were prepared by using polymers of known applicability in tissue engineering [36][37][38]. Ready scaffolds with tunable properties were characterized over their physicochemical properties, such as chemical structure, crystallinity, morphology, effect on biomineralization, and biocompatibility with human osteosarcoma (MG-63) cell lines [39][40][41]. Obtained results showed that proposed biomaterials display extraordinary properties and may significantly contribute to bone-tissue-engineering development.…”

Section: Introductionmentioning

confidence: 99%

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3D Hierarchical, Nanostructured Chitosan/PLA/HA Scaffolds Doped with TiO2/Au/Pt NPs with Tunable Properties for Guided Bone Tissue Engineering

et al. 2020

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Bone tissue is the second tissue to be replaced. Annually, over four million surgical treatments are performed. Tissue engineering constitutes an alternative to autologous grafts. Its application requires three-dimensional scaffolds, which mimic human body environment. Bone tissue has a highly organized structure and contains mostly inorganic components. The scaffolds of the latest generation should not only be biocompatible but also promote osteoconduction. Poly (lactic acid) nanofibers are commonly used for this purpose; however, they lack bioactivity and do not provide good cell adhesion. Chitosan is a commonly used biopolymer which positively affects osteoblasts’ behavior. The aim of this article was to prepare novel hybrid 3D scaffolds containing nanohydroxyapatite capable of cell-response stimulation. The matrixes were successfully obtained by PLA electrospinning and microwave-assisted chitosan crosslinking, followed by doping with three types of metallic nanoparticles (Au, Pt, and TiO2). The products and semi-components were characterized over their physicochemical properties, such as chemical structure, crystallinity, and swelling degree. Nanoparticles’ and ready biomaterials’ morphologies were investigated by SEM and TEM methods. Finally, the scaffolds were studied over bioactivity on MG-63 and effect on current-stimulated biomineralization. Obtained results confirmed preparation of tunable biomimicking matrixes which may be used as a promising tool for bone-tissue engineering.

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Section: Ft-ir Analysismentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

3D Hierarchical, Nanostructured Chitosan/PLA/HA Scaffolds Doped with TiO2/Au/Pt NPs with Tunable Properties for Guided Bone Tissue Engineering

et al. 2020

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“…Therefore, when the DS is less than 1, the product is C6-O-carboxymethyl, and the reaction equation of this is shown in Figure 4A. When the DS is greater than or equal to 1, carboxymethyl substitution occurs simultaneously with the C6-OH and C2-NH2 groups to form N, O-carboxymethyl chitosan [61,62], and the reaction equation of this is shown in Figure 4B. The property of carboxymethyl chitosan (CMCS) is related to the DS, where the DS depends on the amount of the carboxylating agent and the molecular weight of chitosan (CSMW).…”

Section: Carboxylated Chitosanmentioning

confidence: 99%

“…Table 2 shows the applications of common chitosan derivatives in bone tissue engineering. Increased pore size and mechanical properties promote osteoblast differentiation [61] Trimethyl chitosan N,N,N-trimethyl chitosan-heparin polyelectrolyte multilayer Bionic periosteum Good cell compatibility and support osteoblast differentiation [142] Hydroxypropyltrimethylammonium chloride chitosan Alginate/HACC/oyster shell powder Preparation bracket Improve mechanical properties and enhance stent surface area [143] CMCS is a commonly used in bone tissue engineering [137][138][139][140][141]. In addition to the applications shown in Table 2, CMCS can also be used to make nanofiber scaffolds [144].…”

Section: Bone Tissue Engineering Materialsmentioning

confidence: 99%

Chitosan Derivatives and Their Application in Biomedicine

Wang

Meng

et al. 2020

IJMS

601

326

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Chitosan is a product of the deacetylation of chitin, which is widely found in nature. Chitosan is insoluble in water and most organic solvents, which seriously limits both its application scope and applicable fields. However, chitosan contains active functional groups that are liable to chemical reactions; thus, chitosan derivatives can be obtained through the chemical modification of chitosan. The modification of chitosan has been an important aspect of chitosan research, showing a better solubility, pH-sensitive targeting, an increased number of delivery systems, etc. This review summarizes the modification of chitosan by acylation, carboxylation, alkylation, and quaternization in order to improve the water solubility, pH sensitivity, and the targeting of chitosan derivatives. The applications of chitosan derivatives in the antibacterial, sustained slowly release, targeting, and delivery system fields are also described. Chitosan derivatives will have a large impact and show potential in biomedicine for the development of drugs in future.

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“…The gel proved effective in regenerating cartilage in a mouse model (H. Park, Woo, & Lee, ). The N , O ‐carboxymethyl chitosan/fucoidan conjugate formed a three‐dimensional hydrogel based on interconnected macropores, for bone tissue engineering (Lu, Lu, Chen, Lu, & Mi, ). Other crosslinking methods for GAGs, such as urea‐crosslinked HA systems (Fallacara et al, ), poly(ethylene glycol) crosslinked systems (Luo, Kirker, & Prestwich, ; Shu, Liu, Palumbo, Luo, & Prestwich, ), tyramine (TA) modified HA and ChS systems (Ni et al, ) were also developed.…”

Section: Polysaccharidesmentioning

confidence: 99%

Carbohydrate‐based nanomaterials for biomedical applications

Gim

Zhu

Seeberger

et al. 2019

WIREs Nanomed Nanobiotechnol

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Carbohydrates are abundant biomolecules, with a strong tendency to form supramolecular networks. A host of carbohydrate-based nanomaterials have been exploited for biomedical applications. These structures are based on simple monoor disaccharides, as well as on complex, polymeric systems. Chemical modifications serve to tune the shapes and properties of these materials. In particular, carbohydrate-based nanoparticles and nanogels were used for drug delivery, imaging, and tissue engineering applications. Due to the reversible nature of the assembly, often based on a combination of hydrogen bonding and hydrophobic interactions, carbohydrate-based materials are valuable substrates for the creations of responsive systems. Herein, we review the current research on carbohydratebased nanomaterials, with a particular focus on carbohydrate assembly. We will discuss how these systems are formed and how their properties are tuned. Particular emphasis will be placed on the use of carbohydrates for biomedical applications.

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Development of nanocomposite scaffolds based on biomineralization of N,O-carboxymethyl chitosan/fucoidan conjugates for bone tissue engineering

Cited by 54 publications

References 50 publications

3D Hierarchical, Nanostructured Chitosan/PLA/HA Scaffolds Doped with TiO2/Au/Pt NPs with Tunable Properties for Guided Bone Tissue Engineering

3D Hierarchical, Nanostructured Chitosan/PLA/HA Scaffolds Doped with TiO2/Au/Pt NPs with Tunable Properties for Guided Bone Tissue Engineering

Chitosan Derivatives and Their Application in Biomedicine

Carbohydrate‐based nanomaterials for biomedical applications

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