Development of Nano in Situ Gels of Bevacizumab for the Treatment of Ocular Angiogenesis: In Vitro Assessment of Anti-Angiogenesis Activity and Molecular Docking Analysis
Abstract:Objective: The present investigation aims to develop nano in situ gels of bevacizumab and evaluate their safety and efficacy.
Methods: Nanoparticles were designed using the desolvation and double emulsion solvent evaporation technique. The hen’s egg test: chorioallantoic membrane (HET-CAM) assay was adopted to evaluate the anti-angiogenesis and irritancy potential of prepared nano in situ gel. Computational docking study carried out using glide module of Schrodinger software.
Results: The FT-IR study showed no… Show more
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