Development of multistage recombinant protein vaccine formulations against toxoplasmosis using a new chitosan and porin based adjuvant system

Parmaksız, Selin; Gül, Aytül; Alak, Sedef Erkunt; Karakavuk, Muhammet; Can, Hüseyin; Gül, Ceren; Karakavuk, Tuğba; López-Macías, Constantino; Puralı, Nuhan; Döşkaya, Mert; Şenel, Sevda

doi:10.1016/j.ijpharm.2022.122199

Cited by 2 publications

(2 citation statements)

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“…It has been known to be used in anti-viral vaccine strategies that allow favorable interaction with the negatively charged virus. Immunotherapeutic effects of chitosan have been proved by inducing the production of cytokines (e.g., TNF-α, IL-1β, IFN-γ, and IL-10) which become a great indicator in the initiation of humoral immunity [ 25 , 26 , 27 ] and cellular immunity through stimulation of IgG antibodies [ 27 ]. Strong responses through both humoral and cellular immunity are crucial in developing a more efficient vaccine therapy.…”

Section: Animal-based Polymersmentioning

confidence: 99%

“…A combined adjuvant system was achieved by encapsulating chitosan and Salmonella Typhi porins in micro (MicroAS) and nanoparticulate (NanoAS) forms to carry rGRA1 and rBAG1 vaccine antigen against T. gondii in Toxoplasmosis disease was presented [ 27 ]. The new formulation resulted in higher cellular and humoral response in the microsystem compared to the nanosystem.…”

Section: Animal-based Polymersmentioning

confidence: 99%

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Natural Polymeric Composites Derived from Animals, Plants, and Microbes for Vaccine Delivery and Adjuvant Applications: A Review

Nordin

Husna

Ahmad

et al. 2023

Gels

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A key element in ensuring successful immunization is the efficient delivery of vaccines. However, poor immunogenicity and adverse inflammatory immunogenic reactions make the establishment of an efficient vaccine delivery method a challenging task. The delivery of vaccines has been performed via a variety of delivery methods, including natural-polymer-based carriers that are relatively biocompatible and have low toxicity. The incorporation of adjuvants or antigens into biomaterial-based immunizations has demonstrated better immune response than formulations that just contain the antigen. This system may enable antigen-mediated immunogenicity and shelter and transport the cargo vaccine or antigen to the appropriate target organ. In this regard, this work reviews the recent applications of natural polymer composites from different sources, such as animals, plants, and microbes, in vaccine delivery systems.

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