Development of multiresidue DLLME and QuEChERS based LC–MS/MS method for determination of selected neonicotinoid insecticides in honey liqueur

Jovanov, Pavle; Guzsvány, Valéria; Franko, Mladen; Lazić, Sanja; Sakač, Marijana; Milovanović, Ivan; Nedeljković, Nataša

doi:10.1016/j.foodres.2013.10.031

Cited by 87 publications

(49 citation statements)

References 43 publications

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“…LLE was modified by using acidic extraction solvent mixture to avoid the co extraction of antibacterial sulfonamides with pesticides from honey {Gómez-Pérez, 2012 #11}. Certain solvent miniaturized LLE techniques like single drop micro-extraction (SDME), dispersive liquid liquid microextraction (DLLME) (Jovanov, Guzsvány et al 2014), air-assisted liquid-liquid micro-extraction (AALLME) (Farajzadeh, Mogaddam et al 2014), hollow fiber protected liquid phase micro-extraction (HF-LPME) (Yamini, Faraji et al 2015) have been developed and are used frequently to enhance the efficiency and reduce the organic waste generation. Tette et al, 2016 reviewed these techniques in detail {Tette, 2016 #8}.…”

Section: Solvent Extraction/liquid Liquid Extraction (Lle)mentioning

confidence: 99%

Review on Extraction Procedures and Chromatographic Techniques for Analysis of Multiple Pesticides Residues in Honey

Nazir¹

2017

IJNF

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Global consumption rate of honey increased due to its high nutritional and therapeutic values. It is under great experimentation nowa-days. Consumers of the honey products are at stake due to presence of pesticide residues which are hazardous to health. Honey is a complex matrix and pesticides are present in sub-ppb levels, so reliable analytical method for identification and quantification of multiple pesticides is required to ensure the food safety for the consumers in compliance with the EC and Codex Alimentarius regulations. In this review, different sample preparation and detection techniques used globally are discussed especially focusing on honey matrix components-pesticides interference. Future perspectives for minimization of these matrix interferences will also be presented.

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Section: Solvent Extraction/liquid Liquid Extraction (Lle)mentioning

confidence: 99%

Review on Extraction Procedures and Chromatographic Techniques for Analysis of Multiple Pesticides Residues in Honey

Nazir¹

2017

IJNF

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“…To our best knowledge, no rapid method of analysis of up to 132 insecticides belonging to 29 chemical classes in honey samples, using QuEChERS/LC-MS/MS has been described in the literature. Works available in the literature describe methods that make it possible to determine individual groups of insecticides: benzoylurea (Wang et al 2016), neonicotinoids (Gbylik-Sikorska et al 2015;Jovanov et al 2013Jovanov et al , 2014, organochlorines (Zacharis et al 2012), pyrethroids (Li et al 2013), organophosphorus (Naggar et al 2015;Blasco et al 2004), or several groups of insecticides, but never so many. For instance, Paradis et al (2014) reported the simultaneous determination of 22 insecticides of three chemical classes in honey.…”

Section: Introductionmentioning

confidence: 99%

Liquid Chromatographic MS/MS Analysis of a Large Group of Insecticides in Honey by Modified QuEChERS

2018

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The analytical tool for analysis of pesticide residues in honey must still be improved. Therefore, a sensitive, selective, rapid, and reliable analytical method for the analysis of pesticide residue belonging to 29 different classes at very low concentration levels was developed. Over 130 insecticides were extracted from the honey matrix using different amounts of sample, concentrations of the extraction solvent, and cleanup sorbents. Acceptable extraction recoveries accounting for matrix effect were obtained using the cleanup sorbent combination chitosan/aluminum oxide/C8 (200/200/200 mg) and 1% FA in ACN. Determinations were made by liquid chromatography-tandem mass spectrometry (LC-MS/MS). For most compounds, the recoveries range from 70 to 120%, with relative standard deviations < 20%. Linear correlation coefficients (r2) were higher than 0.99 at concentration levels of 0.001-0.100 mg kg−1. A positive matrix effect was observed for up to 95% of organophosphates and 43% of pyrethroids and a negative effect for 37% of neonicotinoids. This work showed that the presented method is convenient and reliable for quick monitoring of insecticides in honey samples.

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“…Nevertheless, their wide use in or on agricultural products might be resulted in the occurrence of residues of these chemicals and their metabolites in raw as well as processed food commodities, water and soil [1]. Alcoholic beverages which are usually prepared from various agricultural products and are considered as a part of human diet [2] could also be directly or indirectly contaminated by these pesticides and subsequently, could affect the health of consumers [3][4][5][6][7][8][9]. To monitor and control the health of consumers, legislative authorities and monitoring organizations of different countries, have set maximum residue limits (MRLs) of pesticide residues in various raw and processed foods, including alcoholic beverages [9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

“…HPLC-DAD [9] was reported for determination of pesticide residues in Ethiopian honey wine, locally called Tej, which is one of the national known home brewed Ethiopian alcoholic beverages and it is prepared from fermented honey and special kind of hops called Gesho (Rhamnus prinoides) [2,9,21,22]. LC-MS/MS [6] was also reported for analysis of pesticide residues in honey liqueur.…”

Section: Introductionmentioning

confidence: 99%

“…However, SPME is expensive, uses fragile and easily broken fibres, has limited lifetime and sometimes sample carry-over could be a problem [23]. Other sample preparation methods such as supported liquid membrane (SLM) [9], microporous membrane liquid-liquid extraction (MMLLE) [13,14], hollow-fibre liquid phase microextraction (HF-LPME) [4], ultrasound-vortex-assisted dispersive liquid-liquid microextraction (USVA-DLLME) [16], dispersive liquidliquid microextraction (DLLME) [6] and quick, easy, cheap, effective, rugged and safe (QuEChERS) [6] as well as dispersive solid-phase extraction (d-SPE) [17] have also been reported for analysis of pesticide multiresidues in alcoholic beverages. Though, these procedures are relatively simple, rapid, cheap and attractive alternative for sample preparation, they are still demanding special equipment, reagents and/or toxic organic solvents.…”

Section: Introductionmentioning

confidence: 99%

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Salting-out Assisted Liquid-Liquid Extraction for the Determination of Multiresidue Pesticides in Alcoholic Beverages by High Performance Liquid Chromatography

Bedassa¹

2017

SJAC

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Abstract:A salting-out assisted liquid-liquid extraction (SALLE) method followed by high-performance liquid chromatography with ultraviolet-visible detector (HPLC-UV/Vis) has been proposed for determination of five multiclass pesticides residues including, atrazine, ametryn, terbutryn, carbaryl and chlorothalonil from various alcoholic beverages: beer, wine and Ethiopian honey wine (Tej). Experimental parameters influencing the extraction efficiency of the method such as the type and concentration of salt, volume of acetonitrile (the extraction solvent) and pH of the sample were assayed and the optimum conditions were established. Under the optimum experimental conditions, matrix-matched calibration curves were constructed using beer sample as the representative matrix and good linearity over wide concentration ranges were obtained with coefficient of determination (r 2 ) of 0.997 or better. The limits of detection (LOD) and quantification (LOQ) of the method, which were determined as 3 and 10 times a signal-to-noise ratio (S/N), were in the ranges of 1.3-3.9 and 4.5-12.8 µg L -1 , respectively. Precisions studied in terms of repeatability and intermediate precision (with-in lab reproducibility) at two concentration levels have demonstrated acceptable %RSD values, which were less than 10% in both cases. The applicability of the method was also investigated by analyzing various alcoholic beverages and demonstrated satisfactory recoveries in the ranges of 71-104% with their corresponding %RSDs less than 10% in all cases. The results of the study revealed that the developed SALLE method is selective and efficient sample preparation procedure prior to quantitative analysis of the target analytes by HPLC-UV/Vis.

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Development of multiresidue DLLME and QuEChERS based LC–MS/MS method for determination of selected neonicotinoid insecticides in honey liqueur

Cited by 87 publications

References 43 publications

Review on Extraction Procedures and Chromatographic Techniques for Analysis of Multiple Pesticides Residues in Honey

Review on Extraction Procedures and Chromatographic Techniques for Analysis of Multiple Pesticides Residues in Honey

Liquid Chromatographic MS/MS Analysis of a Large Group of Insecticides in Honey by Modified QuEChERS

Salting-out Assisted Liquid-Liquid Extraction for the Determination of Multiresidue Pesticides in Alcoholic Beverages by High Performance Liquid Chromatography

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