Development of multiple W/O/W emulsions as dermal carrier system for oligonucleotides: Effect of additives on emulsion stability

Schmidts, Thomas; Dobler, Dorota; Schlupp, Peggy; Nissing, C.; Garn, Holger; Runkel, Frank

doi:10.1016/j.ijpharm.2010.07.037

Cited by 65 publications

(35 citation statements)

References 31 publications

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“…Este fato ocorre com frequência onde a camada de óleo é fina. Outras substâncias que não eletrólitos, como proteínas, açúcares e fármacos podem também exercer este efeito (AKHTAR et al, 2010;SCHMIDTS et al, 2010;WHITEHILL, 1982). Quando a camada de óleo rompe, a fase aquosa interna em gotícula desaparece instantaneamente, seguido pela mistura da fase aquosa interna com o meio aquoso externo e permanecendo no sistema um simples glóbulo de óleo WHITEHILL, 1982).…”

Section: Presença De Eletrólitosunclassified

“…Os tipos mais comuns são água-em-óleo-em-água (A1/O/A2) ou óleo-em-água-em-óleo (O1/A/O2). (PEREIRA; GARCIA-ROJAS, 2015; KUMAR; KUMAR; MAHADEVAN KUMAR, 2012;AKHTAR et al, 2010;SCHMIDTS et al, 2010;MORAIS, 2008;WHATELEY, 1997).…”

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“…(AGRAWAL; KULKARNI; SHARMA, 2015; PEREIRA; GARCIA-ROJAS, 2015;SCHMIDT et al, 2015;AMID;MIRHOSSEINI, 2014;KUMAR;KUMAR;MAHADEVAN KUMAR, 2012;AKHTAR et al, 2010;SCHMIDTS et al, 2010;SCHMIDTS et al, 2009;MORAIS, 2008;CARLOTTI et al, 2005;WHATELEY, 1997;WHATELEY, 1995;OMOTOSHO, 1990;WHITEHILL, 1982). Devido à complexidade das emulsões múltiplas criou-se um sistema de nomenclatura para caracterizar as fases constituintes do sistema.…”

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Controle Da Estabilidade De Emulsões Multiplas

Nunes

Lazinski

Martins

et al. 2017

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Caracterizadas por serem um sistema carreador complexo contendo duas emulsões distintas que coexistem simultaneamente, as emulsões múltiplas apresentam muitas vantagens e aplicações, contudo manter a sua estabilidade apresenta-se ainda como um grande desafio. Foi realizada uma revisão da literatura existente além de uma análise sobre os principais fatores que interferem no controle da estabilidade da emulsão múltipla. Dentre os fatores destaca-se a presença de eletrólitos, a concentração do componente ativo osmótico, a influência dos aditivos estabilizantes, a natureza da fase oleosa, a propriedade dos filmes interfaciais e a relação de volume entre as fases, assim como o método de preparo. A observação desses fatores pode propiciar a elaboração e o uso das emulsões múltiplas de maneira proveitosa e propiciar a sua maior aplicabilidade em produtos farmacêuticos.

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Section: Presença De Eletrólitosunclassified

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Controle Da Estabilidade De Emulsões Multiplas

Nunes

Lazinski

Martins

et al. 2017

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“…The influence of electrolytes such as NaCl, MgSO 4 and other additives such as sugars and proteins was investigated in several studies due to osmotic pressure effect on emulsion stability [97][98][99][100]. Increase in osmotic active agent concentration increased the osmotic pressure of internal droplets and have provided enhanced stability.…”

mentioning

confidence: 99%

“…In addition they provide elasticity to interfacial film and prevent droplet coalescence [101][102][103]. Another way to increase stability is increasing external phase viscosity by using thickeners [97,[104][105][106].…”

mentioning

confidence: 99%

Synthesis and characterization of multi‐hollow opaque polymer pigments

Asmaoğlu

Gündüz

Mavış

et al. 2016

J of Applied Polymer Sci

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Therapeutic DNAzymes: From Structure Design to Clinical Applications

et al. 2023

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Therapeutic DNAzymes have unceasingly intrigued the scientific community owing to their prosperous gene regulation capability. The efficacy of DNAzymes against many types of diseases has been extensively studied for over two decades. However, the high expectations for DNAzymes are still not translated to the clinic because of their low effectiveness in vivo. Over the last five years, several aspects have been considered to optimize DNAzyme‐integrated therapeutics, including structural stability, mechanism exploration, cell internalization rate, cofactor activation, and off‐target effects. Hence, this review first discusses the early monotherapy and structural design of DNAzymes. Subsequently, the latest modes of action are reviewed, followed by an elaboration on structural stabilization strategies considering the catalytic core and substrate‐binding arms. DNAzyme‐based synergistic therapy is then examined, highlighting responsive carrier construction, synergistic effects, the latest discovered advanced functions, and off‐target concerns. Beyond this, key clinical advances in DNAzyme‐based therapy are elucidated by showcasing clinical progress. Finally, future trends and development challenges for DNAzyme‐powered therapeutics in the coming years are discussed in detail.

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Development of multiple W/O/W emulsions as dermal carrier system for oligonucleotides: Effect of additives on emulsion stability

Cited by 65 publications

References 31 publications

Controle Da Estabilidade De Emulsões Multiplas

Controle Da Estabilidade De Emulsões Multiplas

Synthesis and characterization of multi‐hollow opaque polymer pigments

Therapeutic DNAzymes: From Structure Design to Clinical Applications

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