Development of multilayered artificial urethra graft for urethroplasty
Povilas Barasa,
Egidijus Simoliunas,
Aivaras Grybas
et al.
Abstract:To enhance the treatment of patients' urethral defects, such as strictures and hypospadias, we investigated the potential of using artificial urethral tissue. Our study aimed to generate this tissue and assess its effectiveness in a rabbit model. Two types of bioprinted grafts, based on methacrylated gelatin‐silk fibroin (GelMA‐SF) hydrogels, were produced: acellular, as well as loaded with autologous rabbit stem cells. Rabbit adipose stem cells (RASC) were differentiated toward smooth muscle in the GelMA‐SF h… Show more
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