Development of multi-epitope vaccine constructs for non-small cell lung cancer (NSCLC) against USA human leukocyte antigen background: an immunoinformatic approach toward future vaccine designing

Batool, Sana; Bin-T-Abid, Duaa; Batool, Hina; Shahid, Saleem Ullah; Saleem, M.; Khan, Azmat Ullah; Hamid, Arslan; Mahmood, Malik Siddique; Ashraf, Naeem Mahmood

doi:10.1080/14712598.2021.1981285

Cited by 4 publications

(4 citation statements)

References 55 publications

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“…Wang et al observed that TXNDC5 was upregulated in prostate cancer cells after prolonged androgen deprivation therapy (ADT) due to ADT-induced hypoxia upregulating TXNDC5 expression through androgen receptor (AR) protein signaling, thereby their interaction, stability and transcriptional activity. This mechanism further regulates TXNDC5 expression through HIF-1a and miR-200b-dependent pathways (129). The above results suggest that TXNDC5 may play a role as a hypoxia-induced stress survival factor in tumor cells, contributing to tumor cell growth and proliferation under hypoxic conditions.…”

Section: Hypoxia Induces High Expression Of Txndc5mentioning

confidence: 77%

“…found that TXNDC5 was significantly expressed in tumor tissues, including invasive ductal carcinoma of the breast, squamous cell carcinoma of the cervix, squamous cell carcinoma of the esophagus, papillary plasmacytoma of the ovary, and prostate cancer ( 13 ). It was reported that TXNDC5 was also found to have procarcinogenic effects in tissues of several cancers, including prostate cancer (PCa) ( 129 ), colorectal cancer (CRC) ( 130 ) ( 127 ), lung cancer (LCA) ( 131 ), non-small cell lung cancer (NSCLC) ( 132 ), ovarian cancer (OC), gastric cancer (GC) ( 133 , 134 ), cervical cancer (CC) ( 12 ), esophageal squamous cell carcinoma (ESCC) ( 135 ), and hepatocellular carcinoma (HCC) ( 136 ). In samples from patients with LCA, TXNDC5 protein expression was upregulated in more than 60% of NSCLC tissues ( 137 ).…”

Section: Txndc5 and Tumor Tissuesmentioning

confidence: 99%

“…Regarding hepatocellular carcinoma tissue, TXNDC5 expression is increased in poorly differentiated hepatocellular carcinomas but not in highly differentiated tumors. In Pca, TXNDC5 was significantly overexpressed in androgen-intrinsic prostate cancer and desmoplasticresistant prostate cancer (129). In ESCC, Wang et al found that TXNDC5 showed highly expression, indicating that ESCC with high TXNDC5 expression had a poor prognosis (135).…”

Section: Txndc5 and Tumor Tissues 61 Txndc5 Is Highly Expressed In A ...mentioning

confidence: 99%

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The role and mechanism of TXNDC5 in disease progression

Jiao,

Zhang,

Song

et al. 2024

Front. Immunol.

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Thioredoxin domain containing protein-5 (TXNDC5), also known as endothelial protein-disulfide isomerase (Endo-PDI), is confined to the endoplasmic reticulum through the structural endoplasmic reticulum retention signal (KDEL), is a member of the PDI protein family and is highly expressed in the hypoxic state. TXNDC5 can regulate the rate of disulfide bond formation, isomerization and degradation of target proteins through its function as a protein disulfide isomerase (PDI), thereby altering protein conformation, activity and improving protein stability. Several studies have shown that there is a significant correlation between TXNDC5 gene polymorphisms and genetic susceptibility to inflammatory diseases such as rheumatoid, fibrosis and tumors. In this paper, we detail the expression characteristics of TXNDC5 in a variety of diseases, summarize the mechanisms by which TXNDC5 promotes malignant disease progression, and summarize potential therapeutic strategies to target TXNDC5 for disease treatment.

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Section: Hypoxia Induces High Expression Of Txndc5mentioning

confidence: 77%

Section: Txndc5 and Tumor Tissuesmentioning

confidence: 99%

Section: Txndc5 and Tumor Tissues 61 Txndc5 Is Highly Expressed In A ...mentioning

confidence: 99%

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The role and mechanism of TXNDC5 in disease progression

Jiao,

Zhang,

Song

et al. 2024

Front. Immunol.

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“…Additionally, TGFβ1 stimulation can upregulate TXNDC5 via ER stress/ATF6-dependent transcriptional control in lung fibroblasts, leading to excessive activation, proliferation, and ECM production [88,93]. Finally, TXNDC5 is a potential tumor-specific antigen for developing mRNA vaccines and an approach in designing a multi-epitope vaccine targeting TXNDC5 can potentially contribute to NSCLC [87,94]. These studies suggest that targeting TXNDC5 could be a powerful novel approach to ameliorate pulmonary fibrosis, respiratory dysfunction, and lung cancer treatment [86,88,91].…”

Section: Txndc5 and Lung Cancermentioning

confidence: 99%

Thioredoxin Domain Containing 5 (TXNDC5): Friend or Foe?

Bidooki,

Navarro,

Fernandes

et al. 2024

CIMB

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This review focuses on the thioredoxin domain containing 5 (TXNDC5), also known as endoplasmic reticulum protein 46 (ERp46), a member of the protein disulfide isomerase (PDI) family with a dual role in multiple diseases. TXNDC5 is highly expressed in endothelial cells, fibroblasts, pancreatic β-cells, liver cells, and hypoxic tissues, such as cancer endothelial cells and atherosclerotic plaques. TXNDC5 plays a crucial role in regulating cell proliferation, apoptosis, migration, and antioxidative stress. Its potential significance in cancer warrants further investigation, given the altered and highly adaptable metabolism of tumor cells. It has been reported that both high and low levels of TXNDC5 expression are associated with multiple diseases, such as arthritis, cancer, diabetes, brain diseases, and infections, as well as worse prognoses. TXNDC5 has been attributed to both oncogenic and tumor-suppressive features. It has been concluded that in cancer, TXNDC5 acts as a foe and responds to metabolic and cellular stress signals to promote the survival of tumor cells against apoptosis. Conversely, in normal cells, TXNDC5 acts as a friend to safeguard cells against oxidative and endoplasmic reticulum stress. Therefore, TXNDC5 could serve as a viable biomarker or even a potential pharmacological target.

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