Development of mucous membrane pemphigoid with antibodies to the β3 subunit of laminin 332 and bronchiolitis obliterans in a patient with chronic graft-versus-host disease

Non‐paraneoplastic autoimmune subepidermal bullous disease associated with fatal bronchiolitis obliterans

“…Although both BP180 and laminin‐332 are expressed on bronchial epithelial cells, association of BO with these autoantibodies was rarely documented except for cases of paraneoplastic pemphigus. Recently, however, a case of chronic graft‐versus‐host disease associated with anti‐laminin‐332‐type mucous membrane pemphigoid and BO was reported . Further studies are needed to determine the role of anti‐laminin‐332 autoantibodies in the development of BO.…”

Anti‐laminin‐332‐type mucous membrane pemphigoid in a patient with adult T‐cell leukemia/lymphoma and graft‐versus‐host disease

“…1,2 Our review of the published work found no case of antilaminin-332-type MMP associated with ATLL.Patients with autoimmune bullous diseases and GVHD have been reported. [3][4][5] Most patients presented with bullous pemphigoid, and four had anti-laminin-332-type MMP; three of four had the b3 subunit and one had c2. 3,4 Our patient reacted with both a3 and b3 subunits.…”

“…[3][4][5] Most patients presented with bullous pemphigoid, and four had anti-laminin-332-type MMP; three of four had the b3 subunit and one had c2. 3,4 Our patient reacted with both a3 and b3 subunits. However, characteristic clinical features for autoantibodies to different subunits of laminin-332 are still unclear.…”

“…4 The previous MMP developed 6 months to 8 years after transplantation. [3][4][5] Hofmann et al 5 detected circulating basement membrane zone (BMZ) antibodies in 24% of GVHD patients. They suggested that damage of keratinocytes, the subsequent release of antigens by GVHD, and reduced self-tolerance induce the…”