Development of Mucoadhesive Buccal Films of Glipizide

Abstract

For improving bioavailability in controlled release fashion and to circumvent the hepatic first pass effect of glipizide mucoadhesive buccal films of glipizide were prepared by solvent casting technique. Buccal films were prepared using hydroxy propylmethylcellulose, sodium carboxymethylcellulose, carbopol-934P and Eudragit RL-100. Films were evaluated for their weight, thickness, surface pH, swelling index, in vitro residence time, folding endurance, in vitro release, ex vivo permeation studies and drug content uniformity. The films exhibited controlled release over more than 6 h. From the study it was concluded that the films containing 5 mg glipizide in 4.9 % w/v hydroxy propylmethylcellulose and 1.5 % w/v sodium carboxymethylcellulose exhibited satisfactory swelling, an optimum residence time and promising drug release thus proved to be potential candidate for the development of buccal films for therapeutic use.

Formulation and Bioavailability of Novel Mucoadhesive Buccal Films for Candesartan Cilexetil in Rats

“…The drug entrapment mechanisms were also reflected on the thickness and drug content of the prepared film due to its entrapment in the polymer architecture in minute drug crystals or as drug crystals attached to the surface [ 21 , 22 ]. In each case, this led to increasing the thickness of the prepared film comparing to the placebo.…”

“…The weight uniformity of the cut square-shaped sections of the same film was determined gravimetrically, according to Semalty et al [ 21 ]. The weight of 6 samples from each film was determined using a digital balance.…”

Optimization of hydroxypropyl methylcellulose and sodium carboxymethyl cellulose in buccal film salbutamol sulphate

“…The HPMC polymer, when used singly, results in the characteristics of a rigid and slightly brittle film that required the addition of SCMC to increase film flexibility. The film preparations using folding power HPMC polymers increased with the addition of CMC Na [18] . The folding resistance also showed because that the differences in polymer composition and PG plasticizers used in the preparation can produce good film strength and elasticity [17] .…”

“…Films with CMC Na expand and form a layer of gel that opens on the surface of the film. The polymer molecule that is loosely bound to the film is easily eroded, allowing increased drug release [18] . The optimum formula composition consisted of 11.346 mg HPMC and 13.654 mg CMC Na, the dominant component of CMC Na caused the drug release to occur faster.…”

“…The spectra produced by each sample, then compared to see whether there was interaction on the tested formula. If it does not show a significant band shift in the wavelength of salbutamol sulphate, there was no functional group interaction that can affect the therapeutic effect of salbutamol sulphate [18] .…”