Development of more potent anti-microbial drugs from extracts of five medicinal plants resistant to S. aureus in human fluids: an ex vivo and in vivo analysis

Assiri, Rasha; Alharbi, Nada Abdullah; Alsaeed, Thamir Saad; Abdulmonem, Waleed Al; Hershan, Almonther; Alghamdi, Rana A.; Aljohani, Abdullah S.M.; Alkhorayef, Nada; Almatroudi, Ahmad; Allemailem, Khaled S.; Alkhalil, Samia S.; AL-surhanee, Ameena A.; Alghamdi, Mohammed A.; Alkhudhairy, Basal Sulaiman M.; Almohaimeed, Hailah M.

doi:10.1007/s12210-023-01135-7

Cited by 1 publication

(1 citation statement)

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“…These S. aureus methanol extracts have an IC50 of 0.250 to 4.30 mg/ml. Their findings point to the presence of potential antibacterial compounds against S. aureus in a variety of medicinal plants, which may help researchers create more robust treatments for infections caused by the multidrug-resistant bacterium (Assiri et al 2023 ).…”

Section: Antimicrobial Activitymentioning

confidence: 99%

Therapeutic potential of Lawsonia inermis Linn: a comprehensive overview

Batiha,

Teibo,

Shaheen

et al. 2023

Naunyn-Schmiedeberg's Arch Pharmacol

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Lawsonia inermis Linn, commonly known as henna, is a member of the Lythraceae family and has been found to contain a variety of compounds with both industrial and medicinal applications in its stem, bark, roots, flowers, and seeds. This report provides a comprehensive review of the bioactive components, pharmacological activities, pharmacokinetics, and pharmacological side effects of Lawsonia inermis. Relevant materials were gathered from Google Scholar, PubMed, Scopus, and Web of Science and reviewed for important properties and updates about the plant. Lawsonia inermis contains a variety of bioactive compounds, including flavonoids, coumarins, triterpenoids, steroids, xanthones, polyphenols, fatty acids, alkaloids, quinones, tannins, leucocyandin, epicatechin, catechin, and quercetin. The plant is been traditionally used to treat numerous conditions, including ulcers, bronchitis, lumbago, hemicrania, leukoderma, scabies, boils, ophthalmic disorders, hair loss, and jaundice. It has also been found to possess a range of pharmacological activities, including antioxidant, anti-inflammatory, analgesic, antiparasitic, hepatoprotective, antifungal, antitumor, wound healing, and hypoglycemic effects. The potential of Lawsonia inermis for various biological applications is promising, and further studies are needed to fully explore its therapeutic benefits for various diseases of public health. Concern advances in drug development could enable the characterization of various bioactive constituents and facilitate their development and application for the benefit of humanity.

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Section: Antimicrobial Activitymentioning

confidence: 99%