Development of methodology for identification the nature of the polyphenolic extracts by FTIR associated with multivariate analysis

Grasel, Fábio dos Santos; Ferrão, Marco Flôres; Wolf, Carlos Rodolfo

doi:10.1016/j.saa.2015.08.020

Cited by 173 publications

(81 citation statements)

References 55 publications

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“…As shown in Figure 3, the EA spectrum showed its characteristic peaks as described previously. 41,42 A small sharp peak at 3,580 cm…”

Section: Characterization Of the Prepared Npsmentioning

confidence: 99%

Enhanced anticancer activity and oral bioavailability of ellagic acid through encapsulation in biodegradable polymeric nanoparticles

Mady¹,

Shaker²

2017

IJN

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Despite the fact that various studies have investigated the clinical relevance of ellagic acid (EA) as a naturally existing bioactive substance in cancer therapy, little has been reported regarding the efficient strategy for improving its oral bioavailability. In this study, we report the formulation of EA-loaded nanoparticles (EA-NPs) to find a way to enhance its bioactivity as well as bioavailability after oral administration. Poly(ε-caprolactone) (PCL) was selected as the biodegradable polymer for the formulation of EA-NPs through the emulsion–diffusion–evaporation technique. The obtained NPs have been characterized by measuring particle size, zeta potential, Fourier transform infrared, differential scanning calorimetry, and X-ray diffraction. The entrapment efficiency and the release profile of EA was also determined. In vitro cellular uptake and cytotoxicity of the obtained NPs were evaluated using Caco-2 and HCT-116 cell lines, respectively. Moreover, in vivo study has been performed to measure the oral bioavailability of EA-NPs compared to free EA, using New Zealand white rabbits. NPs with distinct shape were obtained with high entrapment and loading efficiencies. Diffusion-driven release profile of EA from the prepared NPs was determined. EA-NP-treated HCT-116 cells showed relatively lower cell viability compared to free EA-treated cells. Fluorometric imaging revealed the cellular uptake and efficient localization of EA-NPs in the nuclear region of Caco-2 cells. In vivo testing revealed that the oral administration of EA-NPs produced a 3.6 times increase in the area under the curve compared to that of EA. From these results, it can be concluded that incorporation of EA into PCL as NPs enhances its oral bioavailability and activity.

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“…As shown in Figure 3, the EA spectrum showed its characteristic peaks as described previously. 41,42 A small sharp peak at 3,580 cm…”

Section: Characterization Of the Prepared Npsmentioning

confidence: 99%

Enhanced anticancer activity and oral bioavailability of ellagic acid through encapsulation in biodegradable polymeric nanoparticles

Mady¹,

Shaker²

2017

IJN

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“…The PC3 separates the tara, myrobalan, and quebracho (positive scores) from the black wattle, chestnut, and valonea (negative scores). 16 …”

Section: Resultsmentioning

confidence: 99%

“…The use of multivariate analysis enables a faster and precise identification methodology based on statistical methods that simultaneously analyze multiple measurements on each individual or object under investigation. [16][17][18][19] Recently, a method was developed using Fourier transform infrared spectroscopy (FTIR) associated with multivariate analysis to identify commercial tannins. 16 Through both principal component analysis (PCA) and hierarchical cluster analysis (HCA), a well-defined Vol.…”

Section: Introductionmentioning

confidence: 99%

“…In another work, a methodology was developed to directly determine the tannin content in Acacia mearnsii bark using near infrared spectroscopy (NIRS) and multivariate calibration methods. 16 The results of the prediction were compared to those obtained through the reference methodology (NBR 11131), 25 showing values for the root mean square error of prediction (RMSEP) between 2.11 and 2.42% for dried and milled bark samples, and 2.31 and 2.54% for in natura samples. The methodology proposed in this work presents an analytical frequency of 10 determinations per hour (including sample preparation procedures), which is significantly higher than the reference methodology (20 hours for each determination).…”

Section: Introductionmentioning

confidence: 99%

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Principal Component Analysis of Commercial Tannin Extracts Using Digital Images on Mobile Devices

Grasel¹,

Ferrão²,

Helfer³

et al. 2016

Journal of the Brazilian Chemical Society

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Tannins from trees are an abundant renewable resource. The use of tannins is safe for the environment and human health, making it possible to develop environmentally friendly products, such as adhesives, flocculant agents for water treatment, flame retardant foams and anticorrosives. In this study, a methodology was developed for the identification of six commercial tannin extracts (chestnut, valonea, tara, myrobalan, quebracho and black wattle) using digital images on mobile devices. The identification of the extracts was based on principal component analysis using the PhotoMetrix ® mobile application. In the evaluation of the principal components, it was possible to define the separation between the six classes of extracts by color evaluation, according to the extract origin. In the analysis of PC1 × PC2, black wattle was very close to quebracho and chestnut was close to valonea; these extracts are chemically similar. The methodology developed for the analysis of tannin extracts obeys the principles of green chemistry requiring no reagents, and is fast, non-destructive and inexpensive.

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“…Las señales C-H aromáticas en el plano se ubicaron en 1122 y 1032 cm -1 para TQ y a 1138 y 1097 cm -1 para TT mientras que las bandas que corresponden C-H aromático fuera del plano se encontraron alrededor de 830 cm -1 para ambos taninos. La banda ubicada a 1709 cm -1 es el resultado del estiramiento C=O característico de los esteres presentes en los taninos hidrolizables, especialmente los derivados del ácido gálico, la cual nos permite distinguir taninos hidrolizables como TT de taninos condensados como TQ, ya que estos últimos, en condiciones naturales, no contienen carbonilo [11].…”

Section: Caracterización De Los "Tanatos" De Quebracho Y De Taraunclassified

Síntesis y caracterización de “tanatos” de lantano como inhibidores de la corrosión

et al. 2018

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RESUMENLos taninos son polifenoles sintetizados por las plantas. Se encuentran en la madera del Quebracho (Schinopsis balansae), los frutos de la Tara (Caesalpinia spinosa), etc. Han sido incorporados en la industria de la pintura como agentes "antifouling" y como inhibidores de la corrosión en soluciones ácidas. Por otra parte, las soluciones de lantano han presentado un efecto inhibidor muy satisfactorio sobre probetas de acero SAE 1010. El objetivo del presente trabajo fue el de obtener dos tipos de "tanato" de lantano de baja solubilidad, a fin de que puedan ser incorporados como inhibidores de la corrosión en recubrimientos protectores temporarios, que protegen el metal durante su traslado y almacenamiento y, eventualmente, en pinturas anticorrosivas. En este trabajo se presenta la obtención de los "tanatos", su caracterización y ensayos electroquímicos en solución de NaCl. Se prevé que si estos ensayos son satisfactorios, los "tanatos" puedan ser incorporados en protectores temporarios. Se obtuvieron 2 "tanatos", empleando taninos de tara y de quebracho comerciales y solución de La(NO 3 ) 3 x 6H 2 O 0,1 M. Los pigmentos se caracterizaron mediante espectrometría infrarroja con transformada de Fourier (FTIR) y su solubilidad fue determinada mediante una técnica colorimétrica utilizando el reactivo de Folin-Denis, mientras que el La +3 soluble se determinó por una técnica gravimétrica con oxalato. La acción protectora de los "tanatos" sintetizados, frente a la corrosión del acero SAE 1010 fue evaluada mediante curvas de polarización y medidas de potencial de corrosión en solución de NaCl. La película protectora formada sobre el acero inmerso en la solución fue observada mediante microscopía electrónica de barrido (MEB) y caracterizada mediante espectroscopía de dispersión de rayos X (EDS). Ambos "tanatos" desplazaron el potencial de corrosión del acero hacia valores más positivos y la resistencia a la polarización resultó uno o dos órdenes de magnitud mayor, con respecto al blanco (solución sin inhibidor) y a soluciones que contenían el tanino comercial correspondiente en diferentes concentraciones. Por otro lado, las determinaciones de la solubilidad de los pigmentos hacen preveer que no serán lixiviados de los recubrimientos prematuramente y que podrán ejercer su acción protectora durante un tiempo adecuado. Palabras clave: taninos, lantano, medidas electroquímicas, corrosión. ABSTRACTTannins are polyphenols synthesized by plants. They are found in Quebracho (Schinopsis Balansae) wood, Tara (Caesalpinia spinosa) fruits, etc. They have been incorporated in the coating industry as "antifouling" agents and as corrosion inhibitors in acidic solutions. Moreover, lanthanum solutions have a great inhibitory effect over SAE 1010 steel corrosion. The aim of this study was to obtain two types of lanthanum "tannate" with low solubility, so they can be incorporated as corrosion inhibitors in temporary protective coatings, those that protect the metal during transportation and storage. Eventually, they could also be emp...

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Development of methodology for identification the nature of the polyphenolic extracts by FTIR associated with multivariate analysis

Cited by 173 publications

References 55 publications

Enhanced anticancer activity and oral bioavailability of ellagic acid through encapsulation in biodegradable polymeric nanoparticles

Enhanced anticancer activity and oral bioavailability of ellagic acid through encapsulation in biodegradable polymeric nanoparticles

Principal Component Analysis of Commercial Tannin Extracts Using Digital Images on Mobile Devices

Síntesis y caracterización de “tanatos” de lantano como inhibidores de la corrosión

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