Development of medication regimen complexity index: Japanese version and application in elderly patients

Masumoto, Shoichi; Momo, Kenji; Matsushita, Aya; Suzuki, Kosuke; Shimamura, Hiroshi; Sasaki, Takeshi; Hamano, Jun

doi:10.1007/s11096-020-01185-z

Cited by 5 publications

(6 citation statements)

References 22 publications

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“…It is also difficult to determine the actual level of adherence to medication. In the future, it will be necessary to use tools that enable comprehensive assessments of polypharmacy to determine both the number of medications and whether the patient is truly polyphasic [30]. Fourth, alcohol intake was only interviewed as "yes" or "no," so it is not known how much alcohol is consumed.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Various Factors Associated With Opioid Dose Escalation in Patients With Cancer Pain

Sakamoto¹,

Koyama²

2022

Cureus

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IntroductionPain is one of the most important symptoms in terms of prevalence and a major cause of distress in patients with cancer. Therefore, this study aimed to analyze and identify the factors that influence the worsening of pain in patients with cancer necessitating opioid dose escalation. MethodsThe study was conducted in a single center. This study is a retrospective cohort study of 390 adult cancer patients. The primary endpoint was dose escalation for strong opioids. Adjusted odds ratios (aORs) and their 95% confidence intervals (CIs) were calculated using a logistic regression model to evaluate the relationships of factors with opioid dose escalation for cancer pain. ResultsPolypharmacy was associated with opioid dose escalation (aOR = 2.54, 95% CI = 1.486-4.370, p = 0.001). Conversely, alcohol consumption was associated with a reduced need for dose escalation (aOR = 0.60, 95% CI = 0.376-0.985, p = 0.043). ConclusionThe results of this study indicate that moderate alcohol consumption does not reduce the efficacy of opioids in patients with cancer pain. Meanwhile, patients receiving polypharmacy may be able to more rapidly alleviate their pain via early opioid dose modification.

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Section: Discussionmentioning

confidence: 99%

Analysis of Various Factors Associated With Opioid Dose Escalation in Patients With Cancer Pain

Sakamoto¹,

Koyama²

2022

Cureus

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“…MRCI was translated into Japanese in the previous study and was confirmed its validity and reliability. 21 MRCI‐J comprises three sections: section A, dosage forms; section B, dosage frequency; section C, additional instructions, which generate a continuous score, with a higher score indicating more complex medication regimen, with no upper limit. PIMs were defined in this study using the Screening Tool for Older Persons' appropriate Prescriptions for Japanese (STOPP‐J).…”

Section: Methodsmentioning

confidence: 99%

“…Data collection was conducted from October 1, 2019, to April 30, 2020. The primary outcome measure was evaluated by comparing changes in medication regimen complexity assessed using MRCI-Japanese version (MRCI-J) 21 before and 3 months after home care initiation. MRCI was translated into Japanese in the previous study and was confirmed its validity and reliability.…”

Section: Variablesmentioning

confidence: 99%

Evaluation of changes in prescription among Japanese elderly patients before and after transition to home care

Masumoto

Yamakawa

Hamada

et al. 2021

J of Gen and Family Med

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“…These factors include the number of medications prescribed, the pharmaceutical forms, schedule management by the patients and/or caregivers, dose regulation, and additional instructions given by the health-care provider [9]. The aforementioned factors can be calculated through the medication regimen complexity index (MRCI) [8], a scale that was validated in Turkish [9], Spanish [10], German [11], Portuguese [12], Korean [13] and Japanese [14].…”

Section: Introductionmentioning

confidence: 99%

“…Polypharmacy affects 46% and 74.9% of older patients in Saudi Arabia and Jordan, respectively [15,16]. Furthermore, nonadherence to medications is believed to range from 1.4% to 88% in Arab countries.…”

Section: Introductionmentioning

confidence: 99%

Validation of the Arabic Version of Medication Regimen Complexity Index Among Older Patients Validation of the “MRCI-Arabic”

Aksoy,

Ozturk,

Okuyan

et al. 2023

Sudan JMS

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The medication regimen complexity index is widely used in clinical practice and many studies, to assess the complexity of medication regimens. The goal of this study is to validate the medication regimen complexity index-Arabic (MRCI-Arabic) version among older patients. Methods: This methodologic study was conducted in older patients (≥ 65 years old) who were native Arabic speakers at a community pharmacy located in Istanbul, Turkey. After the translation and cultural adaptation process finished, medication regimens of 30 patients were evaluated for test-retest reliability three weeks apart by the rater who was a native Arabic speaker. The inter-rater correlation was calculated in study population (n =100). The link between the number of medications and the score of medication regimen complexity was used to assess convergent validity. The difference in the score of pharmaceutical regimen complexity in stratified age groups was used to examine discriminant validity. Results: The inter-rater and test-retest reliability of the MRCI-Arabic total scale and its subsection were extremely high (Spearman’s rho ranged from 0.996 to 1; p <0.001). There was a strong and positive correlation between the total MRCI-Arabic score and the number of medications (r = 0.830; p < 0.001), the number of chronic diseases (r = 0.641; p < 0.001). Conclusion: The Arabic validation of the MRCI is a validated tool that can be used by native Arabic-speaking healthcare professionals to determine the complexity of their patients’ medication regimens.

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Development of medication regimen complexity index: Japanese version and application in elderly patients

Cited by 5 publications

References 22 publications

Analysis of Various Factors Associated With Opioid Dose Escalation in Patients With Cancer Pain

Analysis of Various Factors Associated With Opioid Dose Escalation in Patients With Cancer Pain

Evaluation of changes in prescription among Japanese elderly patients before and after transition to home care

Validation of the Arabic Version of Medication Regimen Complexity Index Among Older Patients Validation of the “MRCI-Arabic”

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