Development of malignant lymphoma in myoepithelial sialadenitis (Sj�gren's syndrome)

Schmid, U; Helbron, Dagmar; Lennert, K.

doi:10.1007/bf00443482

Cited by 202 publications

(107 citation statements)

References 79 publications

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“…In MESA, lymphoid tissue accumulates in the salivary glands in a fashion closely resembling MALT. The association of MESA with Sj6gren's syndrome is well known, and it seems to be a common if not even necessary precursor for MALT lymphoma of the salivary gland [2,5,11]. In our case, though, we were not able to confirm the presence of Sj6g-ren's syndrome, although multiple laboratory tests were performed (antibodies to double-stranded DNA, to Ro/ SSA and to La/SSB were negative).…”

Section: Discussioncontrasting

confidence: 66%

Diagnosis of MALT lymphoma by conjunctival biopsy: a case report

Kurz–Levin

Flury

Bernauer

1997

Graefe's Arch Clin Exp Ophthalmol

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Section: Discussioncontrasting

confidence: 66%

Diagnosis of MALT lymphoma by conjunctival biopsy: a case report

Kurz–Levin

Flury

Bernauer

1997

Graefe's Arch Clin Exp Ophthalmol

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“…As many as 20% of salivary lymphoepithelial lesions contain lymphoma at first biopsy (Gleeson et al, 1986). Lymphomas develop as an expansion of monoclonal Bcells which form large pale "proliferation areas" around epithelial islands or ducts (Schmid et al, 1982). These cells frequently have irregular cleaved nuclei and resemble centrocytes (Hyjek et al, 1988), although they may also appear monocytoid or show plasmocytic differentiation (Shin et al, 1991;Isaacson, 1993).…”

Section: Salivary Lympho-epithelial Lesions and Lymphoma Developmentmentioning

confidence: 99%

“…Using immunohistochemistry to identify k or X light-chain restriction, investigators have detected populations of monoclonal B-cells in up to 60% of cases (Schmid et al, 1982;Hyjek et al, 1988), of which about one-third may progress to clinically detectable disseminated lymphoma (Hyjek et al, 1988). Recent molecular biological studies have confirmed these findings and have shown a high incidence of monoclonal heavy-chain gene re-arrangements, both by Southern blot analysis (Fishleder et al, 1987;Freimark et al, 1989) and by PCR techniques (De Vita et al, 1994;Diss et al, 1995).…”

Section: Salivary Lympho-epithelial Lesions and Lymphoma Developmentmentioning

confidence: 99%

Current Concepts of Autoimmune Exocrinopathy: Immunologic Mechanisms in the Salivary Pathology of Sjögren's Syndrome

Fox

Speight

1996

Critical Reviews in Oral Biology & Medicine

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Sjogren's syndrome is a systemic autoimmune disorder characterized by symptoms of oral and ocular dryness and a chronic, progressive loss of salivary and lacrimal function. The exocrine involvement is the result of a focal, peri-ductal mononuclear cell infiltrate and the subsequent loss of secretory epithelial cells. The mechanisms of this autoimmune exocrinopathy are not understood fully. Many recent investigations have described alterations in a number of immune mediators within the salivary glands. These studies provide new insights into the immune regulation of normal salivary gland functions and the mechanisms of gland damage in Sjogren's syndrome.

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“…Several reports have demonstrated the occurrence of myoepithelial islands in biopsy specimens of the parotid glands that also contained lymphoma; therefore, the occurrence of myoepithelial islands can no longer be taken as definitive evidence for the "benign" condition of a biopsy sample (57)(58)(59). Persistent major salivary gland swelling also may result from adenoma or carcinomas (Table 2).…”

Section: Differential Diagnosis Of Enlarged Major Salivary Glandsmentioning

confidence: 99%

Sjögren's syndrome. Proposed criteria for classification

Fox¹,

Robinson²,

Curd³

et al. 1986

Arthritis & Rheumatism

617

230

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The term “Sjögren's syndrome” (SS) is frequently used to describe the occurrence of keratocon‐junctivis sicca and xerostomia in association with an autoimmune disorder. However, well‐defined criteria for the classification of SS have not been established, and this diagnosis is being applied to a wide spectrum of conditions, ranging from clear “autoimmune” disease in some patients, to sicca complaints without evidence of a systemic immune process in elderly patients. Here, we review the clinical and laboratory features of patients referred for evaluation of sicca symptoms. In particular, we emphasize the need for care in choosing the site for minor salivary gland biopsy, and we describe the histologic features that aid in the evaluation of these biopsy specimens. In an attempt to identify a population of patients whose conditions might have a common etiopathogenesis and, thus, a common treatment program, we propose the following criteria for a diagnosis of SS: 1) objective evidence of keratoconjunctivis sicca, as documented by rose bengal or fluorescein dye staining; 2) objective evidence of diminished salivary gland flow; 3) minor salivary gland biopsy, obtained through normal mucosa, with the specimen containing at least 4 evaluable salivary gland lobules, and having an average of at least 2 foci/4 mm2; 4) evidence of a systemic autoimmune process, as manifested by the presence of autoantibodies, such as rheumatoid factor and/or anti‐nuclear antibody. The diagnosis of “definite SS” would be made when all 4 criteria are met; the diagnosis of “possible SS” would be made when 3 criteria are present. Specific exclusions for this diagnosis are preexisting lymphoma, graft‐versus‐host disease, sarcoidosis, and acquired immunodeficiency disease. These proposed criteria are more restrictive than are those currently used for diagnosing SS. Future multicenter trials will be required to determine whether these criteria are generally useful. Finally, we emphasize the rheumatologist's role in selecting safe, inexpensive methods of objectively monitoring sicca complaints (i.e., kerato‐conjunctivitis sicca and parotid salivary flow) and in evaluating the results of minor salivary gland biopsy.

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Development of malignant lymphoma in myoepithelial sialadenitis (Sj�gren's syndrome)

Cited by 202 publications

References 79 publications

Diagnosis of MALT lymphoma by conjunctival biopsy: a case report

Diagnosis of MALT lymphoma by conjunctival biopsy: a case report

Current Concepts of Autoimmune Exocrinopathy: Immunologic Mechanisms in the Salivary Pathology of Sjögren's Syndrome

Sjögren's syndrome. Proposed criteria for classification

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