Development of low-cost, weight-adjustable clofazimine mini-tablets for treatment of tuberculosis in pediatrics

Warnken, Zachary; Trementozzi, Andrea; Martins, Patricia P.; Parekh, Jagruti; Koleng, John J.; Smyth, Hugh D.C.; Brunaugh, Ashlee

doi:10.1016/j.ejps.2023.106470

Cited by 3 publications

(1 citation statement)

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“…The first-line anti-tubercular drugs utilized during this study included INH, PZY, and RIF [19]. However, resistance against first-line agents is drastically increasing, and there is a need for new anti-tubercular drug combinations as well as new drug entities to assist in the fight against TB [37,38].…”

Section: Methods For Drug and Excipient Selectionmentioning

confidence: 99%

The Development of Dermal Self-Double-Emulsifying Drug Delivery Systems: Preformulation Studies as the Keys to Success

van Staden,

Haynes,

Viljoen

2023

Pharmaceuticals

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Self-emulsifying drug delivery systems (SEDDSs) are lipid-based systems that are superior to other lipid-based oral drug delivery systems in terms of providing drug protection against the gastrointestinal (GI) environment, inhibition of drug efflux as mediated by P-glycoprotein, enhanced lymphatic drug uptake, improved control over plasma concentration profiles of drugs, enhanced stability, and drug loading efficiency. Interest in dermal spontaneous emulsions has increased, given that systems have been reported to deliver drugs across mucus membranes, as well as the outermost layer of the skin into the underlying layers. The background and development of a double spontaneous emulsion incorporating four anti-tubercular drugs, clofazimine (CFZ), isoniazid (INH), pyrazinamide (PZY), and rifampicin (RIF), are described here. Our methods involved examination of oil miscibility, the construction of pseudoternary phase diagrams, the determination of self-emulsification performance and the emulsion stability index of primary emulsions (PEs), solubility, and isothermal micro calorimetry compatibility and examination of emulsions via microscopy. Overall, the potential of self-double-emulsifying drug delivery systems (SDEDDSs) as a dermal drug delivery vehicle is now demonstrated. The key to success here is the conduct of preformulation studies to enable the development of dermal SDEDDSs. To our knowledge, this work represents the first successful example of the production of SDEDDSs capable of incorporating four individual drugs.

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Section: Methods For Drug and Excipient Selectionmentioning

confidence: 99%